Clinical trials: Artery Stenosis
Renal Failure, Renal Artery Stenosis
Renal Blood Flow Measurement With Positron Emission Tomography (PET)
Two investigational chemical tracers, 62Cu-ethylglyoxal bis(thiosemicarbazone) (62Cu-ETS) and 15O-water, will be used in this study to look at how blood moves through the kidneys.
- Trial name
- NCT00714142
- Testing
- 62Cu-ethylglyoxal bis(thiosemicarbazone), 15O-water, Positron Emission Tomography
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jeffrey L. Lacy
Intracranial Atherosclerosis, Stent Stenosis
Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expanding Stent
Intracranial atherosclerotic disease (ICAD) is a high prevalent cause of stroke, especially in Asian population and can be categorized as either symptomatic (resulting in acute ischemic stroke) or asymptomatic.
- Conditions
- Intracranial Atherosclerosis, Stent Stenosis, Ischemic Stroke
- Trial name
- NCT05947994
- Testing
- Intracranial stenting with Credo® stent
- Where
- Vietnam
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Carotid Artery Stenosis
Neuroimaging Correlates of Memory Decline Following Carotid Interventions
Carotid revascularization can significantly reduce the risk of stroke in patients with severe carotid stenosis; however, it has been associated with cognitive decline in 25% of the older adults who undergo the procedure.
- Trial name
- NCT02006095
- Testing
- Magnetic resonance imaging, Neuropsychological testing
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Stanford University
Internal Carotid Artery Stenosis
The Observation About the Effects of Internal Carotid Artery Stenosis on Fundus Vessels and the Changes of Fundus Vessels After Interventional Therapy
The investigators plan to collect 30 participants with internal carotid artery stenosis to observed the relationship between the degree of internal carotid artery stenosis and fundus vessels （and blood flow）density before…
- Trial name
- NCT05260229
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Chest Pain, Acute Coronary Syndrome
The FOVUS-ER Study: Focused Vascular Ultrasound to Risk Stratify Patients With Chest Pain in the ER
Broad Goal: To demonstrate that focused vascular ultrasound (FOVUS) can accurately risk stratify patients with chest pain in the emergency department (ED).
- Conditions
- Chest Pain, Acute Coronary Syndrome, Carotid Artery Plaque
- Trial name
- FOVUS-ER (NCT02947360)
- Testing
- Focused vascular ultrasound of the carotid arteries
- Where
- Canada
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Queen's University
Carotid Artery Stenosis
Optimization Strategy of Carotid Artery Stenosis
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy.
- Trial name
- COAS-CAS (NCT05629000)
- Testing
- Carotid revascularization, MRI-PWI, CTA
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Carotid Artery Stenosis
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
Objective: To evaluate the technical performance of a novel cascaded wave imaging technique compared to plane wave imaging for blood flow imaging in patients with and without carotid artery stenosis.
- Trial name
- CAS-iFLOW (NCT06170580)
- Testing
- Conventional duplex, Ultrasound-based flow imaging using plane wave imaging, Ultrasound-based flow imaging using cascaded wave imaging
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypertension, Retinal Artery Stenosis
Exercise, Arterial Modulation and Nutrition in Youth South Africa Study
The ExAMIN Youth SA study aims to generate new knowledge on the pathophysiology involved in early vascular aging among South African children and to identify early novel biological markers for predicting the subclinical…
- Conditions
- Hypertension, Retinal Artery Stenosis, Childhood Obesity
- Trial name
- ExAMIN-Youth (NCT04056377)
- Where
- South Africa
- Volunteers
- 1,065 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Cerebral Hypoxia, Carotid Stenosis
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their…
- Conditions
- Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
- Trial name
- NCT05652426
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duzce University
Peripheral Vascular Disease
A Multi-center Clinical Trial of the Misago™ Self-Expanding Stent System for Superficial Femoral Artery
OSPREY is a multi-center, single arm, non-randomized, prospective clinical trial. Subjects will undergo a superficial femoral artery (SFA) stent procedure using the Misago™ Peripheral Self Expanding stent once all of the…
- Trial name
- OSPREY (NCT01118117)
- Testing
- Misago™ Self-Expanding Stent System
- Where
- 31 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Terumo Medical Corporation
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Carotid Artery Stenosis, Image
Evaluation of Brain Health and Surgical Efficacy in Patients With Carotid Artery Stenosis
The purpose of this study is to explore the relationship between the recovery of cerebrovascular morphology and cognitive function before and after surgical treatment in patients with carotid artery stenosis and their…
- Trial name
- NCT05848921
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Coronary Artery Stenosis
Effects of Mindfulness Based Therapy on Illness and Depression in Cardiac Rehab Phase-i
A randomize controlled trial will be conducted at Punjab institute of cardiology hospital Lahore, through convenience sampling technique on 48 patients which will be allocated through simple random sampling through sealed opaque…
- Trial name
- NCT05532605
- Testing
- cardiac rehabilitation phase I protocols, Cardiac rehab phase I protocols + Mindfullness base therapy
- Where
- Pakistan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Carotid Stenosis
Alternative Sensory Presentation Formats in Asymptomatic Carotid Stenosis
Background: In a previous study, information verbally presented as relative risk (e.g. "50% less likely") or qualitative risk (e.g.
- Trial name
- NCT01531868
- Testing
- Video
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Coronary Artery Disease, Heart Failure
Stress Echo 2020 - The International Stress Echo Study
Background: Stress echocardiography (SE) has an established role in evidence-based guidelines, but recently the breadth and variety of applications has extended well beyond coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Heart Failure, Hypertrophic Cardiomyopathy, Aortic Valve Disease
- Trial name
- SE2020 (NCT03049995)
- Testing
- Left ventricular contractile reserve SE, B-lines SE, Left ventricular outflow tract gradient SE
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fatebenefratelli Hospital
Williams Syndrome, Supravalvular Aortic Stenosis
Impact of Elastin Mediated Vascular Stiffness on End Organs
Background: People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness.
- Conditions
- Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
- Trial name
- NCT02840448
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerosis
Pilot Study of Ultrasonic Determined Carotid Plaque Composition
Pilot prospective two group observational study to create a model of the carotid plaque composition based on ultrasonic backscattered signals and select clinical data.
- Trial name
- UMP (NCT01879397)
- Testing
- Research Ultrasound Exam
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- D. Geoffrey Vince
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Carotid Artery Plaque, Ischemic Stroke
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke.
- Conditions
- Carotid Artery Plaque, Ischemic Stroke, PET / MR
- Trial name
- NCT07004673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Cerebrovascular Disorders
Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols
The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance…
- Trial name
- NCT00753532
- Where
- Malaysia
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia