Clinical trials: Arterial Ischemic Stroke
Cerebral Small Vessel Diseases, Stroke, Lacunar
LACunar Intervention (LACI-2) Trial-2
About 35,000 people each year in the UK have a type of stroke, called 'lacunar' or 'small vessel' stroke, which is different to other common types of stroke and for which there is no proven treatment.
- Trial name
- LACI-2 (NCT03451591)
- Testing
- Isosorbide Mononitrate XL (ISMN), Cilostazol, ISMN XL and Cilostazol
- Where
- United Kingdom
- Volunteers
- 363 people
- Sponsor
- University of Edinburgh
Stroke
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood.
- Trial name
- APEDOC (NCT06446960)
- Testing
- Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bulbar Palsy
Efficacy of Stellate Ganglion Block in Dysphagic Patients With Bulbar Palsy After Ischemic Stroke
This is a randomized controlled study, including dysphagic patients with bulbar palsy after ischemic stroke who were received in the department of rehabilitation medicine in 3 hospitals in China.
- Trial name
- NCT06225076
- Testing
- Comprehensive rehabilitation, Stellate ganglion block, Lidocaine Hydrochloride
- Where
- China
- Sponsor
- Zeng Changhao
Ischemic Stroke
Efficacy and Safety of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
This clinical trial is designed to evaluate the efficacy and safety of the combination therapy of SP-8203 (Otaplimastat) and recombinant tissue Plasminogen Activator (rtPA) standard of care.
- Trial name
- SP-8203-2002 (NCT04479449)
- Testing
- SP-8203
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Ischemic Stroke, Small Vessel Cerebrovascular Disease
Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke
Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels…
- Conditions
- Ischemic Stroke, Small Vessel Cerebrovascular Disease, Cholesterol, LDL, Secondary Prevention
- Trial name
- SVO70 (NCT06649240)
- Testing
- Statins and/or Ezetimibe, PCSK9 inhibitor
- Where
- 46 sites in South Korea
- Volunteers
- 4,016 people
- Sponsor
- Seoul National University Hospital
Ischemic Cerebrovascular Accident
Clopidogrel for Acute Ischaemia of Recent Onset
Evaluate the role of loading Clopidogrel in acute ischemic stroke in improving neurological outcome of stroke in cases patients will be non-eligible for, or declined, treatment with or intravenous thrombolysis with rTPA, rTPA is…
- Trial name
- CAIRO (NCT02776540)
- Testing
- Clopidogrel, Aspirin
- Where
- Egypt
- Volunteers
- 188 people
- Sponsor
- Ain Shams University
Acute Ischemic Stroke
A Feasibility Study for the DAISe EZ Thrombectomy Device - Pacific
The study is a prospective, multi-center, single arm, feasibility study that will enroll a maximum of 20 subjects. A maximum of 5 investigational centers in Australia will participate.
- Trial name
- NCT06042335
- Testing
- DAISe EZ
- Volunteers
- 20 people
- Sponsor
- MIVI Neuroscience, Inc.
Bleeding, Ischemic Stroke
The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The purpose of this study is to determine whether Plasma Factor VIII Levels are related to the treatment of bleeding in ischemic stroke（IS）.
- Trial name
- NCT02677818
- Where
- China
- Sponsor
- Zhujiang Hospital
Ischemic Stroke
Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke
Non-invasive brain stimulation (tDCS) such as transcranial direct current stimulation (TDCS) has been reported to be effective in improving motor performance and safe in participants with cerebral infarction.
- Trial name
- DAS (NCT04938076)
- Testing
- Transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Incheon St.Mary's Hospital
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Ischemic Stroke, Acute
Brain-Oscillation-Synchronized Stimulation to Enhance Motor Recovery in Early Subacute Stroke
We will investigate the therapeutic efficacy of EEG-synchronized noninvasive repetitive transcranial magnetic stimulation (rTMS) in the early subacute phase after ischemic stroke to improve upper limb motor rehabilitation.
- Trial name
- Boss-Stroke (NCT05600374)
- Testing
- Bossdevice
- Where
- 4 sites in Germany
- Volunteers
- 144 people
- Sponsor
- University Hospital Tuebingen
Symptomatic Chronic Middle Cerebral Artery Occlusion, Infarction, Middle Cerebral Artery
Extracranial-intracranial Bypass Surgery for Symptomatic Chronic Middle Cerebral Artery Occlusion: the CMOSS-2 Trial
The CMOSS-2 trial is a government-funded, prospective, multicenter, randomized controlled trial. It will recruit symptomatic chronic occlusion of the middle cerebral artery in patients with severe hemodynamic insufficiency.
- Trial name
- NCT05899582
- Testing
- Extracranial-Intracranial Bypass Surgery, Medical treatment alone
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke, Hemorrhagic Stroke
A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1)
Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease.
- Trial name
- iCOOL 1 (NCT01573117)
- Testing
- RhinoChill, Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Cerebral Vascular Accident (CVA)
Predictive Value of Copeptin in the Diagnosis of Acute Ischemic Stroke
In the USA, every year 795,000 patients suffer a cerebral vascular accident (CVA), which represents a yearly cost of $73.7 billion.
- Trial name
- NCT01960478
- Testing
- (for each intervention), Blood test
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Ischemic Stroke, Stroke Rehabilitaion
Neurological Rehabilitation and Neuroplasticity After Ischemic Stroke
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke.
- Trial name
- NCT07899710
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Ischemic Stroke
Safety and Efficacy of Two Doses of SP-8203 in Patients With Ischemic Stroke Requiring rtPA
The current study aims to evaluate the safety of SP-8203, designing in two stages (stage-1, stage-2) to evaluate the safety and efficacy of the combination therapy of SP-8203 and rtPA for the occurrence of cerebral hemorrhage in…
- Trial name
- SP-8203-2001 (NCT02787278)
- Testing
- SP-8203 High dose, SP-8203 Low dose
- Where
- 8 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Ischemic Stroke, Intracerebral Haemorrhage
Head Position in Stroke Trial (HeadPoST)
This study is an investigator-initiated and conducted, international collaborative, regionally organised, multicentre, prospective, cluster randomised, crossover, blinded outcome assessment study to compare the effectiveness of…
- Trial name
- HeadPoST (NCT02162017)
- Testing
- The lying flat (0°) head position for 24 hours, The sitting-up (≥30°) head position for 24 hours
- Where
- Australia
- Volunteers
- 11,096 people
- Sponsor
- The George Institute
Ischemic Stroke
Functional Prognosis in Patients With Ischemic Stroke According to the Therapeutic Strategy Used
The current management of ischemic stroke is based on different strategies that may be combined: intravenous thrombolysis in a stroke ICU, intravenous thrombolysis in a telemedicine procedure, endovascular thrombectomy.
- Trial name
- PARADISE (NCT02856074)
- Testing
- prise de sang, quality of life questionnaire
- Where
- France
- Volunteers
- 821 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Ischemic Stroke, Transient Ischemic Attack
Vascular Cognitive Decline and Dementia
The ENIGMA study is a single-centre prospective clinical observational study with the aim to investigate vascular contributions to cognitive decline and dementia.
- Trial name
- ENIGMA (NCT06257823)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Aarhus University Hospital