Clinical trials: Arterial Ischemic Stroke
Stroke, Chronic Stroke
Virtual Physical Activity Seated Exercise - Phase 2
This study will determine the acceptability of delivering seated exercises online and if seated exercises can improve balance, mobility, quality of life, and cardiometabolic health in those living with a stroke related mobility…
- Conditions
- Stroke, Chronic Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- V-PASE (NCT05724823)
- Testing
- Virtual Physical Activity Seated Exercises (V-PASE)
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Coronary Artery Disease
Sonolysis in Risk Reduction of Symptomatic and Silent Brain Infarctions During Coronary Stenting
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- NCT02351050
- Testing
- Sonolysis
- Where
- Slovakia
- Volunteers
- 144 people
- Sponsor
- University Hospital Ostrava
Carotid Artery Disease, Carotid Artery Stenosis
Neurological Outcome With Carotid Artery Stenting
The purpose of this study is to determine how well patients undergoing carotid artery angioplasty and/or stent-supported angioplasty for the treatment of carotid artery stenosis will perform on a battery of tests to assess brain…
- Conditions
- Carotid Artery Disease, Carotid Artery Stenosis, Stroke, Transient Ischemic Attack
- Trial name
- CAS (NCT00597974)
- Testing
- Angioplasty, Stent, Neurological and neuropsychological evaluations
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Columbia University
Type2 Diabetes, Myocardial Infarction
Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors and Risk of Cardiovascular Events
The purpose of this study is to compare the risk of cardiovascular events associated with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in comparison with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors among…
- Conditions
- Type2 Diabetes, Myocardial Infarction, Ischemic Stroke, Cardiovascular Death
- Trial name
- NCT03939624
- Testing
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors, Dipeptidyl peptidase-4 (DPP-4) inhibitors
- Where
- Canada
- Volunteers
- 419,734 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Coronary Artery Disease, Atrial Fibrillation (AF)
Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management
This study aims to explore the feasibility of using medical large language models to assist in chronic disease management. By setting up experimental and control group interventions and having experts blindly evaluate anonymized…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation (AF), Heart Failure, Stroke
- Trial name
- NCT07740044
- Testing
- Medical large language model
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Ischemic Stroke, Atherosclerosis
Preventive Effects of Ginseng Against Atherosclerosis
This study is a 12-month, double-blind, randomized, placebo-controlled trial. The purpose of this study is to determine whether ginseng is effective in the prevention of atherosclerosis and subsequent ischemic stroke.
- Trial name
- PEGASUS (NCT02796664)
- Testing
- Ginseng
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Dae Chul Suh
Stroke
A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke
This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic…
- Trial name
- NCT02928393
- Testing
- Basmisanil
- Where
- 13 sites in France, Spain
- Volunteers
- 5 people
- Sponsor
- Hoffmann-La Roche
Acute Ischemic Stroke AIS
The STem Cell-derived Extracellular Vesicle Therapy In Acute Ischemic Stroke (STEVIA)
This is a multicenter open-label, single-arm, dose escalation phase I clinical trial to evaluate the safety and tolerability of SNE-101 in patients with acute ischemic stroke
- Trial name
- STEVIA (NCT06995625)
- Testing
- SNE-101
- Where
- 3 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- S&Ebio Co. Ltd.
Stroke, Stroke, Ischemic
Efficacy of REMO Training for Hand Motor Recovery After Stroke
Upper limb motor impairment is one of the most common sequelae after stroke. Indeed, the recovery of upper limb sensory-motor functions remains one of the most important goals in stroke rehabilitation.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Stroke Sequelae
- Trial name
- REMO (NCT05815368)
- Testing
- REMO, Task-Oriented Training
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Post-stroke Cognitive Impairment
Clinical Study of Angong Niuhuang Pill and Acupuncture on PSCI Angong Niuhuang Pill Combined With Supervised Pulse Music Electroacupuncture on Cognitive Impairment After Ischemic Stroke
Post stroke cognitive impairment (PSCI) refers to the attainment of cognitive impairment after the clinical event of stroke A range of syndromes that impede diagnostic criteria.
- Trial name
- NCT05731310
- Testing
- Angong Niuhuang Pill
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke
The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke
The study investigated the clinical efficacy and safety of a 10-day course of therapy with daily intravenous administration of 30mL Cerebrolysin based on a comparison with Placebo in patients with acute ischemic stroke.
- Trial name
- CASTA (NCT00868283)
- Testing
- Cerebrolysin, 0.9% Saline Solution
- Where
- 49 sites in China, Hong Kong and 1 more
- Volunteers
- 1,071 people
- Sponsor
- Ever Neuro Pharma GmbH
Cerebral Stroke
Treatment With AX200 for Acute Ischemic Stroke
The AXIS study is a randomized, double-blind, placebo-controlled, dose-escalating phase IIa trial to investigate treatment with AX200 (granulocyte-colony stimulating factor; G-CSF) for acute ischemic stroke.
- Trial name
- NCT00132470
- Testing
- AX200 (G-CSF)
- Where
- 2 sites in Germany
- Volunteers
- 42 people
- Sponsor
- Axaron Bioscience AG
Ischemic Stroke
Acute Effects of Thai Traditional Massage on Cerebrovascular Reactivity in Ischemic Stroke Patients
The investigators hypothesize that Acute Thai traditional massage will yield beneficial effects on cerebrovascular reactivity in ischemic stroke patients.
- Trial name
- NCT02270294
- Testing
- Thai traditional massage, No massage
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Chulalongkorn University
Acute Ischemic Stroke
Intravenous rhPro-UK Before Stroke Thrombectomy in the Extended Time Window (BRIDGE-PUK EXTEND)
This randomized, double-blind, placebo-controlled phase III clinical trial aims to evaluate the efficacy and safety of intravenous recombinant human Prourokinase (rhPro-UK) in acute ischemic stroke patients with large vessel…
- Trial name
- NCT07389460
- Testing
- Intravenous rhPro-UK, Endovascular thrombectomy
- Where
- 10 sites in China
- Volunteers
- 820 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Progressive Ischemic Stroke
Efficacy Argatroban in Ischemic Stroke With Early Deterioration (EASE)
Acute ischemic stroke (AIS) has the characteristics of high morbidity, high mortality, high disability rate and high recurrence rate. Progressive cerebral infarction (PIS) is a subtype of AIS, accounting for 10% - 40%.
- Trial name
- EASE (NCT04275180)
- Testing
- Argatroban
- Where
- 6 sites in China
- Volunteers
- 628 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Study on the Incremental Predictive Value of Early Resting-State EEG Phenotypes for Functional Prognosis and Risk Stratification in Acute Ischemic Stroke
This is a single-center, prospective, observational cohort study that plans to consecutively enroll 400 patients with acute ischemic stroke from July 2026 to July 2029.
- Trial name
- NCT07741669
- Where
- China
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Stroke
Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke
Rationale: Over 20.000 people suffer an ischemic stroke in the Netherlands each year. Large artery occlusions are easy to identify and can be treated with endovascular clot removal.
- Trial name
- ENCLOSE (NCT04019483)
- Where
- 3 sites in Netherlands
- Volunteers
- 439 people
- Sponsor
- UMC Utrecht
Stroke, Ischemic Attack, Transient
Carotid Occlusion Surgery Study
The purpose of this study is to determine if extracranial-intracranial bypass surgery when added to best medical therapy can reduce the subsequent risk of ipsilateral stroke in high-risk patients with recently symptomatic carotid…
- Conditions
- Stroke, Ischemic Attack, Transient, Cerebral Infarction
- Trial name
- COSS (NCT00029146)
- Testing
- extracranial-intracranial bypass surgery, best medical therapy
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke
The Improve Acute Reperfusion Treatment Quality for Ischemic Stroke Through Spatiotemporal Computing Thecnology in China
This study intends to construct the goal-oriented integrated intervention model through the intelligent bracelet automatic positioning and feedback system based spatiotemporal computing technology (FAST model) to promote the…
- Trial name
- IMPROVE-II (NCT06330051)
- Testing
- The goal-oriented integrated intervention model through the intelligent bracelet automatic positioning and feedback system based spatiotemporal computing technology (FAST model)
- Where
- China
- Volunteers
- 2,219 people
- Sponsor
- Beijing Tiantan Hospital