Clinical trials: Apoplexy; Brain
Stroke, Sleep Wake Disorders
The SLEEPR Study: SLEep Effects on Post-stroke Rehabilitation
Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with stroke.
- Conditions
- Stroke, Sleep Wake Disorders, Rehabilitation, Recovery of Function
- Trial name
- SLEEPR (NCT05012605)
- Testing
- Observation
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- State University of New York - Upstate Medical University
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Post-Stroke Hemiplegia
Wearable Robotic and Virtual Reality on Hand in Stroke
Stroke is a common neurological disorder resulting from acute focal damage to the central nervous system due to vascular events such as cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage.
- Trial name
- NCT07287059
- Testing
- Soft Robotic Glove (SRG), Leap Motion Controller (LMC), Neurodevelopmental Therapy (NDT)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Medipol University
Swallowing Disorders, Stroke
The Effectiveness of Oral Health in Improving Dysphagia of Patients After Stroke of Swallowing Function and Oral Health Quality of Life
The prevalence of chewing dysphagia in the domestic rehabilitation department ward was about 53.61%.Nasal tube retention of about 31%, due to nasogastric tube feeding, often overlooked oral hygiene, easy to cause respiratory…
- Trial name
- NCT03219346
- Testing
- oral care program
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Right-to-left Shunt, Migraine
Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population
The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.
- Conditions
- Right-to-left Shunt, Migraine, Cerebral Infarction
- Trial name
- NCT02425696
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Yingqi Xing
Acute Ischemic Stroke
Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT07389460
- Testing
- Intravenous rhPro-UK, Endovascular thrombectomy
- Where
- 10 sites in China
- Volunteers
- 820 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Spinal Cord Injuries, Multiple Sclerosis
Functional and Physiological Responses to Lokomat Therapy (Pilot Study)
Individuals with neurological deficiencies such as those who have spinal cord injury, stroke, traumatic brain injury, Parkinson's disease, and multiple sclerosis often lose their ability to ambulate over ground.
- Conditions
- Spinal Cord Injuries, Multiple Sclerosis, Stroke
- Trial name
- NCT00883142
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- US Department of Veterans Affairs
Stroke
Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke
This is a single-center, prospective, observational cohort study that plans to consecutively enroll 400 patients with acute ischemic stroke from July 2026 to July 2029.
- Trial name
- NCT07741669
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Upper Limb Injury
A STudy of Upper Arm Rehabilitation in Stroke Survivors- ASTAR
This feasibility study will explore the clinical effectiveness of additional upper limb therapy compared to standard care delivered to Stroke Survivors at Sussex Rehabilitation Centre (SRC).
- Conditions
- Stroke, Upper Limb Injury, Rehabilitation
- Trial name
- ASTAR (NCT05300659)
- Testing
- Action for Rehabilitation for Neurological Injury (ARNI)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Dr Khalid Ali
Stroke
Decentralized Imaging by REmote Computer Tomography for Cerebral Infarct Thrombolysis
The DIRECT-CT trial is designed to test the hypothesis that remote controlled CT scanning combined with real time audio-and video conference (AVC) guided assessment from an experienced hospital stroke team (tele-stroke) at…
- Trial name
- DIRECT-CT (NCT07530588)
- Testing
- Decentralized diagnostics and treatment
- Where
- 2 sites in Norway
- Volunteers
- 52 people
- Sponsor
- University Hospital of North Norway
Hemiplegia
Quantification of Arm Non-Use After a Stroke
Reproducibility assessment of a quantitative measure of the amount of trunk compensation by kinematic analysis in a grasping task in stroke patients.This "maladaptive trunk compensation" is suspected to be underlined by "arm…
- Trial name
- NCT02326688
- Testing
- Kinematic analysis of trunk compensation
- Where
- France
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Aphasia, Stroke
Stepped Care for Aphasia
This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not…
- Trial name
- NCT05851573
- Testing
- Psychosocial intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Aphasia
Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia
This study tests whether weak electrical stimulation of the brain is effective in improving language or reading difficulties occurring after a brain injury or stroke.
- Trial name
- NCT01709383
- Testing
- Transcranial Direct Current Stimulation
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Georgetown University
Ischemic Stroke
Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke
Rationale: Over 20.000 people suffer an ischemic stroke in the Netherlands each year. Large artery occlusions are easy to identify and can be treated with endovascular clot removal.
- Trial name
- ENCLOSE (NCT04019483)
- Where
- 3 sites in Netherlands
- Volunteers
- 439 people
- Sponsor
- UMC Utrecht
Heart Failure, Cardiovascular Diseases
Nene Remote Monitoring Proof of Concept
This feasibility study is being conducted to investigate the practicalities and potential benefits of equipping patients with wearable monitoring devices.
- Conditions
- Heart Failure, Cardiovascular Diseases, Respiratory Disease, Stroke
- Trial name
- NCT04598659
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Doccla UK
Stroke, Ischemic Attack, Transient
Carotid Occlusion Surgery Study
The purpose of this study is to determine if extracranial-intracranial bypass surgery when added to best medical therapy can reduce the subsequent risk of ipsilateral stroke in high-risk patients with recently symptomatic carotid…
- Conditions
- Stroke, Ischemic Attack, Transient, Cerebral Infarction
- Trial name
- COSS (NCT00029146)
- Testing
- extracranial-intracranial bypass surgery, best medical therapy
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of North Carolina, Chapel Hill
Cognitive Neurodegenerative, Stroke
The Links Between Executive and Linguistic Processes and Their Lesional Determinants From a Verbal Fluency Task
Verbal fluency test require to produce as much words as possible in one or two minutes. This test is highly sensitive to main brain diseases and are therefore widely used in clinical routine for diagnostic purpose.
- Conditions
- Cognitive Neurodegenerative, Stroke, Verbal Fluency Disorders
- Trial name
- FluLEx (NCT05875103)
- Testing
- linguistic processes
- Where
- France
- Volunteers
- 302 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Stroke, Upper Extremity Paresis
Graded Repetitive Arm Supplementary Program Versus Task Based Training on Upper Limb Function in Stroke Patients
To determine effects of graded repetitive arm supplementary program versus Task based training on Upper limb function in stroke patients.
- Conditions
- Stroke, Upper Extremity Paresis, Motor Activity
- Trial name
- NCT06397170
- Testing
- Graded repetitive arm supplementary program, Task based training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Post-stroke Aphasia
Neurostimulation for the Treatment of Post-Stroke Aphasia
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
- Trial name
- NCT05194566
- Testing
- tACS
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- QVITI S.A.
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