Clinical trials: Arterial Hypotension
Hypotension, Orthostatic
A Study for Patients With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright…
- Trial name
- NCT00046475
- Testing
- Midodrine Hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Shire
Hypotension
Median Sevoflurane Concentration for Hypotension Between Young and Elderlypatients: Adaptive Clinical Trial
Two arms: elder group, young group. Dixon's up and down adaptive methodology for ED50. Executed after Anesthesia induction for 10min without touching the patient after starting mechanical ventilation.
- Trial name
- NCT03595319
- Testing
- Sevoflurane
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brasilia University Hospital
Hypotension and Shock, Wounds and Injuries
Prehospital Management of Hypotensive Trauma in HEMS
Up to today, inadequate evidences and knowledge exist about the best prehospital management of hypotensive trauma patients and its clinical consequence on the in-hospital recovery and mortality.
- Conditions
- Hypotension and Shock, Wounds and Injuries, Emergencies, Critical Care
- Trial name
- SPITFIRE (NCT04760977)
- Where
- 16 sites in Italy
- Volunteers
- 1,268 people
- Sponsor
- Azienda Usl di Bologna
Hypotension During Surgery, NGAL
Controlled Hypotension and Renal Injury During Septoplasty
This prospective randomized single-blind study investigated the effects of two different mean arterial pressure (MAP) targets during controlled hypotension on renal injury in patients undergoing septoplasty.
- Conditions
- Hypotension During Surgery, NGAL, Kidney Injury
- Trial name
- NCT07662577
- Testing
- Controlled Hypotension (MAP 50-57 mmHg), Controlled Hypotension (MAP 58-65 mmHg)
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Intraoperative Hypotension
Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia
This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia.
- Trial name
- NCT07301307
- Testing
- Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software, Conventional Intraoperative Hemodynamic management
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Hypotension, Hypoxemia
Point of Care Ultrasound Evaluation in the Post-Anesthesia Unit
The purpose of this observational research study is to examine how point-of care ultrasound affects the workup and management of perioperative complications for specific clinical scenarios of low blood pressure (hypotension), low…
- Conditions
- Hypotension, Hypoxemia, Altered Mental Status, Urine Output Low
- Trial name
- NCT04410757
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Loma Linda University
Anesthesia, Hemodynamic Instability
Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients
The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of…
- Trial name
- NCT06535230
- Testing
- Manual anesthesia induction, Anesthesia induction with Target controlled infusions (TCI), Hemodynamic monitoring with pressure recording analytical method (PRAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Blood Pressure, Intraoperative Hypotension
Personalized Blood Pressure Management
The aim of this research project is to find out whether a personalized definition of the lower blood pressure threshold based on the individual blood pressure profile by means of preoperative 24-hour blood pressure measurement…
- Conditions
- Blood Pressure, Intraoperative Hypotension, Postoperative Complications
- Trial name
- IMPROVE (NCT03442907)
- Testing
- 24 hour blood pressure measurement, fluids, vasopressors, Standard of Care
- Where
- Germany
- Volunteers
- 368 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypotension
Tricuspid Annular Plane Systolic Excursion to Predict Arterial Hypotension Caused by Spinal Anesthesia in Caesarean Section
This cross-sectional blinded study was planned to be conducted in Aydın Gynecology and Pediatrics Hospital between June 2023 and September 2023.
- Trial name
- CESERAN TAPSE (NCT05874687)
- Testing
- hypotension + treat
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people
- Sponsor
- Aydin Maternity and Child Health Hospital
Postoperative Delirium (POD), Intraoperative Hypotension
Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac Surgery
In older patients having surgery, postoperative delirium (an acute disturbance in awareness, attention, or cognition) is common and associated with short-term and long-term morbidity and mortality.
- Trial name
- ASPIRE-85 (NCT07713121)
- Testing
- MAP at 85 mmHg or higher (intervention group), MAP at 65 mmHg or higher (control group)
- Where
- Germany
- Volunteers
- 3,432 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypotension During Surgery, Geriatric Patient
Relationship Between Grip Strength and Intraoperative Hemodynamic Parameters
In geriatric anesthesia, hand grip strength is used as an important biomarker to evaluate the general health status of elderly patients.
- Conditions
- Hypotension During Surgery, Geriatric Patient, Hand Grip Strength
- Trial name
- NCT06679933
- Testing
- Hand grip strength measurament
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Orthostatic Hypotension, Sarcopenia
Sarcopenia and Orthostatic Hypotension
Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries.
- Trial name
- NCT03732716
- Testing
- blood pressure measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Post-induction Hypotension, Intestinal Obstruction
SV and IVC Collapsibility Index to Predict Postinduction Hypotension
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow…
- Trial name
- NCT07742904
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Septic Shock, Sepsis-associated Hypotension
Hypertonic Saline and Terlipressin for Sepsis-associated Hypotension
In hypotensive septic patients with controlled source, an hemodynamic management protocol including hypertonic saline (HS)and terlipressin improves MOD (Multiple Organ Dysfunction) Score by at least 3 points compared to the use…
- Trial name
- HYSATESS-p (NCT01271114)
- Testing
- Hypertonic Saline and Terlipressin, Normal saline and norepinephrine
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Hospital General de Ciudad Real
Intraoperative Hypotension
Hypotension Prediction Index (HPI) in Lung Resections
Perioperative hypotension is a risk factor for perioperative complications. Advances in machine learning and artificial intelligence have produced an algorithm that predicts the occurrence of hypotension episodes by analyzing an…
- Trial name
- NCT06202638
- Testing
- HemoSphere monitor with Acumen Hypotension Prediction Index Software
- Where
- 3 sites in Greece, Poland
- Volunteers
- 77 people
- Sponsor
- John Paul II Hospital, Krakow
Polyneuropathy, Amyloid, Neuropathic Pain
Screening for the Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR FAP)
An International, multicenter, epidemiological observational study investigating the prevalence of Transthyretin-Related Familial Amyloidotic Polyneuropathy (TTR-FAP) in participants with small fiber polyneuropathy of no obvious…
- Conditions
- Polyneuropathy, Amyloid, Neuropathic Pain, Cardiac Failure, Orthostatic Hypotension
- Trial name
- TRAP2-1 (NCT01705626)
- Where
- 11 sites in Austria, Hungary and 4 more
- Volunteers
- 500 people
- Sponsor
- CENTOGENE GmbH Rostock
Perioperative Hypotension, Prevention
A Comparison of Prevention of Hypothermia in Pediatric Patient Between Wrapping With Cotton and Plastic.
Hypothermia leads to increased morbidity and mortality. Heat loss mainly occurs during anesthesia and surgery. Therefore prevention of hypothermia in pediatric patients undergoing general anesthesia is very important.
- Conditions
- Perioperative Hypotension, Prevention, Child
- Trial name
- NCT00231699
- Testing
- Plastic wrap (study group) and cotton (control group) wrap.
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Post-spinal Hypotension
Ultrasonographic Assessment of Neck Vessels as Predictors of Spinal Anesthesia Induced Hypotension in Elderly
Spinal anesthesia induces sympathetic blockade and venodilation, thus reducing venous return and the cardiac output. Therefore, assessment of intravascular volume deficit before anesthesia might predict a critical decrease in…
- Trial name
- NCT05078606
- Testing
- IJV Ultrasonography, Carotid Intima Media Thickness, Spinal anesthesia
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Cairo University
Hypotension
Sequential Compression Device (SCD) for Stabilizing Hemodynamics in the Beach Chair Position
This study is a 3-legged randomized study examining whether during shoulder surgery performed in the beach chair position active compressions of the lower leg with a sequential compression device (SCD) have a superior effect on…
- Trial name
- NCT01680393
- Testing
- Sequential compression device, TED stockings
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Bispebjerg Hospital
Pregnant Women, Pain
Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia
Over the past 15 years, cesarean delivery is most commonly performed under spinal anesthesia using hyperbaric bupivacaine which provides an adequate sensory and motor block.
- Conditions
- Pregnant Women, Pain, Hypotension
- Trial name
- NCT02973048
- Testing
- Hyperbaric bupivacaine, Hyperbaric prilocaine
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
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