Clinical trials: Arterial Calcification
Coronary Atherosclerosis Due to Calcified Coronary Lesion, Chronic Total Occlusion of Coronary Artery
The XLIMUS-DES in Very Complex Lesions
Stent delivery failure occurs in 4% of all percutaneous coronary interventions (PCI) and >90% of these failures are due to vessel tortuosity and/or calcification.
- Trial name
- NCT02360020
- Testing
- XLimus
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Clinica Mediterranea
PAD
Study of Peripheral Arterial Calcification
Aim of the work : 1. Using different calcification scoring systems to investigate the association between arterial calcification and clinical outcome following endovascular therapy
- Trial name
- NCT04108806
- Testing
- Endovascular therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Calcified Atheroma, Coronary Artery Disease
ShOckwave ballooN or Atherectomy With Rotablation in Calcified Coronary Artery Lesions, the SONAR Trial
Percutaneous coronary interventions (PCI) is intended to relieve myocardial ischemia by improving blood flow in the epicardial coronary arteries.
- Trial name
- SONAR (NCT05208749)
- Testing
- Rotablation of shockwave
- Where
- Belgium
- Volunteers
- 170 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Calcification
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
Until 2013 the reported incidence of chronic kidney disease varied widely between countries, reporting the highest prevalence Taiwan, the region of Jalisco in Mexico and United States, with 458, 421 and 363 individuals per…
- Trial name
- NCT04247087
- Testing
- phytomenadione
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Mexicano del Seguro Social
Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk
Breast Artery Calcification (BAC) and Female Cardiovascular Disease
The investigators are recruiting women with and without Breast Artery Calcification (BAC) on their mammograms. Each participant in the study will undergo bloodwork at a Northwell Health lab, a cardiac CT scan, and fill out some…
- Conditions
- Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk, Cardiovascular Disease Prevention
- Trial name
- NCT07809932
- Testing
- Cardiac CT Scan, Bloodwork
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Coronary Artery Calcification
Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)
This is a prospective and multicenter clinical investigation aiming to evaluate the safety and effectiveness of coronary intravascular lithotripsy system for the treatment of patients with coronary calcification.
- Trial name
- NCT05818098
- Testing
- Intravascular Lithotripsy System of Shanghai MicroPort Rhythm
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Calcified Coronary Artery Disease (Grade 3)
A ComparIson of Strategies to PrepAre SeveRely CALCified Coronary Lesions
The objective of this prospective, multicenter, randomized, open-label trial is to evaluate the completeness of stent expansion following a strategy of lesion preparation with either a Super High-Pressure NC PTCA Balloon (OPN NC)…
- Trial name
- ISAR-CALC (NCT03487432)
- Testing
- Super High-Pressure NC PTCA Balloon (OPN NC), Scoring PTCA Balloon (NSE Alpha)
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 74 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Mammography, Vascular Calcification
Mammography and Breast Arterial Calcification: An Information-Sharing Trial
The purpose of this research study was to determine the potential benefits of adding information on patients' breast arterial calcification (BAC) results to the standard results letter women receive after mammography.
- Trial name
- NCT04983875
- Testing
- BAC-Enhanced Letter, Waitlist Control
- Where
- United States
- Volunteers
- 5,492 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gene Mutations, Pseudoxanthoma Elasticum
ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency
The purpose of this study (Study INZ701-304 [ADAPT]) is to assess the long-term safety of INZ-701 in patients with ENPP1 Deficiency or ABCC6 Deficiency who have received INZ-701 in an existing clinical study and choose to…
- Conditions
- Gene Mutations, Pseudoxanthoma Elasticum, Arterial Calcification, Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency
- Trial name
- NCT06462547
- Testing
- INZ-701
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 22 people
- Sponsor
- Inozyme Pharma
Peripheral Arterial Disease
Delivery of Yamani-15/5 Chemical Solution for PAD
This is a feasibility pilot study to evaluate the impact of local delivery of Yamani-15/5 (combination of L-Lactic acid 15% and D-Gluconic acid 5%) on vascular calcification of lower extremities in patients with severe peripheral…
- Trial name
- NCT02539303
- Testing
- Yamani-15/5 chemical solution
- Sponsor
- Mayo Clinic
Coronary Artery Calcification, Coronary Artery Disease
Intravascular Imaging-Guided Intravascular Lithotripsy for Severe Coronary Calcified Lesions.
This study aims to investigate the efficacy and safety of intravascular lithotripsy (IVL) balloon in treating coronary calcified lesions at our center.
- Trial name
- NCT07444346
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Coronary Artery Disease
AI-Based CT Analysis of Coronary Plaque Evolution
This retrospective, multicenter, observational study will evaluate an artificial intelligence-based system for quantitative assessment and risk stratification of coronary atherosclerotic plaque.
- Trial name
- AI-CT-PLAQUE (NCT07886996)
- Where
- 5 sites in China
- Volunteers
- 326 people
- Sponsor
- Zhejiang Hospital
Peripheral Arterial Disease
Investigational Study of SWM-831 to Treat Moderate and Severely Calcified Femoropopliteal Arteries
Disrupt PAD Japan is a prospective, multi-center, single-arm study of SWM-831 to treat moderate and severely calcified femoropopliteal arteries, prior to DCB or stenting.
- Trial name
- NCT06938854
- Testing
- Peripheral Intravascular Lithotripsy (IVL)
- Where
- 10 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Shockwave Medical, Inc.
Coronary Artery Calcification
Association Between Non-alcoholic Fatty Liver Disease (NAFLD) and Coronary Artery Calcification
Coronary artery disease are 8 times more prevalent in patients with NAFLD then the general population and are being considered the most common cause of death.
- Trial name
- NCT01158066
- Testing
- CT Cardiac
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Ziv Hospital
Calcinosis, Arteriosclerosis
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
The purpose of the study is to evaluate the effects of two phosphate binders, PhosLo and sevelamer, on heart calcification in dialysis patients.
- Conditions
- Calcinosis, Arteriosclerosis, Hyperparathyroidism, Secondary
- Trial name
- NCT00211939
- Testing
- calcium acetate, sevelamer, atorvastatin
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Nabi Biopharmaceuticals
Chronic Total Occlusion of Coronary Artery, Calcification
Calcification on CTCA of a CTO and PCI Outcomes
A chronic total occlusion (CTO) is present in 15-20% of patients who are referred for invasive coronary angiography. CTO Percutaneous Coronary Intervention (PCI) procedure success rates have increased over the years and can be as…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Calcification, Computed Tomography Angiography
- Trial name
- NCT06414551
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Coronary Artery Calcification
Toe-brachial Index and Coronary Calcification in Type 1 and 2 Diabetes
Diabetes is not a coronary risk equivalent, despite cardiovascular disease is the most common cause of death in diabetes. So, to identify diabetic patients at high cardiovascular risk is necessary.
- Trial name
- ACCoDiab (NCT03920683)
- Testing
- Data collection
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Coronary Artery Atherosclerosis
Intravascular Imaging Evaluated Calcified Nodule China Registry
What is this study about? This is a nationwide research study in China focused on understanding a specific type of challenging plaque in heart arteries called a Calcified Nodule (CN).
- Conditions
- Coronary Artery Disease, Coronary Artery Atherosclerosis, Coronary Calcified Nodules, Coronary Calcification
- Trial name
- NCT07262359
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets
ENERGY 2: Evaluation of the Efficacy and Safety of INZ-701 in Infants With ENPP1 Deficiency
The primary purpose of ENERGY 2 (Study INZ701-105) is to assess the efficacy and safety of INZ-701 in infants with ENPP1 Deficiency.
- Conditions
- Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency, Autosomal Recessive Hypophosphatemic Rickets, Generalized Arterial Calcification of Infancy 1
- Trial name
- NCT07473973
- Testing
- INZ-701
- Where
- 8 sites in Brazil, France and 6 more
- Volunteers
- 2 people
- Sponsor
- Inozyme Pharma
Coronary Artery Disease, Coronary Calcification
Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment
The NODULE-SHOCK trial is a prospective, investigator-initiated, single-center, randomized controlled trial designed to compare the efficacy of intravascular lithotripsy (IVL) with or without rotational atherectomy (RA) in…
- Trial name
- NODULE-SHOCK (NCT07000045)
- Testing
- Intravascular lithotripsy, Rotational atherectomy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Annapoorna Kini