Clinical trials: Appendicitis (Diagnosis)
Acute Appendicitis, Abscess
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
Patients who are diagnosed with acute appendicitis consented and then randomized into two arms of the trial. In one arm, patients receive irrigation of the abdomen during surgery with normal saline, or salt water.
- Trial name
- WASHITBEST (NCT02714023)
- Testing
- Normal Saline, Sterile Water
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Perforated Appendicitis
Evaluation the Role of Laparoscopic Management of Perforated Appendicitis
A laparoscopic appendectomy (LA) was first reported by Semm in 1983. Since then, its advantages, such as the aesthetic appearance of the wound, less postoperative pain, and faster recovery which facilitates early discharge, have…
- Trial name
- NCT03267082
- Testing
- Laparoscopic management of perforated appendicitis
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Appendicitis
Abdominal Drainage During Appendicectomy - Resources Down the Drain: A Retrospective Cohort Study
The investigators performed a retrospective review of all patients undergoing appendicectomy from March-November 2018 using the online theatre database and discharge letters.
- Trial name
- NCT04163211
- Testing
- Abdominal drain
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Whittington Hospital NHS Trust
Acute Appendicitis
Appendicectomy Versus Antibiotics in the Treatment of Acute Uncomplicated Appendicitis
Appendicectomy has been the treatment of acute appendicitis for over a hundred years. Appendicectomy, however, includes operative and postoperative risks despite being a "routine" operation.
- Trial name
- APPAC (NCT01022567)
- Testing
- Appendicectomy, Ertapenem
- Where
- 6 sites in Finland
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Acute Appendicitis
Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis
The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers…
- Trial name
- PROADM-APP (NCT07889544)
- Testing
- Serum Pro-Adrenomedullin Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock
Artificial Intelligence-driven Virtual Standardized Pediatric Patients Trial
Background: China's healthcare system for children faces significant challenges, particularly due to the limited pediatric service capacity of primary healthcare institutions.
- Conditions
- Pneumococcal Pneumonia, Rotavirus Enteritis With Hypovolemic Shock, Hand-foot-and-mouth Disease, Acute Appendicitis
- Trial name
- NCT06699433
- Testing
- Virtual standardized patients (VSPs), Case teaching manuals, Case teaching videos
- Where
- 3 sites in China
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Southern Medical University, China
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Acute Appendicitis
The Comparison of Single Incision Laparoscopic Appendectomy and Three Port Laparoscopic Appendectomy
Laparoscopic techniques have allowed surgeons to perform complicated intrabdominal surgery with minimal trauma. In numerous studies, when conventional laparoscopic appendectomy using 3 ports is compared with open appendectomy, it…
- Trial name
- NCT01816568
- Testing
- SILS appendectomy, Three port laparoscopic appendectomy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Telemedicine
The Feasibility Study for Real-time Remote CT Reading for Suspected Acute Appendicitis Using iPhone
1. Purpose The investigators aim to evaluate the feasibility of iPhone based remote control system as a real-time remote CT reading tool for suspected appendicitis under 3G network and the suboptimal illumination. 2.
- Trial name
- Telemedicine (NCT02108717)
- Testing
- Remote CT reading using the iPhone, CT reading using LCD monitor
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Appendicitis (Diagnosis), Acute Appendicitis
Alvarado Score in the Meta Department
The project aims to determine the frequency of use of the Alvarado score among emergency department physicians at facilities in Villavicencio, Colombia.
- Trial name
- NCT07370896
- Where
- Colombia
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Hospital Departamental de Villavicencio
Appendicitis
The Circulating Fibrocyte - a Novel and Accurate Biomarker in Diagnosing Acute Appendicitis in Adults
Accurate diagnostic biomarkers for acute appendicitis (AA) are lacking. Circulating fibrocytes (CFs) are increased in inflammatory states. It is not known whether they are altered in appendicitis.
- Trial name
- NCT03988660
- Testing
- Circulating fibrocytes
- Where
- Ireland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital of Limerick
Appendicitis
Antimicrobial Stewardship in Pediatric Surgery
Acute appendicitis is a common surgical emergency in children. Non-perforated appendicitis patients do not require antibiotics after appendectomy.
- Trial name
- AbxPS (NCT02270996)
- Testing
- Antimicrobial Stewardship Program
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Perforated Appendicitis, Postoperative Infection
Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy.
- Trial name
- NCT03289351
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Appendicitis Acute, Appendicitis
Safety & Feasibility of PERIsign System in Demonstrating Involuntary Muscle Defense as a Sign of Peritonitis in Subjects With Appendicitis
This will be an explorative, proof-of-principle, open, multi-center investigation. The investigation aims to investigate the safety of the PERIsign system and the ability of physicians to differentiate between healthy individuals…
- Conditions
- Appendicitis Acute, Appendicitis, Abdominal Pain, Peritonitis
- Trial name
- PeriSaFe01 (NCT06296953)
- Testing
- PERIsign examination
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- STB INN AB
Pain, Appendicitis
Laparoscopic Transversus Abdominis Plane Block (LTAP) for Appendicectomy Versus Standard Port Site Treatment
This study aims to compare Laparoscopic assisted LTAP (Transversus Abdominis Plane) to standard port-site infiltration in terms of post-operative visual analogue scores (VAS) for pain at 3, 6, 12 and 24 hours following…
- Conditions
- Pain, Appendicitis, Surgery, Analgesia
- Trial name
- TapBlock (NCT05427266)
- Testing
- Tap Block - Bupivacaine
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Acute Appendicitis
Non-operative Treatment of Acute Non-perforated Appendicitis
Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial.
- Trial name
- NCT04030741
- Testing
- Meronem and flagyl, Appendectomy
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Acute Appendicitis
Clinical Diagnosis of Acute Appendicitis with Normal WBCS Count with Role of Inflammatory Markers and Radiology
The aim of this study is to describe the proportion of pa-tients with normal preoperative inflammatorymarkers among patients with histopathologically proven acute appendicitis
- Trial name
- NCT06834958
- Testing
- Appendectomy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Appendicitis
MANAGEMENT OF APPENDICITIS DURING THE COVID-19 PANDEMIC
During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA…
- Trial name
- observational (NCT04615728)
- Testing
- laparoscopic or open appendicectomy
- Where
- United Kingdom
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Acute Appendicitis in Elderly
Clinicopathological Aspects of Acute Appendicitis in Patients Above Age of Thirty at Sulaimani Emergency Hospital
Aims of this study are : Estimate the incidence of A.A. in patients above age of 30 y in 4 age groups . Correlate between different clinical aspects and histopathological results.
- Trial name
- NCT04033198
- Testing
- Appendectomy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani