Clinical trials: Apnoea
Obstructive Sleep Apnea
Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
Obstructive Sleep Apnea Syndrome affect up 12% in adult population. It is associated with an increase rate of hypertension, metabolic syndrome, depression and adverse cardiovascular events.
- Trial name
- DISERT (NCT03892122)
- Testing
- Propofol Fresenius, Dexmedetomidine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Ospedale Monsignor R. Dimiccoli, Barletta
Sleep Apnea, Opioid Use
Sleep Disordered Breathing With Opioid Use
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications.
- Conditions
- Sleep Apnea, Opioid Use, Sleep Disordered Breathing
- Trial name
- SDB (NCT05589753)
- Testing
- Hyperoxia, Acetazolamide
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Otolaryngological Disease, Obstructive Sleep Apnea
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils
The purpose of this study is to compare the effectiveness of a novel personalized surgical approach to the standard AT in children with small tonsils (ST).
- Trial name
- TOPS-ST (NCT06258837)
- Testing
- DISE-Directed Surgery, Adenotonsillectomy
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Oregon Health and Science University
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study
The purpose of study JZP110-405 is to determine whether solriamfetol is effective at improving cognitive function in participants with excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA) plus impaired…
- Conditions
- Excessive Daytime Sleepiness, Obstructive Sleep Apnea, Impaired Cognitive Function
- Trial name
- SHARP (NCT04789174)
- Testing
- Solriamfetol
- Where
- 28 sites in United States, Canada and 4 more
- Volunteers
- 59 people
- Sponsor
- Axsome Therapeutics, Inc.
Obstructive Sleep Apnea Syndrome
Cost-utility Study of Continuous Positive Airway Pressure Treatment in Obstructive Sleep Apnea Syndrome Patients
The purpose of this study is to estimate the cost-utility of continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea (OSA) patients in Sao Paulo city, Brazil, after 3 years of treatment and to estimate the…
- Trial name
- NCT01590420
- Testing
- CPAP S8- Scape / Resmed
- Where
- Brazil
- Volunteers
- 1,000 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Syndrome of Obstructive Sleep Apnea and Hypopneas
Mandibular Advancement Devices Tali® in Patients With Syndrome of Obstructive Sleep Apnea and Hypopneas
The main objective is to evaluate middle term compliance (≥ 2 years) of the Mandibular Advancement Devices Tali® in patients with Syndrome of Obstructive Sleep Apnea and Hypopneas.
- Trial name
- NCT02878629
- Testing
- Mandibular Advancement Devices
- Where
- France
- Volunteers
- 254 people
- Sponsor
- ONIRIS
Insomnia, Obstructive Sleep Apnea
The Impact of CBT-i on CPAP Therapy Use and Drop Outs in OSAS Patients With Insomnia.
Patients follow the fully standard sleep test according to the normal procedure. This means that they undergo a polysomnography and fill in a questionnaire.
- Conditions
- Insomnia, Obstructive Sleep Apnea, Cognitive Behavioral Therapy, Continuous Positive Airway Pressure
- Trial name
- NCT04306835
- Testing
- Cognitive behavioural therapy for insomnia
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitair Ziekenhuis Brussel
Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline
Respiratory Progression in Adults With Duchenne Muscular Dystrophy.
This is a multicenter, longitudinal observational study aimed at characterizing the natural history of respiratory progression in adults with genetically confirmed Duchenne muscular dystrophy (DMD).
- Conditions
- Duchenne Muscular Dystrophy (DMD), Respiratory Function Decline, Restrictive Lung Disease, Respiratory Failure
- Trial name
- GUP24005 (NCT07879989)
- Where
- 13 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Giannina Gaslini
Peripheral Artery Disease
Prevalence of Obstructive Sleep Apnea in Patients With Peripheral Arterial Occlusive Disease
Obstructive sleep apnea syndrome (OSAS) is characterized by partial (hypopnea) or complete (apnea) obstruction of the upper airways, leading to intermittent hypoxemia and sleep fragmentation.
- Trial name
- OSAPAD (NCT07283289)
- Where
- France
- Volunteers
- 295 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Chronic Pain, Obstructive Sleep Apnea
Clinical Outcomes of Continuous Positive Airway Pressure Treatment in People With Obstructive Sleep Apnea and Chronic Pain
The bidirectional link between sleep and pain is a widely accepted concept. While there has been much focus on this in recent years, studies investigating obstructive sleep apnoea (OSA) and chronic pain are still not very common…
- Trial name
- NCT06834724
- Testing
- Standard OSA care
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Vrije Universiteit Brussel
Chronic Kidney Insufficiency, Sleep Apnea
Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease (CKD)
Objectives: Evaluate the effect of CPAP to reduce the progression of chronic kidney disease or CKD (the decline of glomerular filtration rate is ≥ 30%) in patients with early-stage renal disease and sleep apnea syndrome (OSAS).
- Trial name
- Renas (NCT03319888)
- Testing
- CPAP, conservative treatment
- Where
- Spain
- Volunteers
- 700 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related
Bruxism Induced by Obstructive Sleep Apnoea.
The relationship between obstructive sleep apnea (OSA), sleep bruxism, and temporomandibular disorders is becoming clearer, but data on how upper airway volume affects bruxism due to OSA is limited.
- Conditions
- Sleep Apnea Syndrome, Obstructive, Bruxism, Sleep-Related, Upper Respiratory Tract Illness
- Trial name
- OSA Bruxism (NCT07511946)
- Testing
- Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT) and Polysomnography, Upper airway volume assessment using Cone-Beam Computed Tomography (CBCT)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Chronic Respiratory Failure
Database of Patients Treated With Respiratory Support
An observatory of patients registered in 22 local homecare associations in France, for respiratory diseases, with annual data update.
- Trial name
- observatory (NCT01181869)
- Testing
- oxygen
- Where
- France
- Volunteers
- 120,000 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Snoring, Obstructive Sleep Apnea
Intraoral Tongue Stimulation for Treatment of Primary Snoring
Intraoral Neuromuscular Training for Treatment of Snoring Objective Studies show that improving pharyngeal muscle tone can ameliorate obstructive sleep apnoea (OSA) and snoring.
- Trial name
- NCT03829956
- Testing
- Intraoral tongue stimulator (Snoozeal)
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Signifier Medical Technologies
Obstructive Sleep Apnea
Autonomic Function in Obstructive Sleep Apnea
The purpose of this study is to determine if obstructive sleep apnea (OSA) causes autonomic dysfunction independent of its effects on hyperglycemia.
- Trial name
- NCT00681161
- Testing
- continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University
Lung Diseases, Sleep Apnea Syndromes
Epidemiology of Sleep Apnea Syndrome
To define the prevalence of Sleep Apnea Syndrome (SAS) in a community-based sample of Hispanic adults.
- Trial name
- NCT00005286
- Sponsor
- University of New Mexico
Psoriasis, Sleep Apnea, Obstructive
Efficacy and Safety of Adalimumab in Patients With Psoriasis and Obstructive Sleep Apnea
This study will evaluate the effect and safety of adalimumab in approximately 20 subjects with mild to moderate psoriasis and sleep apnea and will be conducted in one treatment center located in Montreal.
- Trial name
- NCT01181570
- Testing
- Adalimumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Innovaderm Research Inc.
Sleep Apnea, Obstructive
Predicting Outcomes in Hypoglossal Nerve Stimulation Therapy With Stimulated Upper Airway Mechanics
Obstructive sleep apnea (OSA) is a highly prevalent disease resulting from dynamic upper airway collapse during sleep. Continuous positive airway pressure (CPAP) is highly efficacious but high rates of non-adherence to CPAP…
- Trial name
- NCT05429983
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Ondine Syndrome
Assessment of Desogestrel in Ondine Syndrome
The congenital central hypoventilation syndrome (CCHS), also known as the Ondine syndrome, is a very rare genetic disorder. In contrast with healthy people, patients do not increase breathing in response to an excess of carbon…
- Trial name
- RESPIRONDINE (NCT01243697)
- Testing
- desogestrel
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive
Effect of Positive Airway Pressure Therapy on Hospitalization and Mortality in SDB Patients With Comorbid Chronic Obstructive Pulmonary Disease (COPD) or/and Heart Failure (HF)
The aim of the study is to test the hypothesis that treatment of sleep disordered breathing (SDB) in patients with comorbid chronic obstructive pulmonary disease (COPD) and/or heart failure (HF) with positive airway pressure…
- Conditions
- Sleep-Disordered Breathing, Pulmonary Disease, Chronic Obstructive, Heart Failure
- Trial name
- NCT02923505
- Testing
- polygraphy or polysomnography
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 383 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
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