Clinical trials: Arterial Insufficiency
Placental Insufficiency
Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation
To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first…
- Trial name
- ASAP (NCT01616615)
- Testing
- Aspirin
- Where
- 3 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Sara Varea
Bleeding Disorder, Stroke, Ischemic
XIENCE 28 Global Study
XIENCE 28 Global Study is a prospective, single arm, multi-center, open label, non-randomized trial to further evaluate the safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of…
- Conditions
- Bleeding Disorder, Stroke, Ischemic, Stroke Hemorrhagic, Hematological Disease
- Trial name
- NCT03355742
- Testing
- XIENCE, DAPT
- Where
- 52 sites in Austria, Belgium and 11 more
- Volunteers
- 963 people
- Sponsor
- Abbott Medical Devices
Acute Kidney Injury (Nontraumatic), Coronary Artery Disease
Contrast RISK (Reducing Injury Sustained by Kidneys)
Diagnostic and therapeutic cardiac catheterization procedures are important interventions to reduce the risk of death, avoid future cardiovascular events, and improve quality of life of people with heart disease.
- Trial name
- Contrast RISK (NCT03453996)
- Testing
- Intervention, Control
- Where
- 3 sites in Canada
- Volunteers
- 7,280 people
- Sponsor
- University of Calgary
Death, Postoperative Complications
Study to Determine the Impact of Intraoperative Blood Pressure Management on Postoperative Outcomes (MAP-ALIVE)
The purpose of this study is to determine 1. whether intraoperative hypotension or hypertension is independently associated with postoperative mortality and morbidity 2.
- Conditions
- Death, Postoperative Complications, Myocardial Infarction, Stroke
- Trial name
- MAP-ALIVE (NCT02019342)
- Testing
- FACE quality improvement initiative (see below), Pre-quality improvement initiative
- Where
- 2 sites in United States
- Sponsor
- Washington University School of Medicine
Brain Disease, Vertebral Artery Stenosis
A Prospective, Experimental, Multicenter, Open-label, Randomized, Controlled Trial of 3-month Dual Antiplatelet Therapy Followed by Ticagrelor Versus 6-month Dual Antiplatelet Therapy Followed by Ticagrelor After Implanting Bridge
To compare the incidence of the composite endpoints of non-fatal ischaemic stroke, transient ischaemia (TIA) and all-cause mortality at 12-month follow-up after implantation of Bridge for the treatment of symptomatic vertebral…
- Trial name
- NCT06301776
- Testing
- Ticagrelor
- Where
- China
- Volunteers
- 560 people
- Sponsor
- The Fourth Affiliated Hospital of China Medical University
Acute Kidney Injury
Preoperative Level of Hemoglobin A1c and Acute Kindey Injury After Coronary Artery Bypass Grafting Surgery
Background: The development of acute kidney injury (AKI) is an important indicator of clinical outcomes after cardiac surgery. Elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients…
- Trial name
- NCT05390281
- Testing
- increase in serum creatinine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
End-stage Renal Disease, Critical Limb Ischemia
Open Versus Endovascular Revascularization in Patients With End-stage Renal Disease
Treatment of patients with end-stage renal disease and critical limb ischemia still poses challenges to vascular medicine due to limited survival, comorbidities and infrapopliteal involvement of arteriosclerosis in these…
- Trial name
- OERESRD (NCT03293589)
- Testing
- open revascularization, endovascular revascularization
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- University Hospital Erlangen
Peripheral Arterial Disease, Chronic Kidney Diseases
Preventing Kidney Injury Using Carbon Dioxide as Contrast Medium in Patients With Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) Having Arterial Intervention
This research trial will test whether using carbon dioxide as a contrast medium during surgery to open blocked leg arteries can prevent kidney injury.
- Conditions
- Peripheral Arterial Disease, Chronic Kidney Diseases, Acute Kidney Injury
- Trial name
- KID (NCT07891988)
- Testing
- Iodinated contrast medium, CO2 automated injector contrast medium
- Where
- 6 sites in United Kingdom
- Volunteers
- 184 people
- Sponsor
- University of Leicester
WOUNDS
Efficacy Study of Ultrasound-Assisted Debridement to Influence Wound Healing
The UltraHeal Study is a randomized controlled trial to compare healing response of low frequency contact ultrasonic-assisted debridement in addition to best practice wound care to best practice wound care alone in a Vascular…
- Trial name
- UltraHeal (NCT01973361)
- Testing
- Ultrasound debridement, Best practice wound care
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Erectile Dysfunction Due to Arterial Insufficiency
Incidence of Male Pudendal Artery Stenosis in Suboptimal Erections Study
The purpose of this study is to determine the proportion of men with known or suspected coronary artery disease (CAD) and/or peripheral arterial disease (PAD) that have angiographic identifiable erectile related artery (ERA)…
- Trial name
- IMPASSE (NCT01341483)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Medtronic Endovascular
Contrast-induced Nephropathy, Acute Kidney Injury
Proenkephalin for Prediction of Contrast-Associated Kidney Events
Currently, contrast-induced kidney injury cannot be diagnosed on the day of cardiac catheterization. Recently, proenkephalin (penKid) was introduced as a new glomerular filtration marker.
- Conditions
- Contrast-induced Nephropathy, Acute Kidney Injury, Coronary Artery Disease
- Trial name
- PANCAKE (NCT03989505)
- Testing
- blood-draw for biomarker analyses
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Dr. med. Mahir Karakas
Coronary Insufficiency
Magnetic Resonance Diabetic Cardiac Stress Imaging
The aim of the study is to assess the efficacy of cardiac MRI to detect coronary disease in diabetic patients. Cardiac MRI will be compared to myocardial scintigraphy with is the method being used in current practice.
- Trial name
- MRDiabetics (NCT00797082)
- Testing
- MRI, MPS
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Risk Pregnant Women, Placental Insufficiency
Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
This is a Multicenter, randomized, open-label, parallel groups study to test the hypothesis that prophylactic low molecular weight heparin (LMWH) (enoxaparin) initiated before 14 weeks of gestation could improve maternal and…
- Conditions
- High Risk Pregnant Women, Placental Insufficiency, Preeclampsia
- Trial name
- HOPPE (NCT01388322)
- Testing
- Enoxaparin
- Where
- 4 sites in Spain
- Volunteers
- 361 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Kidney Disease Stage 3 and 4, Peripheral Artery Disease (PAD)
Exercise Activity to Improve Mobility in Patients With CKD and PAD
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study.
- Trial name
- EXACT-CKDPAD (NCT06621264)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Control (Standard treatment)
- Where
- 3 sites in Italy
- Volunteers
- 124 people
- Sponsor
- University Hospital of Ferrara
Atherosclerosis, Kidney Failure
Study Comparing Effect On Carotid Atherosclerosis Following Conversion From Tacrolimus To Sirolimus Post-Transplant In Kidney Transplant Patients
The purpose of this study is to determine whether immunosuppression by tacrolimus, mycophenolate mofetil, and prednisone compared to conversion to sirolimus, mycophenolate mofetil, and prednisone affect the progression of…
- Trial name
- NCT00311311
- Testing
- tacrolimus, mycophenolate mofetil, prednisone
- Where
- 8 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- Pfizer
Arterial Hypertension, Heart Rhythm Disorders
Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the…
- Conditions
- Arterial Hypertension, Heart Rhythm Disorders, Valvular Heart Diseases, Heart Failure
- Trial name
- NCT07396792
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Artery Disease, Myocarditis
A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease
This study aims to identify and assess new CMR techniques that can improve current CMR protocols.
- Conditions
- Coronary Artery Disease, Myocarditis, Infiltrative Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- NCT04464655
- Where
- Canada
- Volunteers
- 2,130 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Coronary Artery Disease
IVUS Guided PCI in Patients With Chronic Kidney Disease
The incidence of contrast-induced nephropathy (CIN) is high (> 25%) in patients with severe chronic renal disease (CKD) who undergo a percutaneous coronary procedure.
- Trial name
- SPEED (NCT06813534)
- Testing
- Intravascular Ultrasound guided PCI
- Where
- 2 sites in France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mitral Valve Insufficiency, Mitral Valve Regurgitation
Pivotal Study of a Percutaneous Mitral Valve Repair System
EVEREST II Randomized Controlled Trial (RCT) is a prospective, multi-center, randomized study of the MitraClip® System in the treatment of mitral valve regurgitation, randomizing patients to MitraClip or mitral valve surgery.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- EVERESTIIRCT (NCT00209274)
- Testing
- Percutaneous mitral valve repair using MitraClip implant, Mitral valve repair or replacement surgery
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Abbott Medical Devices
Stroke, Coronary Arterial Disease (CAD)
Algae Effects in Markers of Cardiovascular Risk and Gut Microbiome
The Western diet, rich in fat and sugar, contributes to cardiovascular risk and alters the body metabolism, specifically through the modulation of the microbiome.
- Conditions
- Stroke, Coronary Arterial Disease (CAD), Myocardial Infarction (MI), Diabetes Mellitus
- Trial name
- CALGUT (NCT07173062)
- Testing
- Spirulina Arthrospira platensis (microalgae), Gelidium corneum
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Universidade do Porto