Clinical trials: Arrhythmia Atrial
Atrial Fibrillation (AF), Pacemaker Therapy
Left Bundle Branch Pacing vs Right Ventricular Pacing on AHRE Burden in Patients With Preserved LVEF
This prospective, randomized controlled trial aims to evaluate the effect of left bundle branch pacing (LBBP) compared with conventional right ventricular (RV) pacing on the cumulative duration (total time) of atrial high-rate…
- Conditions
- Atrial Fibrillation (AF), Pacemaker Therapy, Atrioventricular Block, Preserved Ejection Fraction
- Trial name
- LBBP-AHRE (NCT07250529)
- Testing
- Right Ventricular Pacing, Left Bundle Branch Pacing
- Where
- Greece
- Volunteers
- 244 people
- Sponsor
- University Hospital of Patras
Rheumatic Heart Disease
INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority
This program is a comprehensive evaluation of rheumatic valvular heart disease (RVHD), Atrial fibrillation (AF)/flutter and stroke.
- Trial name
- INVICTUS-ASA (NCT02832531)
- Testing
- Rivaroxaban (15 mg), Aspirin
- Sponsor
- Population Health Research Institute
Atrial Fibrillation
Evaluation of Predictive Factors for Recurrence of Persistent Atrial Fibrillation After Ablation
This is a single-center, retrospective, observational study based on data extracted from the medical records of patients who underwent a procedure for persistent atrial fibrillation ablation.
- Trial name
- FAIR (NCT06620575)
- Testing
- Atrial fibrillation ablation
- Where
- France
- Volunteers
- 542 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Atrial Flutter
Half-normal Saline in Atrial Flutter Ablation
To assess the acute and long-term efficacy of half-normal saline compared to normal saline for irrigation of open-irrigated catheters during catheter ablation for the treatment of cavotricuspid isthmus dependent atrial flutter.
- Trial name
- NCT04001530
- Testing
- Half Normal Saline 0.45% Infusion Solution Bag, Normal Saline 0.9% Infusion Solution Bag
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Sunnybrook Health Sciences Centre
Atrial Fibrillation
BTE and Pulsed Waveforms for Cardioversion of Atrial Fibrillation - Escalation Strategy and Manual Pressure
Background: A Danish study raised the question of the usefulness of escalating energy protocols compared to fixed high-energy protocols. Maximal energies are usually the final choice of the physicians.
- Trial name
- NCT05316753
- Testing
- Cardioversion with a pulsed biphasic waveform, Cardioversion with a biphasic truncated exponential waveform
- Where
- Bulgaria
- Volunteers
- 94 people
- Sponsor
- University National Heart Hospital
Paroxysmal Atrial Fibrillation
TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation
The TOCCASTAR Study will assess the safety and effectiveness of a contact force sensing catheter used for ablation in patients with paroxysmal atrial fibrillation.
- Trial name
- TOCCASTAR (NCT01278953)
- Testing
- Catheter ablation to treat paroxysmal atrial fibrillation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Abbott Medical Devices
Obstructive Sleep Apnea, Sleep Disorder (Disorder)
Start CPAP Therapy in Obstructive Sleep Apnea Patients After Atrial Fibrillation Ablation
Atrial fibrillation (AF) is one of the most common clinical arrhythmias. Catheter ablation is an effective therapeutic strategy; however, recurrence rates remain substantial, ranging from 20% to 45%.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder (Disorder), Atrial Fibrillation (AF), Sleep Disordered Breathing (SDB)
- Trial name
- STOP-AFib (NCT07444372)
- Testing
- Continuous Positive Airway Pressure (CPAP), Usual Care
- Where
- 30 sites in China
- Volunteers
- 658 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure
Atrioventricular Node Ablation in Patients With Atrial Fibrillation and Moderate Chronic Heart Failure
The purpose of this study is to determine whether cardiac resynchronization therapy (CRT) is superior to interventricular right ventricle (RV) septal pacing in respect of reverse remodeling (LV ESD) and morbidity in patients with…
- Trial name
- VISTA (NCT01512381)
- Testing
- Implantation of CRT device, Implantation of conventional VVI(R) pacemaker
- Where
- Russia
- Volunteers
- 11 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Atrial Fibrillation, Atrial Cardiomyopathy
Clinical Cohorts for Validation of New Digital Biomarkers
The MAESTRIA study is an international, multi-centre, non-interventional, observational registry. The main goal is to enrol a representative group of European patients diagnosed with Atrial Fibrillation (AF) to analyse clinical…
- Trial name
- MAESTRIA (NCT05855538)
- Where
- Germany
- Volunteers
- 515 people
- Sponsor
- Atrial Fibrillation Network
Atrial Fibrillation, Device Related Thrombus
Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study).
Single arm, prospective unblinded study on post Watchman LAA closure device implant anti-coagulation management at a primary center (Vanderbilt Medical Center) and up to 5 additional high volume LAA implant centers.
- Conditions
- Atrial Fibrillation, Device Related Thrombus, Left Atrial Appendage Thrombosis, Watchman LAA Closure Device
- Trial name
- DEA-LAA (NCT03539055)
- Testing
- Dabigatran Etexilate Oral Capsule
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
AV Block
Danish Randomized Trial on Leadless vs Transvenous Pacing
The purpose of this study is to evaluate the quality of life, patient acceptance and exercise capacity with leadless compared to transvenous pacing in elderly patients with new-onset high-grade atrioventricular block.
- Trial name
- DANVERS (NCT05856799)
- Testing
- Leadless Micra AV Transcatheter Pacing System, Transvenous Azure XT DR dual chamber pacemaker
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Atrial Fibrillation
Oral Anti-coagulants in Fragile Patients With Percutaneous Endoscopic Gastrostomy and Atrial Fibrillation (ORIGAMI) Pilot Study
Compelling evidences support the safety of direct oral anticoagulants (DOAC) compared to Vitamin K antagonists (VKA) in patients with non-valvular atrial fibrillation.
- Trial name
- ORIGAMI (NCT04271293)
- Testing
- Edoxaban
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiovascular Diseases, Cardiac Arrhythmia
Solutions for Atrial Fibrillation Edvocacy (SAFE)
The aim of this demonstration project is to create an additional access point in the community at local pharmacies for atrial fibrillation screening, detection, and referral to physicians for follow-up and initiation of…
- Conditions
- Cardiovascular Diseases, Cardiac Arrhythmia, Atrial Fibrillation
- Trial name
- SAFE (NCT05067114)
- Testing
- Screening, detection and referral for atrial fibrillation
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- American Pharmacists Association Foundation
Atrial Fibrillation
Concomitant Treatment of Permanent Atrial Fibrillation
RESTORE-SR study is a multi-center, prospective, nonrandomized study with case matched concurrent controls to evaluate the safety and efficacy of the AtriCure Bipolar System
- Trial name
- RESTORE SR (NCT00566787)
- Testing
- Surgical bipolar radiofrequency ablation using the AtriCure Bipolar System
- Where
- 10 sites in United States
- Volunteers
- 39 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation, Stroke
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial
EAST prospectively tests the hypothesis that an early, structured rhythm control therapy based on antiarrhythmic drugs and catheter ablation can prevent atrial fibrillation (AF) related complications in patients with AF when…
- Trial name
- EAST (NCT01288352)
- Testing
- early standardised rhythm control
- Where
- 11 sites in Belgium, Czechia and 9 more
- Volunteers
- 2,789 people
- Sponsor
- Atrial Fibrillation Network
Fibrillation, Atrial
Evaluation of Efficacy and Safety of Lovaza (Omega-3-Acid Ethyl Esters) in Recurrent, Symptomatic Atrial Fibrillation
The purpose of this study is to evaluate efficacy and safety of Omacor (omega-3-acid ethyl esters) in patients with recurrent, symptomatic atrial fibrillation.
- Trial name
- NCT00402363
- Testing
- omega-3-acid ethyl esters
- Where
- 178 sites in United States
- Volunteers
- 663 people
- Sponsor
- GlaxoSmithKline
Atrial Fibrillation
MCG In Long QT Syndrome
The primary objective of this observational study is to evaluate whether magnetocardiography (MCG) findings more accurately predict clinical outcomes in patients with acquired Long QT syndrome compared to ECG.
- Trial name
- NCT07270211
- Testing
- Magnetocardiography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Atrial Fibrillation
A Study to Assess the Effectiveness of an Atrial Fibrillation (AF) Risk Prediction Algorithm and Diagnostic Test in Identifying Patients With AF.
This is a trial to assess the effectiveness of an atrial fibrillation (AF) risk prediction algorithm and diagnostic test for the identification of patients with atrial fibrillation
- Trial name
- PULsE AI (NCT04045639)
- Where
- 6 sites in United Kingdom
- Volunteers
- 260 people
- Sponsor
- Bristol-Myers Squibb
Atrial Fibrillation
The Ottawa AF Cardioversion Protocol
Atrial fibrillation is an abnormal heart rhythm in which the top chambers of the heart (the atrial chambers) beat very fast. Electrical cardioversion is a technique to convert heart rhythm from AF to normal rhythm.
- Trial name
- NCT02192957
- Testing
- Lifepak 20E Defibrillator, Licence No: 61944
- Where
- Canada
- Volunteers
- 389 people
- Sponsor
- David Birnie
Atrial Fibrillation
Study of Left Atrial Appendage Closure in Patients With Atrial Fibrillation - III
This study is a prospective, multicenter, non-randomized trial of a stand-alone procedure for left atrial appendage exclusion in patients with atrial fibrillation at risk for embolic events who are contraindicated for or…
- Trial name
- PLACE III (NCT01680757)
- Testing
- LARIAT Suture Delivery Device and Accessories
- Where
- 12 sites in United States, Germany and 1 more
- Sponsor
- University of California, San Francisco