Clinical trials: Arterial Occlusive Diseases
Coronary Artery Disease
Correlation of Cardiac Computed Tomography Angiography Dimensions and Ethnicity in Trinidad
The aim of this study is to compare coronary artery dimensions on Cardiac CT angiography amongst different ethnicities in Trinidad.
- Trial name
- CADET (NCT04774861)
- Where
- Trinidad and Tobago
- Volunteers
- 170 people
- Sponsor
- The University of The West Indies
Peripheral Arterial Disease
POWER: Pulse Intravascular Lithotripsy (Pulse IVL) to Open Vessels With Calcific Walls and Enhance Vascular Compliance and Remodeling
The POWER-PAD-1 Study is a first-in-human evaluation of the safety and performance of the Pulse Peripheral Intravascular Lithotripsy (IVL) Balloon Catheter to enroll up to twenty (20) subjects.
- Trial name
- POWER-PAD-1 (NCT05192473)
- Testing
- Pulse Intravascular Lithotripsy System
- Where
- 3 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 9 people
- Sponsor
- Amplitude Vascular Systems, Inc.
Coronary Artery Disease
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial
Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death.
- Trial name
- POPCORN (NCT05618353)
- Testing
- Colchicine
- Where
- 9 sites in United States
- Volunteers
- 700 people
- Sponsor
- VA Office of Research and Development
Pain, Anxiety
The Effect of Cold Spray Applied Before Local Anaesthesia
Coronary angiography is a reliable and valid method used in the diagnosis of Coronary Artery Disease (CAD). Coronary angiography is defined as the process of obtaining cineangiographic images by administering radio-opaque…
- Conditions
- Pain, Anxiety, Coronary Artery Disease
- Trial name
- EffectofCold (NCT06035237)
- Testing
- Cold Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ozkan Sir
Type 2 Diabetes, Coronary Artery Disease (CAD)
Effect of a Low Advanced Glycation End Products Diet of Patients With Type 2 Diabetes Mellitus
The present study showed that a reduction of approximately 56% in CML consumption promoted a 30% reduction in this blood biomarker.
- Trial name
- NCT07303842
- Testing
- a low-CML diet, Control
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- InCor Heart Institute
Coronary Arteriosclerosis
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
This study will determine whether dietary nitrates and nitrites can produce nitric oxide in the body and dilate blood vessels in patients with coronary artery disease.
- Trial name
- NCT00069654
- Testing
- Forearm blood flow study, Brachial artery reactivity study, Treadmill exercise test
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Effects of Theraband Resistance Training on Muscle Strength in Coronary Artery Diseases
To compare the effects of Theraband Resistance Training with Conventional Resistance Training on muscle strength in coronary artery diseases
- Trial name
- NCT06437756
- Testing
- Theraband resistance training, Conventional Resistance Training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Coronary Artery Disease, Chronic Total Occlusion
CTO-PCI in Heart Failure Patients
The study investigates wheather CTO-PCI improves survival and heart failure related rehospitalization compared to optimal medical therapy (OMT).
- Conditions
- Coronary Artery Disease, Chronic Total Occlusion, Heart Failure
- Trial name
- CTO-HF (NCT05632653)
- Testing
- CTO-PCI
- Volunteers
- 783 people
- Sponsor
- Universitätsmedizin Mannheim
Atherosclerosis
The Effect of Statin Treatment on Trained Innate Immunity
The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various…
- Trial name
- SIMPEL (NCT03354156)
- Testing
- statin treatment
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Hyperlipidemias
Optimal Attained LDL-Cholesterol Levels in Patients Who Achieved ≥50% LDL Reduction After PCI
For the management of low-density lipoprotein-cholesterol (LDL-C), some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in LDL-C levels.
- Trial name
- Lipid-PCI (NCT06338956)
- Testing
- LDL reduction therapy
- Where
- South Korea
- Volunteers
- 135,877 people
- Sponsor
- Samsung Medical Center
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Atherosclerosis
Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration
The purpose of this collaboration is to establish a multi-modality image database including coronary angiograms, optical coherence tomography (OCT), computed tomography angiograms (CTA) and cardiac magnetic resonance imaging…
- Trial name
- NCT04523194
- Testing
- Optical Coherence Tomography (OCT) and Computed Tomography Angiography (CTA)
- Where
- 2 sites in United States, Japan
- Volunteers
- 1,000 people
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Coronary Artery Disease
Prophylactic IABP in High-risk Patients Undergoing CABG
Due to advances and increased practice of interventional therapy for coronary artery disease, the rate of high-risk patients with severe coronary disease and reduced left ventricular function among patients undergoing coronary…
- Trial name
- NCT01950130
- Testing
- Preoperative IABC
- Where
- Germany
- Sponsor
- University of Giessen
Peripheral Arterial Disease
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk
Introduction: Atherosclerotic Peripheral Arterial Disease (PAD) is the leading cause of mortality in the western world. To maintain homeostasis of the vessel wall, vascular cells produce a high level of heat shock proteins (HSP)…
- Trial name
- HSP70 (NCT04743128)
- Testing
- Exercise
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad Popular Autónoma del Estado de Puebla
Coronary Restenosis
Clinical Evaluation of Patients With Everolimus-eluting Stent Xience V® Implanted in the Treatment of Restenosis in Non-coated Metallic Stent (BMS In-stent Restenosis) During a 2 Year Clinical Follow-up Period
Interventional, prospective, non-randomized, non-comparative, open and multicentric study of patients with everolimus-eluting stent " Xience V® " implanted in the treatment of restenosis in non-coated metallic stent (BMS in-stent…
- Trial name
- XERES (NCT00882219)
- Testing
- Xience V®
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Abbott Medical Devices
Dementia
Research on the Early and Prognosis Diagnosis of Vascular Dementia
Around 10% of stroke survivors develop dementia within 3 months after stroke and over 20% more stroke patients have dementia in the subsequent 3 years.
- Trial name
- NCT03152630
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Arterial Occlusive Diseases, Cardiovascular Diseases
Arterial Disease Multifactorial Intervention Trial (ADMIT)
To evaluate, in asymptomatic and symptomatic participants with peripheral arterial disease, the feasibility of recruitment and adherence, efficacy and safety of HDL-C raising along with effective control of LDL-C levels…
- Conditions
- Arterial Occlusive Diseases, Cardiovascular Diseases, Heart Diseases, Vascular Diseases
- Trial name
- NCT00000539
- Testing
- niacin, pravastatin, beta-carotene
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease
Metformin to Reduce Heart Failure After Myocardial Infarction
The investigators will evaluate the effect of metformin therapy during 4 months in non-diabetic patients following ST-elevation myocardial infarction on left ventricular ejection fraction as measured with cardiac magnetic…
- Conditions
- ST Elevation Myocardial Infarction (STEMI), Coronary Artery Disease, Heart Failure, Diabetes
- Trial name
- GIPS-III (NCT01217307)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- University Medical Center Groningen
Coronary Artery Disease
Clopidogrel High Dose Evaluation for the Patient With Coronary Artery Disease in Japan
The purpose of this study is to evaluate the effect of high dose clopidogrel as the antiplatelet therapy on inhibition of platelet aggregation in Japanese patients scheduled for percutaneous coronary intervention due to ischemic…
- Trial name
- CHOICE (NCT01069302)
- Testing
- Clopidogrel
- Where
- Japan
- Volunteers
- 106 people
- Sponsor
- Takeshi Morimoto
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
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