Clinical trials: Arteriovenous Malformation of Brain, active
Hereditary Hemorrhagic Telangiectasia, HHT
CHORUS - Comprehensive HHT Outcomes Registry of the United States (Formerly OUR HHT Registry)
The goal of this study is to better understand HHT, the symptoms and complications it causes ("outcomes") and how the disease impacts people's lives.
- Conditions
- Hereditary Hemorrhagic Telangiectasia, HHT, Arteriovenous Malformation of Brain
- Trial name
- NCT04150822
- Testing
- Registry and Saliva sample
- Where
- Canada
- Volunteers
- 296 people
- Sponsor
- Unity Health Toronto
Brain Arteriovenous Malformations
In Situ Injection of Anti-angiogenics in Patients With Brain Arteriovenous Malformations Not Eligible for Exclusion Treatment
Brain arteriovenous malformations (bAVMs) are rare aggressive vascular malformations affecting mostly young and healthy adults. The most frequent revealing condition (in almost 50% of cases) is an intra-cerebral hemorrhage, which…
- Trial name
- BLITZ (NCT07075757)
- Testing
- Single in situ intra-arterial injection of bevacizumab
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases
Cerebral Arteriovenous Malformation With Aneurysm: Epidemiology, Clinical Features, and Prognosis
The study is a multicenter, prospective cohort study designed to assess the natural history, clinical safety and efficacy of various treatment strategies in patients with cerebral arteriovenous malformations (AVMs) and…
- Conditions
- Cerebral Arteriovenous Malformation, Intracranial Arterial Diseases, Intra Cerebral Hemorrhage, Intracranial Aneurysm
- Trial name
- NCT07353736
- Where
- China
- Volunteers
- 630 people
- Sponsor
- Duan Chuanzhi
Brain Arteriovenous Malformations
An Exploratory Study to Evaluate the Efficacy and Safety of FCN-159 in Patients With Brain Arteriovenous Malformations
A single-center, open-label, non-randomized controlled exploratory study is conducted in the Xuanwu Hospital Capital Medical University to evaluate the efficacy and safety of FCN-159 in patients with brain arteriovenous…
- Trial name
- NCT06913725
- Testing
- FCN-159
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device
The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble…
- Conditions
- Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale, Pulmonary Arteriovenous Malformation
- Trial name
- SONAS (NCT07414446)
- Testing
- Transcranial Ultrasound Device
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- St. Antonius Hospital
Brain Arteriovenous Malformation
Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Trial name
- MATCH (NCT04572568)
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm, Brain Arterial Disease
Safety, Performance and Usability of BALT Medical Devices: The EVIDENCE Post Marketing Clinical Follow-up Platform
BALT has designed an electronic platform to continue collecting clinical data as part of the post-marketing clinical follow-up of its devices.
- Conditions
- Intracranial Aneurysm, Brain Arterial Disease, Acute Ischemic Stroke, Peripheral Vascular Diseases
- Trial name
- EVIDENCE (NCT04927156)
- Testing
- BALT medical devices
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 10,000 people
- Sponsor
- Balt Extrusion
Unruptured Brain Arteriovenous Malformation
Exploratory Study of Cerebral Perfusion and Metabolic Alterations and Neurocognitive Disorders in Patients With Unruptured Arteriovenous Malformations Before and After Surgical Treatment
The goal of the clinical trial is to describe perfusion and metabolic alterations in different brain regions before and six months after surgical treatment of arteriovenous malformations in adult patients with unruptured…
- Trial name
- APEMMAV-NR (NCT07569887)
- Testing
- 18F-FDG PET imaging, Neuropsychological Assessment
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Montpellier
Arteriovenous Malformation, Bleeding
Clinical Study on Emergency Treatment of Cerebral Arteriovenous Malformation Bleeding
Cerebral arteriovenous malformation (AVM) is the leading cause of brain hemorrhage in young adults, characterized by sudden onset and rapid progression.
- Trial name
- NCT07118631
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm, Arteriovenous Malformations, Cerebral
Patient-specific Planning of Minimally Invasive Brain Interventions Based on Vascular-hemodynamic Mapping
Endovascular procedures for treating brain aneurysms and arteriovenous malformations (AVMs) are becoming increasingly popular due to their less invasive nature and lower risk of complications.
- Trial name
- NCT06588543
- Testing
- Endovascular treatment
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- University Hospital, Ghent
Arterio-venous Fistula, Intracranial Arteriovenous Malformations
PHIL® Embolic System Pediatric IDE
The purpose of this study is to collect information about how the PHIL® Embolic System works in the treatment of intracranial dural arteriovenous fistulas.
- Trial name
- NCT03731000
- Testing
- PHIL® device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Alejandro Berenstein
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Brain Metastases, Adult, Neurocognitive Function
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions
In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing…
- Conditions
- Brain Metastases, Adult, Neurocognitive Function, Cancer, Meningioma of Brain
- Trial name
- IG-SRS (NCT04343157)
- Testing
- Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jona Hattangadi-Gluth
Arteriovenous Malformations
Long Term Follow-up After Embolization of Brain Arteriovenous Malformations
The time-frame and the follow-up elements after embolization of brain arteriovenous malformations are not standardized. Therefore, few reliable follow-up data are available for these patients.
- Trial name
- MAV-endovasc (NCT02879071)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Brain Neoplasms, Cerebral Aneurysm
Clinical Trial for the Validation of AR Based Neuronavigation System
The goal of this clinical trial is to test augmented reality (AR) based neuronavigation system in surgeries for patients of brain neoplasm or cerebral vascular disease.
- Conditions
- Brain Neoplasms, Cerebral Aneurysm, Cerebral Arteriovenous Malformation, Navigation, Spatial
- Trial name
- NCT05776706
- Testing
- AR-based navigation
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Cerebral Arteriovenous Malformations, Ruptured or Unruptured Cerebral Arteriovenous Malformations
Biology of Cerebral Arteriovenous Malformations and Prognosis of Cerebral Arteriovenous Malformations
The cerebral arteriovenous malformations correspond to the formation of an entanglement of morphologically abnormal vessels called nidus, which shunt the blood circulation directly from the arterial circulation to the venous…
- Trial name
- BioMAV (NCT03676868)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral AV Malformation
Efficacy and Safety of Anti-angiogenic Therapy With IV Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations
Brain arteriovenous malformations (AVMs) are responsible for hemorrhagic strokes, particularly in children and young adults. They can also be responsible for chronic neurological disorders: motor or sensory deficits, disturbances…
- Trial name
- BevacizuMAV (NCT06264531)
- Testing
- Bevacizumab
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Brain Arteriovenous Malformations
Language Function Reorganization in Patients With Arteriovenous Malformations
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the…
- Trial name
- NCT07537504
- Testing
- MRI
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Rapid Evacuation and Access of Cerebral Hemorrhage Registry
The goal of this observational study is to quantify the real-world effect of minimally invasive surgery (MIS) in patients with acute spontaneous supratentorial intracerebral hemorrhage.
- Trial name
- REACH (NCT07651631)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Emory University
Vein of Galen Malformations
A Phase II Trial of Fetal Embolization for Vein of Galen Malformation
This is a prospective, single-arm non-randomized interventional study of fetuses to assess the efficacy and safety of fetal embolization of VOGM.
- Trial name
- NCT07483255
- Testing
- Fetal embolization of vein of Galen malformation using Target XL and XXL Detachable Coils
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Darren Orbach