Clinical trials: Appendicitis Surgery
Acute Appendicitis
Antibiotics vs Surgery in Acute Appendicitis
The aim of this study is to identify clinical, laboratory, and imaging parameters that can predict the most appropriate treatment strategy in patients diagnosed with acute appendicitis.
- Trial name
- NCT07492329
- Testing
- surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, Antibiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sebahattin Celik MD
Appendicitis
Single-incision Laparoscopic (SILS) Versus Conventional Laparoscopic Appendectomy for the Treatment of Acute Appendicitis
Recent advances in laparoscopic instrumentation have made it possible to perform intra-abdominal operations entirely through a small incision that can be hidden within the umbilicus.
- Trial name
- NCT00997516
- Testing
- SILS appendectomy, conventional laparoscopic appendectomy
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of California, San Francisco
Appendicitis
Is Interval Appendectomy Necessary?
Appendicitis is one of the most common surgical problems in children, with 20-35% of patients having perforated by the time they present to a doctor. In these cases, the patient is often treated non-surgically with antibiotics.
- Trial name
- NCT01853683
- Testing
- Conservative Management, Operative Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Children's Hospital of Eastern Ontario
Appendicitis, Cholecystitis
NOVOsyn® for Trocar Incision After Laparoscopic Appendectomy and Cholecystectomy
The aim of this study is to evaluate if the application of a Chlorhexidine coated suture (Novosyn® CHD) will reduce the colonization of bacteria in comparison to an uncoated suture (Novosyn®) used for the closure of trocar wounds…
- Trial name
- NOVOTILAC (NCT04033211)
- Testing
- Novosyn® CHD for fascia and skin closure, Novosyn® for fascia and skin closure
- Where
- 4 sites in Germany, Spain
- Volunteers
- 316 people
- Sponsor
- Aesculap AG
Acute Uncomplicated Appendicitis
Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children
The majority of children with uncomplicated acute appendicitis may be considered for either a non-operative or an operative management.
- Trial name
- NACAC (NCT07587450)
- Testing
- Amoxi Clavulanate, appendicectomy
- Where
- 10 sites in France
- Volunteers
- 724 people
- Sponsor
- University Hospital, Toulouse
Gallstones, Appendicitis
Hybrid Transvaginal-Transabdominal Endoscopic Surgery
The is a pilot study to evaluate the safety and efficacy of hybrid transvaginal-transabdominal procedures. Diagnostic peritoneoscopy (visualizing the inside of the abdomen), appendectomy (removal of the appendix), and…
- Conditions
- Gallstones, Appendicitis, Pelvic Pain
- Trial name
- NCT01039129
- Testing
- Endoscopic Cholecystectomy, Endoscopic Appendectomy, Endoscopic Peritoneoscopy
- Where
- United States
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Surgery
Acute Appendicitis in Foreign Workers of Northern Israel
To Compare the outcome to acute appendicitis in foreign workers to the native patients.
- Trial name
- NCT04895163
- Testing
- Laparoscopic appendectomy
- Where
- Israel
- Volunteers
- 117 people
- Sponsor
- HaEmek Medical Center, Israel
Perforated Appendicitis
Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children
To determine the most cost effective way to treat children with perforated appendicitis we will randomize all children presenting with perforated appendicitis to initial operation, with in 24 hours of admission, or to initial…
- Trial name
- NCT00540189
- Testing
- Initial appendectomy, Interval appendectomy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Appendicitis
A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.
A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound…
- Trial name
- NCT04332809
- Testing
- saline-gentamicin irrigation, saline irrigation
- Where
- Egypt
- Volunteers
- 208 people
- Sponsor
- Mansoura University
Acute Appendicitis, Acute Appendicitis With Rupture
Prioritisation of Acute Appendicitis Using Appendistat Score
Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment.
- Trial name
- APEX (NCT07197489)
- Where
- 2 sites in United Kingdom
- Volunteers
- 592 people
- Sponsor
- University College, London
ERAS, Pediatric Disorder
Studding the Implementation of ERAS Protocols in Pediatric Surgery
this is a retrospective cohort, descriptive study, investigating the role of ERAS protocols, in pediatric surgery and evaluate the feasibility and effectiveness of implementing these protocols
- Conditions
- ERAS, Pediatric Disorder, Appendicitis, Hydrocele
- Trial name
- NCT04870242
- Testing
- Observational study, non-interventional
- Where
- Jordan
- Volunteers
- 178 people
- Sponsor
- University of Jordan
Acute Appendicitis
Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis
Patients undergoing open appendectomy for acute appendicitis were enrolled in a randomized prospective study.
- Trial name
- NCT01002365
- Testing
- Oxygen delivery, Oxygen administration
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
Surgical Site Infection
Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis
Research hypothesis: Does delayed primary wound closure after appendectomy in adults with complicated appendicitis reduce postoperative superficial surgical site infection compare to primary wound closure.
- Trial name
- NCT01659983
- Testing
- Primary wound closure
- Where
- 7 sites in Thailand
- Volunteers
- 600 people
- Sponsor
- Ramathibodi Hospital
Appendicitis, Surgical Site Infection
Transumbilical Laparoscopic Appendectomy
Transumbilical laparoscopic appendectomy (TULA) is increasingly favored in the treatment of appendicitis within the realm of minimally invasive surgical approaches.
- Trial name
- NCT06177418
- Testing
- Transumbilical laparoscopic appendectomy + Glove finger technique, Standard transumbilical laparoscopic appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Necmi Kadıoğlu Hospital
Acute Appendicitis, Acute Appendicitis With Rupture
Modified Enhanced Recovery Program in Emergency Surgery (MERES)
Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis With Peritonitis, Acute Appendicitis Without Peritonitis
- Trial name
- MERES (NCT03754777)
- Testing
- Laparoscopic appendectomy
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Pirogov Russian National Research Medical University
Appendicular Mass, Acute Appendicitis
Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass
This study compares two standard treatment approaches for patients presenting with an appendicular mass, an inflammatory lump that forms when the appendix becomes severely inflamed and walled off by surrounding abdominal tissues.
- Conditions
- Appendicular Mass, Acute Appendicitis, Appendiceal Phlegmon, Appendicitis With Periappendicular Abscess
- Trial name
- NCT07837531
- Testing
- Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pregnancy Complications, Acute Appendicitis
Fetal Outcomes Among Pregnant Emergency General Surgery Patients
Approximately 1 in 500 pregnant women require non-obstetric surgery. Surgical care for the pregnant woman raises concern for complications adversely affecting pregnancy outcomes.
- Conditions
- Pregnancy Complications, Acute Appendicitis, Acute Cholecystitis, Biliary Pancreatitis
- Trial name
- NCT05085353
- Testing
- non-obstetric acute general surgical disease
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Methodist Health System
Abdominal Adhesions
Clinical Study of the Effectiveness, Tolerability and Safety of the Drug "Anti-spike, Gel, 100 g in Bottles in Package No. 1" Produced by the Republican Unitary Enterprise "Unitekhprom BSU", With a Single Intraperitoneal Use After Surgery in Adult Patients With Acute Phlegmonous Appendicitis
The purpose of the clinical trials is the evaluation of the effectiveness and safety of a single intraperitoneal use of the drug "Antispike, gel, 100 g in a bottle" produced by Unitary Enterprise Unitehprom BSU, Belarus in…
- Trial name
- OLTOSPAN-02 (NCT06365632)
- Testing
- Antispike gel, 100 g in a flask, produced by UNITEHPROM BSU, Republic of Belarus, antegrade appendectomy
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- Research Institute for Physical Chemical Problems of the Belarusian State University
Acute Appendicitis, Appendectomy
RICA (ERAS) Pathway Adherence and Early Discharge Feasibility After Urgent Uncomplicated Appendectomy (APENERAS)
This multicenter, prospective observational study (APENERAS) evaluates adherence to the RICA (ERAS Zaragoza 2022) perioperative care pathway in adults undergoing urgent laparoscopic appendectomy for uncomplicated acute…
- Conditions
- Acute Appendicitis, Appendectomy, Ambulatory Surgery
- Trial name
- APENERAS (NCT07401407)
- Where
- 4 sites in Spain
- Volunteers
- 193 people
- Sponsor
- Hospital Galdakao-Usansolo