Clinical trials: Arterial Occlusive Disease
Limb Ischemia, Critical
Role and Outcome of Endovascular Revascularization of Chronic Limb Ischaemia
identify the safety and efficacy of percutaneous transluminal angioplasty in critical limb ischaemia patients with chronic kidney dieases
- Trial name
- NCT05643378
- Volunteers
- 100 people
- Sponsor
- Mahmoud Abdelmohsen Mostafa Osman
Coronary Artery Disease, Inflammatory Response
Efficacy of Dexamethasone to Improve Clinical Outcomes in Coronary Artery Bypass Patients
This is a single-center, double-blind, randomized controlled clinical trial comparing four groups: placebo conventional coronary artery bypass graft (CCABG) group, dexamethasone CCABG group, placebo off-pump coronary artery…
- Trial name
- NCT05487508
- Testing
- Dexamethasone, Normal saline
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Coronary Artery Disease
Inflammation and Coronary Endothelial Function
The investigators are studying whether anti-inflammatory agents can improve abnormal coronary artery function in patients with coronary artery disease (CAD) and abnormal coronary artery endothelial function.
- Trial name
- NCT02366091
- Testing
- Methotrexate, Colchicine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease
Drug-Coated Balloon in Combination With New Generation Drug-Eluting Stent in the Treatment of Long Diffuse Coronary Artery Disease
An observational study to evaluate safety and efficacy of the hybrid approach DES/DCB in the treatment of long diffuse de novo coronary artery disease
- Trial name
- HYPER II (NCT05650450)
- Testing
- DES+DCB
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Coronary Artery Disease
Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease
1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD 2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis) 3.
- Trial name
- EUROCAD (NCT02626806)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, Type 2 Diabetes
Empagliflozin Versus Vildagliptin in CAD Patients With T2DM
We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac…
- Trial name
- NCT06313008
- Testing
- Empagliflozin 10 MG, Vildagliptin 50 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Platelet Aggregation, Platelet Transcriptome
Pharmacogenomics of Antiplatelet Response - I
This clinical trial is examining the role of genetic polymorphism on the effect of clopidogrel (with or without aspirin) on platelet response in persons at high-risk for myocardial infarction or stroke due to family history of…
- Conditions
- Platelet Aggregation, Platelet Transcriptome, Coronary Artery Disease
- Trial name
- PARes-I (NCT01815008)
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease, Heart Diseases
Randomization of Single vs Multiple Arterial Grafts
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a single arterial graft is associated with a…
- Trial name
- ROMA (NCT03217006)
- Testing
- Single arterial graft, Multiple arterial grafting
- Where
- 59 sites in United States, Austria and 15 more
- Volunteers
- 4,300 people
- Sponsor
- Weill Medical College of Cornell University
Intracranial Atherosclerosis
Asymptomatic Intracranial Atherosclerotic Disease in Pakistanis
The incidence of stroke has increased by 100% in the last four decades in developing countries like Pakistan. Intracranial atherosclerotic disease (ICAD) is the most frequent causative subtype of ischemic stroke in the world…
- Trial name
- AICAD (NCT02072876)
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people
- Sponsor
- Aga Khan University
Coronary Artery Disease
CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)
The purpose of this study is to determine the diagnostic performances of iodine contrast medium and resting conditions to predict fractional flow reserve (FFR). Reference FFR will be measured using standard adenosine.
- Trial name
- CONTRAST (NCT02184117)
- Testing
- Adenosine, Contrast Media, Resting conditions
- Where
- 11 sites in United States, Belgium and 7 more
- Volunteers
- 763 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Disease, Optical Coherence Tomography
Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography
The presence of coronary atherosclerotic vulnerable plaque significantly impacts the clinical outcomes of patients diagnosed with coronary artery disease (CAD).
- Trial name
- NCT06520904
- Testing
- PCSK9 inhibitor, Statin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
Coronary Artery Disease
Evaluation of Routine Follow-up Coronary Angiography After Percutaneous Coronary Intervention Trial
The purpose of this study is to evaluate the long term clinical impact of routine follow-up coronary angiography after percutaneous coronary intervention (PCI).
- Trial name
- ReACT (NCT01123291)
- Testing
- follow-up coronary angiography, Clinical follow-up
- Where
- Japan
- Volunteers
- 700 people
- Sponsor
- Takeshi Morimoto
Renal Artery Stenosis
Comparison of Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting
The clinical investigation is a prospective, international, multi-centre, randomized (1:1) trial with follow ups at 2, 6, 12 months and 3 years.
- Trial name
- RADAR (NCT00640406)
- Testing
- Dynamic Renal Stent plus Best Medical Treatment, Best Medical Treatment
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Biotronik AG
Angioplasty, Cardiovascular Disease
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS) China Single-Arm Study
Abbott Vascular (AV) obtained marketing approval for the XIENCE PRIME Everolimus Eluting Coronary Stent System (XIENCE PRIME EECSS) in China from the China Food and Drug Administration (CFDA) on August 10th, 2011.
- Conditions
- Angioplasty, Cardiovascular Disease, Coronary Artery Disease, Coronary Heart Disease
- Trial name
- XP China SAS (NCT01894152)
- Testing
- XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
- Where
- United States
- Volunteers
- 2,002 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Ischaemic Heart Desease
Virtual Reality for Patient Preparation Before Cardiac Catheterization in Oman
Background: Cardiovascular disease is considered one of the most prevalent diseases in recent times, and cardiac catheterization is widely used to diagnose and treat cardiovascular disease.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Desease, Cardiac Catheterization
- Trial name
- NCT07320248
- Testing
- Virtual Reality Education
- Volunteers
- 120 people
- Sponsor
- Sultan Qaboos University
Peripheral Artery Disease
Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia
The aim of this study is to evaluate the potential advantage in terms of late lumen loss reduction of Litos drug-eluting balloon vs standard percutaneous transluminal angioplasty in the treatment of below-the-knee disease in…
- Trial name
- ACOART-BTK (NCT02563535)
- Testing
- DEB, PTA
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- Ospedale San Donato
Coronary Artery Disease
Comparison of Temperature Using Tracheal Thermometer and Pulmonary Artery Catheter in Adult Patients Undergoing CABG
In anesthesia, monitoring of core body temperature is one of important factors. Measurement of temperature using a pulmonary artery catheter is representative one of core temperature measurements.
- Trial name
- TVP (NCT05595616)
- Testing
- Insertion of tracheal thermometer and pulmonary artery catheter
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Pusan National University Yangsan Hospital
Coronary Artery Disease, Acute Myocardial Ischemia
Reduction of Ischemic Myocardium With Ranolazine-Treatment in Patients With Acute Myocardial Ischemia
The aim of the RIMINI-Trial is to examine the effect of Ranolazine on ischemic myocardium in acute myocardial ischemia. A pilot-trial by Venkatamaran et al.
- Trial name
- RIMINI-Pilot (NCT01797484)
- Testing
- Ranolazine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Artery Disease, Anesthesia
Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients with coronary artery disease.
- Trial name
- Strecho-O₂ (NCT04424433)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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