Clinical trials: Aqueous-deficient Dry Eye Disease
Dry Eye
Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Dry Eye
The purpose of this study is to explore the efficacy and safety of CsA ophthalmic gel in the treatment of moderate to severe tear deficiency dry eye with different dosage, frequency and concentration, and to preliminarily…
- Trial name
- NCT03676335
- Testing
- CsA eye gel, CsA for eye emulsion, Hypromellose Eye Drops
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Tear, Dry Eye Syndromes
Effect of ADDE on Tear Interferometry
Importance: Lipid layer thickness (LLT) reflects the lipid components of tear film, but is affected by the mucocutaneous components.
- Trial name
- NCT05456061
- Testing
- 3% diquafosol eyedrops, Silicone punctal plug insertion
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Yonsei University
Primary Sjogren Syndrome, Secondary Sjogren Syndrome
Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease
In the present study the investigators aim to determine the efficacy of an immunomodulating topical medication, compared with a topical lubricant, on the treatment of dry eye disease (DED) due to primary or secondary Sjögren's…
- Conditions
- Primary Sjogren Syndrome, Secondary Sjogren Syndrome, Aqueous Deficient Dry Eye Disease, Evaporative Dry Eye Disease
- Trial name
- NCT02004067
- Testing
- Restasis, Refresh Endura
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Dry Eye, Kerato Conjunctivitis Sicca
Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease
The objective of this study is to assess the safety and feasibility of allogeneic adipose tissue-derived mesenchymal stem cells (ASCs) injected into the lacrimal gland in a smaller groups of 7 patients with Aqueous Deficient Dry…
- Conditions
- Dry Eye, Kerato Conjunctivitis Sicca, Aqueous Tear Deficiency
- Trial name
- MESADDE (NCT03878628)
- Testing
- Adipose tissue-derived mesenchymal stem cells
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Dry Eye Syndromes, Sjogren's Syndrome
Effects of Sustained Reading on the Ocular Surface
This research is being done to to see if changes in visual reading function correlate with changes in optical and retinal image quality.
- Trial name
- NCT02031172
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Syndrome
A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome
To determine the effect of Essential Fatty Acids (EFA's) on Meibomian Gland lipids and aqueous tear production in patients with "dry eyes".
- Trial name
- NCT00344721
- Testing
- Omega-3 fatty acid supplement
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dry Eye Disease
Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease
The purpose of this study is to evaluate the clinical effectiveness and tolerability of SYSTANE® Complete in adult patients with dry eye disease.
- Trial name
- NCT03492541
- Testing
- Propylene glycol-based eye drops
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 134 people
- Sponsor
- Alcon Research
Aqueous Deficient Dry Eye, Meibomium Gland Dysfunction
Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation
Compare the objective tear film dynamic measurements in three different populations (MGD [Meibomium Gland Dysfunction], ADDE [Aqueous Deficient Dry Eye] and normal/control [non-dry eye]) and the subjective experience before and…
- Trial name
- NCT01128049
- Testing
- Subjective Questionnaire, Measurement with wavefront sensor (right eye, then left eye), Instill Saline Drop
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Keratoconjunctivitis Sicca
Trial of CF101 to Treat Patients With Dry Eye Disease
Eligible patients with dry eye will be treated with CF101 or placebo twice daily for 24 weeks. Disease activity will be assessed using evaluations of ocular surface integrity, tear production, and patient symptoms.
- Trial name
- NCT01235234
- Testing
- CF101
- Where
- Israel
- Volunteers
- 236 people
- Sponsor
- Can-Fite BioPharma
Aqueous Tear Deficiency, Meibomian Gland Dysfunction of Bilateral Eyes (Disorder)
Eyelid Androgen Treatment in Dry Eye
The purpose of this research study is to evaluate the effectiveness and safety of applying androgen sex hormone (i.e., testosterone) gel on the eyelids in the treatment of dry eye patients.
- Trial name
- NCT06154200
- Testing
- Testosterone gel 4.5%, Vehicle gel
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
DED, Aqueous-deficient Dry Eye Disease
Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.
This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.
- Trial name
- NCT07571330
- Testing
- Punctal plug occlusion
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Six Month Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator
In this study, the safety and effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator after 180 days of use in participants with aqueous tear deficiency will be evaluated.
- Trial name
- NCT02526290
- Testing
- Intranasal Lacrimal Neurostimulator (Oculeve)
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Oculeve, Inc.
Dry Eye, Sjogren's Syndrome
Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye
The study aims to test the safety of Repetitive Magnetic Stimulation (RMS) treatment for dry eye disease. Patients are asked to undergo a one-time treatment with Epitech Ocular Magnetic Stimulation Device on one eye in the first…
- Conditions
- Dry Eye, Sjogren's Syndrome, Aqueous Tear Deficiency, Meibomian Gland Dysfunction
- Trial name
- NCT03012698
- Testing
- Ocular Repetitive Magnetic Stimulation (RMS) treatment
- Where
- 3 sites in Israel
- Volunteers
- 29 people
- Sponsor
- Epitech Mag Ltd.
Dry Eye Syndrome, Keratoconjunctivitis Sicca
A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome
The purpose of this study is to compare acute tear production produced by the Oculeve Intranasal Lacrimal Neurostimulator with two control devices in participants with aqueous tear deficiency.
- Trial name
- NCT02680158
- Testing
- Oculeve Intranasal, Oculeve Extranasal
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Oculeve, Inc.