Clinical trials: Apnoea
Sleep Apnea Syndromes, Sleep Initiation and Maintenance Disorders
Understanding the Sleep Apnea/Insomnia Interaction
Nearly half of all patients with obstructive sleep apnea have insomnia symptoms, and in some, but not all cases, these insomnia symptoms are caused by the obstructive sleep apnea.
- Trial name
- NCT01824472
- Testing
- CPAP, CBT, CC
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea
Validation of an Integrated Digital Solution (SUNrise®) Versus Polysomnography for Obstructive Sleep Apnea Diagnosis
Validation of an integrated digital solution (SUNrise®) of mandibular movement automatic analysis by artificial intelligence versus polysomnography for obstructive sleep apnea diagnosis: a prospective, randomized, parallel-arm…
- Trial name
- SUNSAS (NCT05057975)
- Testing
- Sunrise, polysomnography
- Where
- 19 sites in France
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- Sunrise
Obstructive Sleep Apnea
RPMO2 Oximeter Accuracy During Sleep 1 Trial
The goal of this observational study is to validate the accuracy of the RPMO2 OSA Device's oxygen desaturation index in individuals with obstructive sleep apnea versus the gold standard, in-lab polysomnography.
- Trial name
- ROADS-1 (NCT07397780)
- Testing
- RPMO2 OSA Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ProSomnus Sleep Technologies
Obstructive Sleep Apnea
Transcutaneous Electrical Stimulation in Obstructive Sleep Apnea
The aim of this study is to assess the efficacy of transcutaneous electrical stimulation of the upper airway muscles in patients with obstructive sleep apnea.
- Trial name
- NCT04932486
- Testing
- Transcutaneous electrical stimulation
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Sunrise
Sleep Apnoea
Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients
The purpose of this study is to report the incidence of ventricular arrhythmias correlated to the SAS and to focus on the interest of diagnosing Sleep-disorders breathing in ICD patients.
- Trial name
- NCT00708786
- Testing
- ICD, CRT-D
- Where
- 31 sites in France, Germany and 2 more
- Volunteers
- 755 people
- Sponsor
- LivaNova
Altitude Hypoxia
Effect of Acetazolamide on Sleep Disordered Breathing in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on sleep disordered breathing in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536507
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Sleep Apnea
Artificial Neural Network Directed Therapy of Severe Obstructive Sleep Apnea
The investigators have developed a simple, accurate, and a point-of-care, computer-based clinical decision support system (CDSS) not only to detect the presence of sleep apnea but also to predict its severity.
- Trial name
- NCT01286636
- Testing
- computer model, Polysomnogram
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Drug Induce Sleep Endoscopy, Hypnosis
Feasibility Study of Sleep Endoscopy Under Hypnosis in a Sleep Center
It is proposed to induce in a obstructive sleep apnea syndrome patient, a hypnotic trance leading to intense muscle relaxation, capable of reproducing in the upper airways (VAS) the muscle relaxation observed in sleep, at the…
- Conditions
- Drug Induce Sleep Endoscopy, Hypnosis, Obstructive Sleep Apnea Syndrome
- Trial name
- DISE (NCT05091164)
- Testing
- Drug induce sleep endoscopy of upper aerodigestive tract under hypnosis
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Elsan
Sleep Apnea Syndromes
Race And CPAP Effectiveness
Obstructive sleep apnea (OSA) is a major public health problem in the U.S. and more than 35% of Veterans are at high risk for OSA. OSA is associated with progression of hypertension, an important health problem in Veterans.
- Trial name
- RACE (NCT01960465)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
OSA
Long Follow up on Patients With Obstructive Sleep Apnea That Undergo Diagnosis and Surgical Treatment
Long follow up on patients with obstructive sleep apnea that undergo diagnosis and surgical treatment
- Trial name
- OSA (NCT02976207)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Obstructive Sleep Apnea
The Effects of Provent® on Obstructive Sleep Apnea During Continuous Positive Airway Pressure Therapy Withdrawal
Randomised, placebo-controlled trial of continuous positive airway pressure therapy (CPAP) versus Provent® and Placebo-Provent® to define the effects of Provent® on the severity of obstructive sleep apnea, daytime symptoms as…
- Trial name
- NCT01332175
- Testing
- Provent®, CPAP
- Where
- 3 sites in Switzerland, United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Zurich
Obstructive Sleep Apnea (OSAS)
Obstructive Sleep Apnea and Body Awareness
Obstructive Sleep Apnea Syndrome (OSAS) is a chronic disease characterized by intermittent hypoxia and sleep fragmentation resulting from recurrent upper airway obstructions.
- Trial name
- NCT07743892
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Karabuk University
OSA
OSA Recurrence in CPAP Withdrawal
Continuous positive airway pressure (CPAP) therapy is the most effective Treatment for obstructive sleep apnoea (OSA ). However, adherence to CPAP is often limited.
- Trial name
- NCT03472612
- Testing
- CPAP withdrawal
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Apnoea, Prematurity
Automated Apnoea Detection in Preterms on Non-invasive Ventilation
The aim of this study is to monitor the frequency of apnoeas (pauses in breathing) on various methods of non-invasive respiratory support that are detected by an automated machine-learning (ML) model based on diaphragmatic…
- Trial name
- NCT07794007
- Testing
- Diaphragmatic electromyography
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Apnea, Obstructive Sleep, Obesity
Association of Body Fluid Distribution With Obstructive Sleep Apnea in Pregnant Women With Body Mass Index ≥ 40 kg/m2
Obstructive Sleep apnea (OSA) is a common and underdiagnosed condition in obese pregnant women with serious and life-threatening complications to the mother and baby.
- Trial name
- NCT04187612
- Testing
- Bioelectrical Impedance Analysis (BIA)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Obstructive Sleep Apnea
Variable Negative External Pressure (vNEP) - An Alternative to Continuous Positive Airway Pressure (CPAP) for the Treatment of Obstructive Sleep Apnea (OSA): A Pilot Study
Non-compliance rates estimated at 50% pose a major issue for CPAP therapy, the primary treatment for OSA. Negative external pressure, applied over the anterior neck under the mandible, has shown encouraging results as an…
- Trial name
- NCT04718142
- Testing
- vNEP
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Somne, LLC
Obesity, Bariatric Surgery Candidate
Impact of Bariatric Surgery in Obese Patients With and Without Obstructive Sleep Apnea Syndrome
It has been shown to date that obesity is associated with increased mortality and that weight loss significantly improves cardiovascular risk factors.
- Conditions
- Obesity, Bariatric Surgery Candidate, Apnea, Obstructive
- Trial name
- COLOSS (NCT04179188)
- Testing
- Bariatric surgery
- Where
- France
- Volunteers
- 400 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Central Sleep Apnea
remedē System Therapy Study
The purpose of this non-randomized post market study is to collect clinical data on the safety and effectiveness of the remedē System in a real-world setting.
- Trial name
- rēST (NCT03884660)
- Testing
- remede System
- Where
- 32 sites in United States, Netherlands
- Volunteers
- 225 people
- Sponsor
- Respicardia, Inc.
Obstructive Sleep Apnoea Hypopnoea Syndrome, Biomarkers of Fibrin Clot Structure
New Markers to Measure Clotting in Patients With the Obstructive Sleep Apnoea Hypopnoea Syndrome
Obstructive Sleep Apnoea Hypopnoea Syndrome(OSAHS)affects at least 4% of males and 2% of females. OSAHS is the combination of excessive daytime sleepiness, snoring and apnoeas (stopping breathing at night).
- Conditions
- Obstructive Sleep Apnoea Hypopnoea Syndrome, Biomarkers of Fibrin Clot Structure, Biomarkers of Vascular Endothelial Injury
- Trial name
- NCT01525160
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Hywel Dda Health Board
Sleep Apnea, Obstructive, Patient Compliance
Continuous Positive Airway Pressure (CPAP) Compliance in Obstructive Sleep Apnea
This study aims to determine the average compliance of a patient under CPAP therapy for obstructive sleep apnea as well as the various factors that influence it.
- Trial name
- CPAPcompl (NCT02301923)
- Where
- Lebanon
- Volunteers
- 450 people
- Sponsor
- Saint-Joseph University
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