Clinical trials: Apraxia of Speech
Childhood Apraxia of Speech
A Randomized Control Trial of Motor-based Intervention for CAS
Childhood apraxia of speech (CAS) is a complex, multivariate speech motor disorder characterized by difficulty planning and programming movements of the speech articulators (ASHA, 2007; Ayres, 1985; Campbell et al., 2007; Davis…
- Trial name
- NCT04642053
- Testing
- Dynamic Temporal and Tactile Cuing
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- New York University
Aphasia, Apraxia of Speech
Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia
Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works.
- Trial name
- NCT05248295
- Testing
- Unison speech (vs. solo), Metrical timing (vs. conversational)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Aphasia, Apraxia of Speech
Changes in Neuroplasticity Following Intensive Rehabilitation of Aphasia and/or Apraxia of Speech
The present study aims to investigate the short- and long-term effects of two weeks of intensive speech-language pathology intervention with additional physiotherapy, on aphasia and apraxia of speech (AOS) and their neural…
- Conditions
- Aphasia, Apraxia of Speech, Dysarthria
- Trial name
- NCT04604444
- Testing
- Multimodal Intensive Rehabilitation of Aphasia and Apraxia of Speech
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Apraxia of Speech
Searching of Apraxia of Speech in Children With Specific Language Impairment
Searching of Apraxia of Speech in Children with Specific Language Impairment
- Trial name
- NCT05584033
- Testing
- Mansora Arabic test battery for childhood apraxia of speech
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Specific Developmental Disorders of Speech and Language, Specific Learning Disorder
Ambulatory Screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD).
To evaluate, in primary care, the sensitivity of Heterophory-Vertical-Labile (HV-Labile) in ambulatory screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD).
- Conditions
- Specific Developmental Disorders of Speech and Language, Specific Learning Disorder, Dyslexia, Developmental, Developmental Coordination Disorder
- Trial name
- TDys (NCT04122820)
- Testing
- Diagnostic of specific learning disabilities or of Developmental Coordination Disorder
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- CNGE IRMG Association
PPA, Non-fluent Aphasia
Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
The study is designed to determine the relationship between structural and functional changes in the brain on imaging and progression of speech and language, neurological and neuropsychological features in patients with…
- Conditions
- PPA, Non-fluent Aphasia, Apraxia of Speech, Primary Progressive Non-fluent Aphasia
- Trial name
- NCT01818661
- Testing
- AV-1451
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Down Syndrome, Cerebral Palsy
Measuring Aided Language Development
The focus of the current study is to systematically investigate the psychometric properties of a range of aided language measures, which are based on the Graphic Symbol Utterance and Sentence Development Framework (Binger \&…
- Conditions
- Down Syndrome, Cerebral Palsy, Apraxia of Speech, Speech Sound Disorder
- Trial name
- MALD (NCT06512168)
- Testing
- AAC Generative Language Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Central Florida
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Aphasia, CVA
Treatment Intensity - Apraxia of Speech
A growing neurorehabilitation literature suggests that intense treatment may be desired to maximize the effects of therapy following neurologic injury.
- Conditions
- Aphasia, CVA, Apraxia of Speech
- Trial name
- NCT02332915
- Testing
- Sound Production Treatment (SPT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Aphasia, Apraxia of Speech
Treatments of Acquired Apraxia of Speech
This study was designed to examine the effects of speech therapy on ability to produce speech sounds in persons with acquired apraxia of speech.
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- Apraxia (NCT01483807)
- Testing
- Sound Production Treatment - Blocked, Sound Production Treatment - Random
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Evaluation of Intensive Language Therapy
Due to Parkinson's Disease (PD) speech and language (SL) deficits may occur. Further, the literature reports that PD patients, who have not undergone deep brain stimulation (DBS), have deficits regarding voice quality (e.g.
- Trial name
- EILT (NCT02935842)
- Testing
- Specific SL-therapy, Rhythmic Balance-Movement Training (rBMT)
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Developmental Verbal Dyspraxia, Autism Spectrum Disorder
Speech Treatment for Minimally Verbal Children With ASD and CAS
Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning.
- Trial name
- TxMVASD+CAS (NCT05066178)
- Testing
- CAS Treatment for Minimally Verbal Children with Autism
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MGH Institute of Health Professions
Childhood Apraxia of Speech, Verbal Apraxia
Role of Omega-DEK in Childhood Apraxia of Speech
This is a 20-week study for children between 3 and 6 years old with confirmed childhood apraxia of speech (CAS). The study includes a 12-week open-label pilot feasibility study of an investigational drug (Omega-DEK) plus…
- Conditions
- Childhood Apraxia of Speech, Verbal Apraxia, Autism
- Trial name
- NCT07216001
- Testing
- Omega-DEK, L-carnitine
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Claudia R. Morris
Stroke, Dysarthria
Deep Brain Stimulation + Therapy for Stroke
The purpose of this study is to evaluate the safety and potential benefits of combining deep brain stimulation (DBS) with targeted speech and swallowing rehabilitation in individuals who have experienced a stroke and have…
- Conditions
- Stroke, Dysarthria, Apraxia, Dysphagia
- Trial name
- NCT07849114
- Testing
- Boston Scientific Vercise Deep Brain Stimulation (DBS) System, Rehabilitation Training Protocol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Pirondini, Elvira, PhD
Childhood Apraxia of Speech, Speech Sound Disorders
Feasibility and Preliminary Effects of a Therapeutic Approach Using Ultrasound Visual Biofeedback in Children With AFI: a Pilot Randomized Clinical Trial.
The aim of this study is to evaluate the feasibility of the Ultrax protocol and estimate preliminary effects on articulatory precision, prosody, and speech motor planning.
- Trial name
- PICOS (NCT07087249)
- Testing
- Ultrasound Visual Feedback, Waitlist
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Aline Mara de Oliveira
Cerebral Palsy, Hydrocephalus
Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain Injuries
This protocol is designed to enable access to intravenous infusions of banked umbilical cord blood (CB), that is thawed and not more than minimally manipulated, for children with various brain disorders.
- Conditions
- Cerebral Palsy, Hydrocephalus, Apraxia of Speech, Hypoxia Ischemia, Cerebral
- Trial name
- NCT03327467
- Testing
- Cord Blood Infusion
- Where
- United States
- Sponsor
- Joanne Kurtzberg, MD
Apraxia, Oral, Apraxia of Speech
Motor Imagery for Treatment Enhancement and Efficacy in Persons With Apraxia of Speech
Treatment of post-stroke apraxia of speech (AOS) requires frequent and ongoing practice with a speech-language pathologist to facilitate lasting behavioral change, which is costly and, therefore, inaccessible to many patients.
- Trial name
- MI-TEE (NCT06467136)
- Testing
- Sound production treatment, Motor Imagery Practice
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Central Florida
Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia
tDCS and Speech Therapy for Motor Speech Disorders Caused by FTLD Syndromes: a Feasibility Study
The investigators will test the feasibility of using transcranial direct current stimulation (tDCS) and speech therapy to treat participants with motor speech disorders caused by Frontotemporal Lobar Degeneration Pathology…
- Conditions
- Nonfluent Aphasia, Progressive, Primary Progressive Nonfluent Aphasia, Primary Progressive Non Fluent Aphasia, Progressive Supranuclear Palsy
- Trial name
- NCT04883229
- Testing
- Halo Neuroscience Neurostimulator
- Sponsor
- University of California, San Francisco
Childhood Apraxia of Speech
The Effects of Caregiver Training on DTTC Treatment Outcomes in CAS
The goal of this clinical trial is to investigate the impact of direct vs. indirect caregiver training on treatment outcomes following a period of Dynamic Temporal and Tactile Cueing (DTTC) intervention combined with home…
- Trial name
- DTTC (NCT05916222)
- Testing
- Dynamic Temporal and Tactile Cueing (DTTC)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- New York University
Aphasia, Apraxia of Speech
MIRAA - Implementation of Intensive Rehabilitation of Aphasia and/or Apraxia of Speech in Swedish Healthcare
Positive outcomes have been shown following intensive treatment of speech and/or language impairment post stroke, but how to design intensive treatment programs to achieve optimal recovery and neuroplasticity changes needs to be…
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- MIRAA (NCT04957225)
- Testing
- MIRAA (Multimodal Intensive Rehabilitation of Aphasia and Apraxia of speech)
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet