Clinical trials: Appendectomy
Appendicitis
Appendectomy vs. Symptomatic Treatment in Uncomplicated Acute Appendicitis Among Pediatric Patients
The APPSYPP trial is a randomized national multicenter feasibility superiority pilot study comparing appendectomy with symptomatic treatment in children with imaging-confirmed uncomplicated acute appendicitis.
- Trial name
- APPSYPP (NCT05289713)
- Testing
- appendectomy
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Helsinki University Central Hospital
Appendicitis, Abdominal Abscess
Laparoscopic Management of Periappendicular Abscess
According to retrospective studies the conservative management of periappendicular abscess is associated with decreased complication and re-operation rate compared with open appendectomy.
- Trial name
- NCT01283815
- Testing
- Laparoscopic appendectomy, Conservative management with percutaneous drainage
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Appendicitis Acute
Leave or Laparoscopic Appendectomy With Normal Findings - a Regional Cohort Study
Based on a regional cohort, this study we will try to demonstrate the superiority of routine laparoscopic appendectomy vs. leaving an intraoperative assessed normal appendix in situ in cases of normal findings at diagnostic…
- Trial name
- NCT06000020
- Testing
- Laparoscopic appendectomy
- Where
- 4 sites in Denmark
- Volunteers
- 1,435 people
- Sponsor
- Nordsjaellands Hospital
Laparoscopic Appendectomy, Bipolar Diathermy
Use of Bipolar Diathermy VS Clips in Laparoscopic Appendectomy
Acute Appendicitis is the most frequent acute pathological abdominal illness needing immediate surgery. The laparoscopic appendectomy (LA) has become more popular and is advised as the first course of treatment, particularly for…
- Trial name
- NCT06826651
- Testing
- laparoscopic appendectomy, bipolar diathermy, clips closure
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Appendicitis
Role of Wound Irrigation After Appendectomy
Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection.
- Trial name
- NCT03773224
- Testing
- Irrigation
- Where
- Egypt
- Volunteers
- 179 people
- Sponsor
- Mansoura University
Appendicolith, Appendicitis
Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome
Laparoscopy has revolutionized the approach to a number of surgical problems causing a re-evaluation of several clinical strategies.
- Conditions
- Appendicolith, Appendicitis, Appendicitis With Perforation, Appendicitis Peritonitis
- Trial name
- LAPSUS (NCT03770897)
- Testing
- 3D Laparoscopic Appendectomy, 2D Laparoscopic Appendectomy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Appendicitis (Diagnosis)
Precision Antibiotic Dosing for Appendectomy
This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix.
- Trial name
- PANDA (NCT06860802)
- Testing
- Cefoxitin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Parasitic Disease
Enterobius Vermicularis Infestation of the Appendix
This study identifies the incidence of appendiceal Enterobius vermicularis (E.v) infestation in all the patients undergoing appendectomy and evaluates the relationship between E.v infestation of the appendix and the acute…
- Trial name
- NCT04576273
- Testing
- Pathology examination
- Where
- Saudi Arabia
- Volunteers
- 1,150 people
- Sponsor
- Al-Azhar University
ERAS
"Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy"
laparoscopic appendectomy is most common surgical procedure necessitates evidence-based clinical pathways such as Enhanced Recovery After Surgery (ERAS). The paradigm of surgery has been shifted from open to laparoscopic.
- Trial name
- NCT06088082
- Testing
- Bupivacaine Hydrochloride
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King Saud Medical City
Morbid Obesity, Hernia
Minimally Invasive Surgery (MIS) Database for the Purpose of Research
The Minimally Invasive Surgery Team (MIST) are establishing a separate research database to find out more about patient's undergoing minimally invasive surgery (laparoscopic , open and robot assisted) procedures at UCSD.
- Conditions
- Morbid Obesity, Hernia, Colorectal Cancer, Laparoscopy
- Trial name
- NCT00535990
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Acute Appendicitis
Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis
Endoscopic retrograde appendicitis therapy (ERAT) is a new and minimally invasive method for the diagnosis and treatment of acute appendicitis.After a positive diagnosis of acute appendicitis is established by either colonoscopic…
- Trial name
- NCT02789865
- Testing
- Ertapenem, Levofloxacin and Metronidazole, Endoscopic retrograde appendicitis therapy (ERAT), Appendectomy
- Where
- 3 sites in China
- Volunteers
- 240 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pain, Postoperative
Combined Nerve Blockade and Local Infiltration Anesthesia in Appendectomy - A Blinded Randomized Study
The purpose of this study is to assess whether the use of local anesthetic to numb the nerves that run deeper in the abdominal wall gives better post operative pain control than just infiltrating local anesthetic to the wound…
- Trial name
- NCT00508092
- Testing
- local anesthetic administration
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Royal Berkshire NHS Foundation Trust
Wound Infection, Complication
Abdomen CT and Open Appendicectomy：New Diagnostic and Surgical Procedures
The traditional open appendectomy in the clinical effect is not prefect, and for a long time there is no measurable improvement.
- Conditions
- Wound Infection, Complication, Scar
- Trial name
- ACAOA (NCT02574364)
- Testing
- The application of abdomen CT, traditional incision
- Volunteers
- 730 people
- Sponsor
- Ningbo Municipal No.4 Hospital
Uncomplicated Acute Appendicitis in Children
Early vs Conventional Enteral Nutrition After Uncomplicated Paediatric Open Appendectomy
This clinical trial is conducted to see if after surgery of appendix(open appendectomy) in children giving oral nutrition within 6hours of surgery instead of older method of starting oral nutrition after 24hours of surgery…
- Trial name
- NCT07016919
- Testing
- early enteral nutrition, Conventional enteral nutrition
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Appendicitis, Surgery
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
This study is designed as a randomized controlled trial with patients assigned to neuromuscular reversal with either sugammadex or neostigmine/glycopyrrolate reversal.
- Trial name
- NCT05256901
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Appendix Rupture, Pain
Virtual Reality for Appendectomy Pain
To determine the impact of VR-Biofeedback and VR-Distraction on pain and medication utilization in children and adolescents undergoing surgery for ruptured appendix.
- Conditions
- Appendix Rupture, Pain, Pain, Postoperative
- Trial name
- NCT04357132
- Testing
- VR-Biofeedback, VR-Distraction
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Laparoscopic Surgery, Surgical Wound
Triclosan-antibacterial Sutures Impact on the Incidence of Surgical Site Infection in Laparoscopic Surgeries.
Comparing the incidence of PSI in cases using coated Polyglactin 910 suture with Triclosan and cases using Polyglactin 910 suture without Triclosan in laparoscopic sleeve gastrectomy, laparoscopic appendectomy or laparoscopic…
- Conditions
- Laparoscopic Surgery, Surgical Wound, Surgical Site Infection
- Trial name
- NCT04255927
- Testing
- Coated Vicryl plus, Coated vicryl
- Where
- Egypt
- Volunteers
- 912 people
- Sponsor
- ClinAmygate
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital