Clinical trials: Arterial Stiffness
Obesity
Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation.
- Trial name
- NCT04389060
- Testing
- Grape seed extract
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Hypertension, Systolic, Stiffness, Aortic
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke.
- Trial name
- SELECT (NCT04423627)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Pressor Response, Baroreflex Sensitivity
High Resolution Phenotyping in Healthy Humans
Baroreflex sensitivity is integral to blood pressure regulation, and varies among healthy, normotensive individuals. A reduced compensatory ability of baroreflex buffering in patients with carotid denervation results in blood…
- Conditions
- Pressor Response, Baroreflex Sensitivity, Blood Pressure Variability, Heart Rate Variability
- Trial name
- NCT00943774
- Testing
- Physiological maneuvers
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Sedentary Lifestyle
Exercise After Clinically Significant Weight Loss
The Prescribed Exercise to Reduce Recidivism After Weight Loss Pilot (PREVAIL-P) study will evaluate the effect of aerobic exercise training amount on weight maintenance following clinically significant weight loss.
- Conditions
- Obesity, Sedentary Lifestyle, Insulin Resistance
- Trial name
- PREVAIL-P (NCT03685123)
- Testing
- Physical activity recommendations, Weight maintenance recommendations, OPTIFAST weight loss
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Hypertension, Insulin Resistance Syndrome
Cf-PWV and TyG Index Study
This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not…
- Conditions
- Hypertension, Insulin Resistance Syndrome, Arterial Stiffness, Cardiovascular Risk
- Trial name
- RIGID-TyG (NCT07589374)
- Where
- Brazil
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Vascular Aging
Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults
The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines…
- Trial name
- NCT01575288
- Testing
- High-dose trehalose
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Aging, Endothelial Dysfunction
Fisetin to Improve Vascular Function in Older Adults
This is a pilot clinical trial to test the efficacy of intermittent treatment with the flavonoid compound fisetin for improving vascular endothelial function and reducing aortic stiffness in older adults.
- Conditions
- Aging, Endothelial Dysfunction, Arterial Stiffness
- Trial name
- NCT06133634
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Aging, Vascular Stiffness
Acetate and Age-associated Arterial Dysfunction
Cardiovascular diseases are the leading cause of morbidity and mortality and contribute most to healthcare costs in the U.S. Age is the strongest cardiovascular disease risk factor, with >90% of all deaths from cardiovascular…
- Conditions
- Aging, Vascular Stiffness, Vascular Dilation
- Trial name
- NCT05424263
- Testing
- Calcium Acetate Oral Solution, Calcium Carbonate Oral Suspension
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Arterial Stiffness, Blood Pressure
Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women
The goal of this clinical trial is to assess the impact of table grape consumption on gut microbiome, intestinal permeability, systemic inflammation, and vascular function in healthy overweight men and women aged 45-70 years.
- Conditions
- Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation
- Trial name
- CALGRAM (NCT06544954)
- Testing
- Freeze-dried grape powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Sedentary Behavior
Effect of Cocoa Supplementation and Aerobic Exercise on Pressure Parameters
This study evaluates the cocoa supplementation and aerobic exercise on central pressure and arterial stiffness parameters in physically inactive middle-aged individuals. 500mg capsules will be offered to all patients.
- Trial name
- NCT04732754
- Testing
- Aerobic exercise + Theobroma cocoa (AETC), Control Group (CG), Aerobic Exercise (AE)
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Blood Vessel Disease, Muscle Edema
The Influences of Single Chamber vs. Multi-chamber Blood Flow Restriction Cuffs
The purpose of this study is to investigate the use of single (SC) and multi-chamber (MC) blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, and participant perception.
- Trial name
- NCT06276673
- Testing
- Delfi
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Salisbury University
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hypertension, Arterial Stiffness
Effect of High-intensity Interval Training Combined With DASH Diet on Arterial Stiffness in Hypertensive Patients
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide and a major risk factor for morbidity worldwide .
- Trial name
- NCT07188272
- Testing
- DASH diet, High Intensity Interval Training
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Deraya University
Gestational Diabetes
Relationship of Reduced Arterial Stiffness and Hs-CRP With GDM.
Research hypotheses 1. The arterial stiffness in pregnant women with gestational diabetes is reduced compared to healthy pregnant women. 2.
- Trial name
- NCT05479565
- Testing
- venous blood sample for determining the value of highly sensitive C-reactive C protein from serum
- Where
- Bosnia and Herzegovina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Mostar
Healthy
Daily Intake of Cocoa Flavanols and Arterial Stiffness in Humans
A randomized, double-masked and cross-over dietary intervention study to investigate the effects of diet supplementation with cocoa flavanols on arterial stiffness in healthy adult human subjects.
- Trial name
- NCT03587883
- Testing
- Cocoa flavanols I, Control I, Cocoa flavanols II
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Osteoporosis, Cardiovascular Risk Factor
Effects of a 12-week Home-based Yoga on Bone and Cardiovascular Health
While effects of specific exercise interventions on bone and CVD in postmenopausal women have been demonstrated and evaluated, the effects of randomized controlled exercise interventions, particularly in middle-aged premenopausal…
- Trial name
- NCT04353700
- Testing
- Yoga group
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Lowell
Diabetes Mellitus
Changes in Arterial Stiffness and Endothelial Glycocalyx in Patients With Poorly Controlled Diabetes Mellitus Type 1 or Type 2 After Optimization of Antidiabetic Medication.
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT03010956
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Athens
Endothelial Dysfunction, Arterial Stiffness
Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults
This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits.
- Trial name
- NCT06163456
- Testing
- Acute submaximal exercise
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Towson University
Cardiovascular Disease
Dose-dependent Effects of Second-hand Smoke on Vascular Function
The purpose of this study is to determine the vascular effects of brief second-hand smoke exposure on normal healthy individuals.
- Trial name
- NCT01007760
- Testing
- Respirable suspended particles (RSP) PM 2.5 dose of second-hand smoke
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Arterial Stiffness
Augmented Velocity Index of Intra-abdominal, Carotid and Retinal Arteries
Background: Augmented Velocity Index (Avi) is a new Doppler index which can potentially be used to assess arterial stiffness. The Avi of common carotid artery is found to be associated with arterial stiffness and have initial…
- Trial name
- NCT05273905
- Testing
- Ultrasound derived Avi
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong