Clinical trials: Arterial Occlusive Diseases
Coronary Artery Disease
Current Treatment Strategy of Patients With Multivessel Disease or Left Main Coronary Artery Disease Indicated for Coronary Artery Bypass Graft Surgery
According to 2011 ACCF/AHA guideline and 2014 ESC/EACTS guideline, CABG surgery was recommended for three-vessel coronary artery disease and left main coronary artery disease in the patients with stable ischemic heart disease as…
- Trial name
- NCT02410993
- Testing
- CABG surgery
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Yonsei University
Peripheral Arterial Disease
DISRUPT PAD III Observational Study
The Disrupt PAD III study was designed as a randomized controlled trial (RCT) with an additional observational registry component.
- Trial name
- PAD III OS (NCT05881421)
- Where
- 30 sites in United States, Germany and 1 more
- Volunteers
- 1,373 people
- Sponsor
- Shockwave Medical, Inc.
Microvascular Angina, Angina Pectoris
Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected.
- Conditions
- Microvascular Angina, Angina Pectoris, Angina, Stable, Non-Obstructive Coronary Atherosclerosis
- Trial name
- CorCMR (NCT04805814)
- Testing
- CMR results disclosed, CMR performed but results not disclosed
- Where
- 3 sites in United Kingdom
- Volunteers
- 280 people
- Sponsor
- NHS National Waiting Times Centre Board
Dyspnea, Coronary Artery Disease
Dyspnea in Stable Patients With Coronary Artery Disease.
Single-centre prospective study to characterize causes of dyspnea in stable patients with coronary artery disease and evaluate the possibility to determine the cause of dyspnea before in-depth examination.
- Trial name
- NCT04408612
- Testing
- Scales for assessment of symptoms
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- National Research Center for Preventive Medicine
Peripheral Artery Disease, Vascular Disease
In-Stent Restenosis Post-Approval Study
The objective of the ISR 14-04 study is to evaluate post-market safety and effectiveness of GORE® VIABAHN® Endoprosthesis for treatment of In-Stent Restenosis of the Superficial Femoral Artery.
- Trial name
- NCT02542267
- Testing
- Gore VIABAHN Endoprosthesis
- Where
- 23 sites in United States, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- W.L.Gore & Associates
Coronary Artery Disease
Clinical Performance of Nano Plus Sirolimus-Eluting Stents in Patients With Coronary Artery Disease
The study aims to evaluate the safety and efficacy of polymer-free sirolimus-eluting coronary stent system (NANO plus) in patients with coronary artery disease .
- Trial name
- NCT02929030
- Testing
- Nano
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease
Myocardial Stress Perfusion Imaging With Dual Source CT
The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan.
- Trial name
- NCT00853671
- Testing
- Adenosine Stress Dual-source CTP
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
The Study of the BX VELOCITY Stent In Patients With De Novo Coronary Artery Lesions.
The main objective of this study is to assess the safety and effectiveness of the sirolimus-coated Bx VELOCITY™ stent in maintaining minimum lumen diameter in de novo native coronary artery lesions as compared to the uncoated Bx…
- Trial name
- E-SIRIUS (NCT00235144)
- Testing
- sirolimus-coated Bx Velocity stent, uncoated Bx Velocity stent
- Where
- 2 sites in Germany
- Volunteers
- 353 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease
SERIES III RUN-IN Clinical Trial: A Comparison of the Supralimus® Stent With the Xience V™ Stent
The objective of Series III Run-In Trial is to compare the performance and efficacy of the Supralimus® sirolimus-eluting stent with the Xience V™ everolimus-eluting stent with respect to in-stent luminal late loss at 9 months as…
- Trial name
- NCT00917163
- Testing
- Supralimus(R) Sirolimus-Eluting Coronary Stent System, Xience V™ Everolimus Eluting Coronary Stent
- Where
- 28 sites in Brazil, India and 1 more
- Volunteers
- 13 people
- Sponsor
- Sahajanand Medical Technologies Limited
Hyperlipidemia, Atherosclerosis
Erythrocyte-bound Apolipoprotein B After Withdrawal of Statin Therapy
Background: preliminary data have shown that erythrocyte-bound apolipoprotein B (ery-apoB) may be protective against atherosclerosis. However, statins may have an effect on ery-apoB.
- Trial name
- EBABAST (NCT01634906)
- Testing
- Temporary discontinuation of statin therapy
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Sint Franciscus Gasthuis
Surgical Wound, Diabetes
EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds
The investigators will test the efficacy of the novel oxygen diffusion dressing allows delivery tissue oxygenation via TransCu O2® Oxygen Delivery System for use in caring for patients with surgically closed wounds.
- Conditions
- Surgical Wound, Diabetes, Amputation Wound, Incision Wound
- Trial name
- NCT03960463
- Testing
- Transcu O2®
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Baylor College of Medicine
Coronary Artery Disease
Evaluation of a XIENCE V® Endoprothesis Used for Coronary Angioplasty, for LPPR (List of Reimbursable Products and Services) Indications in Patients Monitored for 2 Years in France
The objective of this study is to prepare elements of response to the Haute Autorité de Santé (High Health Authority) of France, which is expecting data relating to the routine use of XIENCE V® endoprothesis within the 5 years…
- Trial name
- Far XIENCE V® (NCT00987506)
- Testing
- XIENCE V®
- Where
- 58 sites in France
- Volunteers
- 1,165 people
- Sponsor
- Abbott Medical Devices
Cardiovascular Diseases, Coronary Artery Disease
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
There are 2 arms to this study. Arm 1: Participants undergoing coronary angiography for stable or acute coronary disease presentations and eligible for percutaneous coronary intervention (PCI) will be imaged with OCT-NIRAF at…
- Trial name
- NCT06374498
- Testing
- OCT-NIRAF, LUMISIGHT Injection, OCT-NIRAF following LUMISIGHT Injection
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Stroke, Intracranial Atherosclerosis
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Intracranial atherosclerosis (ICAS) accounts for 10 to 40%, depending on ethnicity, of the 700,000 ischemic strokes in the United States every year.
- Trial name
- NCT03084523
- Testing
- Ferumoxytol Injectable Product
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Peripheral Arterial Disease
Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART)
To demonstrate the efficacy and safety of the mechanical thrombectomy device (JETi 6F and 8F) for treatment of patients with symptomatic peripheral artery disease (PAD) due to acute or acute on chronic occlusions of the femoral…
- Trial name
- JETART (NCT06434779)
- Testing
- JETi 6F and 8F Thrombectomy system
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vascular Science LP GmbH
Peripheral Artery Disease
Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Purpose: The investigators team recently carried out a proof of concept study testing the efficacy of one single 45-minute session of 10 Hz TENS prior to walking, versus placebo.
- Trial name
- TENS-PAD (NCT02678403)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Coronary Artery Disease, Myocardial Ischemia
Efficacy and Safety of ZotaRolimus-Eluting Coronary Stent System In Patients With Long Coronary Artery Disease
This study is to evaluation the efficacy and safety of Zotarolimus-Eluting Stent in patients with long coronary artery disease of 25 mm or longer.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NCT04825886
- Testing
- Zotarolimus-Eluting Stent
- Where
- 20 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Chonnam National University Hospital
Peripheral Arterial Disease
Motivational Interviewing (MI) for African Americans With Peripheral Arterial Disease (PAD)
The investigators are conducting a clinical research trial to determine the role of motivational interviewing (MI) on promoting home-based walking therapy to improve walking ability in African Americans with peripheral arterial…
- Trial name
- NCT01321086
- Testing
- Motivational Interviewing, PACE
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- University of Kansas Medical Center
Peripheral Arterial Disease
Drug Eluting Balloon in Peripheral Intervention for In-Stent Restenosis
The purpose of this study is to evaluate the efficacy of drug-eluting balloon angioplasty followed versus conventional balloon angioplasty in superficial femoral artery and popliteal artery re-stenosis.
- Trial name
- DEBATE-ISR (NCT01558531)
- Testing
- DEB, POBA
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Leonardo Bolognese, MD
Heart Failure, Coronary Artery Disease
123I-mIBG SPECT Imaging
This study is being done with a radioisotope, 123I-mIBG (Adreview), to develop a nuclear diagnostic imaging test for patients with decreased heart function which can be used to predict the progression of the heart disease and…
- Trial name
- NCT02043522
- Testing
- Radioisotope
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
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