Clinical trials: Aqueous Humor
Glaucoma
Comparison of Latanoprost Vs. Timolol
The primary purpose of this study is to show, through a controlled masked clinical study of subjects with ocular hypertension (OHT), that latanoprost increases the low uveoscleral drainage of aqueous humor back to normal levels…
- Trial name
- NCT00579969
- Testing
- Latanoprost, Timolol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Intraocular Pressure, Osteopathic Manipulative Treatment
Effect of Osteopathic Techiniques on Intraocular Pressure
The purpose of this study is to assess the effects osteopathic techniques at the upper cervical vertebrae or at the sphenopalatine ganglia on the intraocular pressure.
- Trial name
- NCT04863209
- Testing
- Upper cervical manipulation, Sphenopalatine ganglion manipulation
- Where
- Brazil
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Dry Eye Disease
Concentration of Ofloxacin Into the Aqueous Humour of Patients With Dry Eye Disease
After topical installation of one drop of 0.3% commercially available ofloxacin (Oxatrex®) four times at intervals of 15min in catarract patients with Dry Eye Disease, aqueous humour samples will be collected intraoperatively…
- Trial name
- NCT05213156
- Testing
- Oxatrex
- Where
- Greece
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University Hospital of Patras
Open Angle Glaucoma
Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution
This is a double-masked, placebo-controlled study which will determine the action of NCX 470 ophthalmic solution, 0.1% on aqueous humor dynamic parameters in healthy volunteers or subjects with OHT.
- Trial name
- Whistler (NCT05938699)
- Testing
- NCX 470
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nicox Ophthalmics, Inc.
Glaucoma
Circadian Rhythms of Aqueous Humor Dynamics in Humans
This study is designed to identify physiological, pharmacological and pathological circadian fluctuations in aqueous humor inflow and outflow, systemic blood pressure and ocular blood flow in humans.
- Trial name
- NCT00572936
- Testing
- Latanoprost, Dorzolamide, Timolol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Uveitic Glaucoma, Anterior Uveitis
Aqueous Humor Dynamics and Hypertensive Uveitis
Uveitis is a disease that affects over 2 million people around the globe, and can ultimately lead to blindness. The proportion of patients with uveitis who become blind has not been reduced over the past 30 years, and this is…
- Trial name
- NCT02765308
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Ocular Infection, Viral
Can COVID-19 Persist in Intraocular Fluid?
Several common viruses thrive and persist in intraocular fluid due to ocular immune privilege. Immune privilege is maintained by lack of lymphatic tissue, a strong blood ocular barrier, and regulation of the systemic immune…
- Trial name
- NCT04945850
- Testing
- routine care intraocular sx
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Glaucoma
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)
Background Glaucoma is a multifactorial, chronic, and progressive eye disease characterized by the irreversible loss of retinal ganglion cells (RGCs).
- Trial name
- NCT07006194
- Testing
- Nicotinamide Tablet
- Where
- 3 sites in Italy
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Polypoidal Choroidal Vasculopathy
Aqueous Humor Level of Cytokines in Polypoidal Choroidal Vasculopathy and Change of Cytokines After Photodynamic Therapy
This is a prospective, comparative control analysis. The investigators want to evaluate the aqueous humor levels of vascular endothelial growth factor in polypoidal choroidal vasculopathy and the effect of photodynamic therapy…
- Trial name
- NCT01360151
- Testing
- ranibizumab(Lucentis), verteporfin(Visudyne)
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Cataract
Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients
By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in…
- Trial name
- DEL-1 and IL-1 (NCT06995131)
- Testing
- Observational Study Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Uşak University
Cystoid Macular Edema, Postoperative, Diabetes Mellitus
Effect of Preoperative Topical Ketorolac on Aqueous Cytokine Levels and Macular Thickness in Cataract Surgery Patients
The purpose of this study is to determine whether there is a relationship between inflammatory cytokines in the aqueous of the eye and thickness of the macula after treatment of topical ketorolac for patients undergoing cataract…
- Trial name
- NCT02646072
- Testing
- Ketorolac tromethamine ophthalmic solution 0.45%
- Where
- Malaysia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Glaucoma, Healthy
Glaucoma Biomarkers
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments.
- Trial name
- NCT01677507
- Testing
- Variation in eye pressure response to timolol and latanoprost treatment
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Subjects
A Controlled Study of the Aqueous Humor Dynamics of AR-13324 Ophthalmic Solution in Healthy Adult Volunteers
To evaluate the effect of netarsudil (AR-13324) ophthalmic solution on aqueous humor dynamics relative to its placebo.
- Trial name
- NCT02406287
- Testing
- Netarsudil (AR-13324) Ophthalmic Solution
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aerie Pharmaceuticals
Primary Glaucoma
Changes of Trace Elements in Aqueous Humor, Blood and Tears and Analysis of Related Factors
Trace elements are one of the indispensable substances in human body and play an important physiological role. Zinc is a trace element second only to iron in organisms, which is widely distributed in various systems and organs…
- Trial name
- NCT04515030
- Where
- China
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery
The purpose of this study is to evaluate the drug concentrations in the conjunctiva and aqueous humor of AzaSite™ compared to Vigamox® in subjects undergoing routine cataract surgery
- Conditions
- Bacterial Infections, Eye Infections, Cataract Extraction
- Trial name
- NCT00575380
- Testing
- AzaSite Eye Drops, Vigamox Eye Drops
- Where
- 13 sites in United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Retinal Vein Occlusion
Aqueous Humor Proteome in Retinal Vein Occlusion With Macular Edema
the goal of this observational study is to the find the molecular mechanisms underlying the prognosis process of Retinal vein occlusion in patients with retinal vein occlusion .
- Trial name
- NCT07106268
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Eye Hospital
Healthy
Aqueous Humor Dynamics and Biometric Parameters in Eyes of Children
The purpose of this study is to determine the effect of age and ethnic background on ocular aqueous humor dynamics and biometric parameters.
- Trial name
- NCT01290588
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Nebraska