Clinical trials: Arterial Occlusive Diseases
Stroke, Acute Ischemic
Early Endovascular Treatment in Isolated Internal Carotid Artery Occlusion
The primary hypothesis being tested in this trial is that acute ischemic stroke with isolated internal carotid artery occlusion will have improved clinical outcomes when given early endovascular treatment compared with that of…
- Trial name
- EVT-iICAO (NCT07016854)
- Testing
- Endovascular treatment, The best medical treatment
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Coronary Artery Disease, Ischemic Heart Disease
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial
This trial will evaluate Orbital Atherectomy compared to conventional balloon angioplasty technique for the treatment of severely calcified lesions prior to implantation of drug-eluting stents (DES).
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
- Trial name
- ECLIPSE (NCT03108456)
- Testing
- Orbital Atherectomy, Balloon
- Where
- 104 sites in United States
- Volunteers
- 2,005 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Ischemic Heart Disease
Coronary and Structural Interventions Ulm - Bioresorbable Vascular Scaffold
To evaluate the safety, performance and efficacy of the bioresorbable vascular scaffold (BVS) system in patients with coronary artery disease
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Stable Angina, Unstable Angina
- Trial name
- CSI-Ulm-BVS (NCT02162056)
- Testing
- use of bioresorbable vascular scaffolds
- Where
- Germany
- Volunteers
- 326 people
- Sponsor
- University of Ulm
Coronary Artery Disease
Smartphone Assessment Prior Radial Artery Harvesting for CABG
Coronary artery bypass graft (CABG) surgery is a procedure where surgeons use blood vessels from elsewhere in the body to go around blockages or narrowings in the heart arteries.
- Trial name
- iRADIAL-CABG (NCT03810729)
- Testing
- Smartphone assessment, Modified Allen's Test
- Where
- Canada
- Volunteers
- 236 people
- Sponsor
- Ottawa Heart Institute Research Corporation
PAOD (Peripheral Arterial Obstructive Disease)
Micro- and Macrovascular Adaptations in Patients With Peripheral Arterial Disease During Supervised Exercise Therapy
Given that previous studies demonstrated the feasibility of the required MRI techniques, we propose to study the macro- and microvascular adaptations in PAOD patients undergoing supervised exercise therapy.
- Trial name
- VAPAV (NCT00675402)
- Testing
- supervised treadmill exercise program
- Where
- Netherlands
- Volunteers
- 117 people
- Sponsor
- Maastricht University Medical Center
Coronary Disease, Verapamil Toxicity
Is Verapamil In TransRadial Interventions OmittabLe?
Background Verapamil is traditionally applied prophylactically in transradial procedures to prevent radial artery spasm. However, verapamil may have side effects and is contraindicated in some clinical settings.
- Trial name
- VITRIOL (NCT01402427)
- Testing
- Verapamil
- Where
- Hungary
- Volunteers
- 591 people
- Sponsor
- State Health Center, Hungary
Carotid Artery Stenosis
Predictive Value for Stroke
Patients with a moderate to severe carotid atherosclerotic plaque are at risk for stroke and this risk increases with increasing degree of stenosis.
- Trial name
- NCT00451529
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Dutch Heart Foundation
Peripheral Arterial Disease (PAD)
Zilver PTX Post-Market Study in Japan
Japanese post market clinical study of the Zilver PTX device.
- Trial name
- NCT02254837
- Testing
- Zilver PTX Drug-Eluting Stent
- Volunteers
- 909 people
- Sponsor
- Cook Group Incorporated
Coronary Artery Disease
OPTIMIZE PCI: Multicenter Randomized Trial of OCT Compared to IVUS and Angiography to Guide Coronary Stent Implantation
The objective of this clinical investigation is to demonstrate the safety and efficacy of an OCT guided strategy for stent implantation
- Trial name
- ILUMIEN III (NCT02471586)
- Testing
- Coronary PCI guided by IVUS, Coronary PCI guided by OCT, Coronary PCI guided by Angiography
- Where
- 29 sites in United States, Belgium and 6 more
- Volunteers
- 450 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
Everolimus- Versus Biolimus-Eluting Stents in All-Comers
This study sought to investigate safety and efficacy of biolimus-eluting stents (BES) with biodegradable polymer as compared with everolimus-eluting stents (EES) with durable polymer through 3 years of follow-up.
- Trial name
- EverBio (NCT01472705)
- Where
- Switzerland
- Volunteers
- 814 people
- Sponsor
- University of Freiburg
Coronary Artery Disease
Breath-hold Cardiac Hybrid SPECT/CCTA
This study aims at combining inspiration breath-hold myocardial perfusion SPECT with coronary CT angiography.
- Trial name
- NCT02469051
- Testing
- Breathhold SPECT-MPI, Standard freebreathing SPECT-MPI, Coronary CT angiography
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Stroke, Intracranial Atherosclerosis
High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke
Intracranial atherosclerotic disease is the most common cause of ischemic stroke in Asia, also in China. Currently, despite vascular recanalization therapy, statins are one of the main drug choices for treating atherosclerotic…
- Conditions
- Stroke, Intracranial Atherosclerosis, High Resolution Magnetic Resonance Imaging
- Trial name
- NCT05897645
- Testing
- Registration
- Where
- China
- Volunteers
- 2,110 people
- Sponsor
- General Hospital of Shenyang Military Region
Coronary Artery Disease, Valvular Heart Disease
Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery
Patients scheduled for cardiac surgery are fragile. Hemodynamic fluctuation might be associated with adverse outcomes. Therefore, it is essential to keep hemodynamics stable during and after the induction period.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Arrythmia
- Trial name
- NCT05323786
- Testing
- The combined topical anesthesia induction group, The routine induction group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Cardiovascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery and Cardiovascular Events
Pathological and clinical studies have consistently demonstrated that abnormalities in thrombosis and hemostasis play a major role in the pathogenesis of atherosclerosis and atherothrombosis.
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Critical Limb Ischemia
- Trial name
- PACE (NCT02106429)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease
STunning After Balloon Occlusion
The aim of this study is to examine in-depth cardiac function and morphology after short-term coronary occlusion by balloon inflation in patients with stable coronary artery disease (CAD) who undergo percutaneous coronary…
- Trial name
- STABO (NCT05023629)
- Testing
- Intracoronary balloon inflation
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Vastra Gotaland Region
Atherosclerotic Cardiovascular Disease
ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab
Primary Objective: To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and…
- Trial name
- NCT01663402
- Testing
- Alirocumab, LMT
- Where
- 1,388 sites in United States, Argentina and 55 more
- Volunteers
- 18,924 people
- Sponsor
- Sanofi
Coronary Heart Disease
Efficacy and Safety of the ACAT Inhibitor CS-505 (Pactimibe) for Reducing the Progression of Coronary Artery Disease
The purpose of this study is to learn if CS-505 is safe and effective for slowing down or possibly reversing the buildup of tissue, cells and fatty deposits (plaque) in the blood vessels of the heart (coronary artery…
- Trial name
- NCT00185042
- Testing
- Pactimibe, CS-505
- Where
- 46 sites in United States
- Volunteers
- 534 people
- Sponsor
- Daiichi Sankyo
Peripheral Arterial Disease
Investigational Study of SWM-831 to Treat Moderate and Severely Calcified Femoropopliteal Arteries
Disrupt PAD Japan is a prospective, multi-center, single-arm study of SWM-831 to treat moderate and severely calcified femoropopliteal arteries, prior to DCB or stenting.
- Trial name
- NCT06938854
- Testing
- Peripheral Intravascular Lithotripsy (IVL)
- Where
- 10 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Shockwave Medical, Inc.
Coronary Artery Disease
Omega-3 Supplementation on Serum Fetuin-A Levels
Background and aims: One of the investigated possible modulators of serum fetuin-A, associated with the risk of developing coronary artery disease (CAD), is omega-3 fatty acids (FAs).
- Trial name
- NCT05661994
- Testing
- Omega-3 fatty acid supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Amasya University
Coronary Disease, Myocardial Infarction
DOCTOR Compare - A Study in the "DOCTOR" Series (Does Optical Coherence Tomography Optimize Revascularization?"
The purpose of this study is to compare optical coherence tomography (OCT) scans performed in the same coronary artery with two different OCT systems (Lunawave and OPTIS) before and after implantation of stents or bioresorbable…
- Conditions
- Coronary Disease, Myocardial Infarction, Atherosclerosis
- Trial name
- NCT02237456
- Testing
- Comparison of OCT scans, Comparison of Intra Vascular Optical Coherence Tomography Systems for Assessment of Coronary Tissue, Stents and Scaffolds - DOCTOR Compare
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Aarhus University Hospital Skejby
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