Clinical trials: Artery Disease, Peripheral
Peripheral Arterial Disease
Efficiency, Safety and Portability of Neovasculgen
In 2010, we completed a phase 1 to 2a clinical trial of pCMV-vegf165 in patients with chronic lower limb ischemia (stage 2a to 3 according to Fontaine classification modified by A. V.
- Trial name
- Neovasculgen (NCT03068585)
- Testing
- Neovasculgen (Cambiogeneplasmid)
- Where
- 3 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Artgen Biotech
Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia
Intravascular Ultrasound for Peripheral Artery Disease Revascularization
The purpose of this study is to determine if IVUS use, as compared to angiography alone, prevent major adverse limb events (MALE) or binary restenosis (a greater than 50% re-narrowing of the treated artery) in adult patients who…
- Conditions
- Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia, Intravascular Ultrasound, Major Adverse Limb Events
- Trial name
- CLARITY (NCT06979284)
- Testing
- IVUS-guided strategy
- Where
- 5 sites in Canada
- Volunteers
- 772 people
- Sponsor
- Hamilton Health Sciences Corporation
Peripheral Vascular Diseases
A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)
A 12-Week Efficacy Study in participants with Peripheral Arterial Disease. the primary hypothesis is that MK-0736 7 mg administered once daily for 12 weeks will result in a decrease in lower extremity atherosclerotic plaque…
- Trial name
- NCT00679055
- Testing
- MK-0736
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Diseases, Peripheral Vascular Diseases
L-Arginine in the Treatment of Peripheral Arterial Disease
To assess the effects of L-arginine upon functional status (treadmill exercise testing; quality of life) and limb blood (by mercury strain gauge plethysmography) in peripheral arterial disease.
- Trial name
- NCT00284076
- Testing
- L-arginine
- Sponsor
- Stanford University
Critical Limb Ischemia
Swedish External Support Study
Randomized study to evaluate the effect of adding external support to PTFE-grafts used for bypass to below knee arteries in patients with critical limb ischemia with respect to primary patency, secondary patency, and limb salvage.
- Trial name
- SWEXSUS (NCT01273740)
- Testing
- External support
- Volunteers
- 334 people
- Sponsor
- University Hospital, Linkoeping
Peripheral Vascular Disease
Observing the Role of Inflammation in Peripheral Artery Disease and Its Impact on Heart and Mobility Health: PANACEA-O.
This registry aims to collect detailed information about people in Canada who have Peripheral Artery Disease (PAD) and are receiving care in heart clinics while still able to walk and live in the community.
- Trial name
- PANACEA-O (NCT07500610)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Cardiology Research UBC
Atherosclerosis, Peripheral Arterial Disease
Stella Supera Siberia
Endovascular treatment with stenting is currently used in the treatment of femoro-popliteal lesions. This technique tends to extend to lesions for which the gold standard remains until now the open surgery treatment (lesions TASC…
- Conditions
- Atherosclerosis, Peripheral Arterial Disease, Superficial Femoral Artery Occlusion
- Trial name
- NCT03951727
- Testing
- Endovascular treatment for PAD
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Aortoiliac Occlusive Disease, Endovascular Treatments
Iliac Stent-Grafts in TASC C-D Lesions
This study aims to evaluate the midterm outcomes of patients with advanced aortoiliac artery narrowing (TASC C-D lesions) who were treated with covered iliac stent-grafts instead of open surgery.
- Conditions
- Aortoiliac Occlusive Disease, Endovascular Treatments, Peripheral Arterial Disease(PAD)
- Trial name
- NCT07048925
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Samsun University
Peripheral Artery Disease, Peripheral Vascular Diseases
Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
This single-center, 400-patient, randomized controlled trial assesses the impact of a patient- and provider-facing EPIC Best Practice Advisory (BPA; alert-based computerized decision support tool) to increase guideline-directed…
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Dyslipidemias
- Trial name
- PAD-ALERT (NCT06300450)
- Testing
- Computer Alert
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease
Analysis of Arterial Waveforms and Oxygen Pressure During Supervised Exercise for Peripheral Artery Disease
The goal of this observational study is to assess the evolution of oxygen pressure and arterial waveform during supervised exercise therapy in patients with peripheral arterial disease.
- Trial name
- WAVESUPEX (NCT05818046)
- Testing
- transcutaneous oxygen pressure, Supervised Exercise therapy
- Where
- France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Caen
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Coronary Arterial Disease (CAD), Peripheral Vascular Disease
Colonoscopy and Antiplatelet Therapy Trial
Patients on dual antiplatelet therapy )aspirin plus a P2Y12 inhibitor [clopidogrel, prasugrel, or ticagrelor]) undergoing screening or surveilance colonoscopy are at increased risk for bleeding from the procedure.
- Trial name
- CAPTT (NCT06613191)
- Testing
- Aspirin, P2Y12 inhibitor (clopidogrel, ticagrelor, prasugrel)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ochsner Health System
Critical Limb Ischemia
ACP-01 in Patients With Critical Limb Ischemia
The primary objective of this study is to determine the efficacy and safety of intramuscular injection of ACP-01, comprised of blood-derived autologous ACPs, in subjects with critical limb ischemia who are receiving standard of…
- Trial name
- NCT02551679
- Testing
- ACP-01
- Where
- 19 sites in United States, Canada
- Volunteers
- 67 people
- Sponsor
- Hemostemix
Buerger Disease, Raynaud Syndrome
Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's Disease
The main objective is to assess the feasibility of treatment by injecting botulinum toxin A into the hand or foot of patients with signs of critical ischemia secondary to Buerger's disease.
- Trial name
- BETOX (NCT05698979)
- Testing
- BOTOX INJECTION
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Peripheral Vascular Disease
GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis
This is a prospective, randomized, multi-center study recruiting patients with an in-stent restenosis in the superficial femoral artery. The safety and efficacity of the Viabahn endoprosthesis (W.L.
- Trial name
- RELINE (NCT01108861)
- Testing
- GORE VIABAHN® Endoprosthesis, Plain old balloon angioplasty
- Where
- 6 sites in Belgium, Germany
- Volunteers
- 100 people
- Sponsor
- Flanders Medical Research Program
Peripheral Artery Disease
Alprostadil Liposomes for Injection for Lower Extremity Arteriosclerosis Obliteran
This is a randomized, positive-control, multicenter, multiple-dose, dose-escalation phase II trial
- Trial name
- NCT04197323
- Testing
- Alprostadil liposomes for injection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Foot Ulcers, Arteriosclerosis Obliterans
HELP-Apheresis in Diabetic Ischemic Foot Treatment (H.A.D.I.F)
Diabetic foot (DF) is a common, severe and costly complication of diabetes. DF is underlied by neuropathy, atherosclerosis of distal arteries and infection, which result in tissue ulcers and necrosis.
- Conditions
- Foot Ulcers, Arteriosclerosis Obliterans, Diabetes Mellitus
- Trial name
- HADIF (NCT01518205)
- Testing
- LDL-apheresis
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Universita di Verona
Critical Lower Limb Ischemia
Trans-pedal Access for Endovascular Revascularization in Complex Infra-popliteal Lesions in Critically Ischemic Limb
Background: critical limb ischemia is one of the most challenging cases we face nowadays with high risk for amputation, retrograde trans-pedal angioplasty offers an alternative technique after failure of traditional ante-grade…
- Trial name
- NCT05436405
- Testing
- Trans-pedal access for endovascular revascularization in complex infra-popliteal lesions in critically ischemic limb
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Mansoura University
Chronic Limb Threatening Ischemia
Laser Atherectomy and Sirolimus-eluting Balloon Angioplasty for CLTI
Peripheral arterial disease (PAD) is a widespread pathology affecting over 200 million adults globally and is primarily caused by atherosclerosis.
- Trial name
- LASER-S (NCT07858539)
- Testing
- Laser atherectomy followed by Sirolimus-eluting balloon angioplasty of femoropopliteal or infrapopliteal or both arterial stenosis or occlusions
- Where
- Greece
- Volunteers
- 55 people
- Sponsor
- Attikon Hospital
Of Bypass Graft of the Extremities, Peripheral Arterial Disease
Standard Versus PICO Dressings in Lower-Extremity Bypass Patients
The objective of this study is to compare the effectiveness of standard moist dressings and PICO single-use negative pressure dressings in post-operative lower extremity bypass patients.
- Conditions
- Of Bypass Graft of the Extremities, Peripheral Arterial Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- PICO-LEB (NCT02492854)
- Testing
- PICO Single-Use Negative Pressure Dressings, Sterile Gauze Dressings
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Medical Center
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