Clinical trials: Artery Stenosis
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Coronary Stenosis, Carotid Stenosis
Detection of Coronary Stenosis With Intravenous Microbubbles
To detect coronary artery disease by both coronary and carotid artery imaging and myocardial perfusion imaging using a new low mechanical index real time system.
- Conditions
- Coronary Stenosis, Carotid Stenosis, Myocardial Reperfusion
- Trial name
- NCT00580580
- Testing
- Optison, Definity, PESDA
- Sponsor
- University of Nebraska
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Carotid Stenosis
Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study
This observational study looks at Carotid Stenosis in two groups of subjects using a non-invasive procedure, B-mode ultrasound. One group of subjects has had long-term intensive lipid altering therapy (lowering LDL-C plus raising…
- Trial name
- FATS (NCT00976014)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Washington
Stroke, Acute, Carotid Stenosis
Endovascular Acute Stroke Intervention - Tandem OCclusion Trial
Patients with tandem occlusion or tandem lesion (TL), that is, stroke with an acute intracranial anterior circulation occlusion and an ipsilateral cervical ICA (c-ICA) high-grade stenosis or occlusion, constitute about 15-20% of…
- Conditions
- Stroke, Acute, Carotid Stenosis, Carotid Artery Diseases
- Trial name
- EASI-TOC (NCT04261478)
- Testing
- Carotid artery stenting, Antiplatelet Agents
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Disease
A Trial of DCB vs DES in the Treatment of de Novo Large Diameter Coronary Atherosclerotic Stenosis(LARGE ONE)
For the treatment of primary large-diameter coronary atherosclerosis through percutaneous coronary intervention (PCI), the use of a drug balloon (DCB) is not inferior to the placement of a drug-eluting stent (Firehawk™ family).
- Trial name
- LARGE-ONE (NCT05961787)
- Testing
- SeQuent® Please drug coating balloon(DCB)，Firehawk family drug eluting stent(DES)
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Coronary Artery Disease, Coronary Stenosis
Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment
This investigation is to see if the new Novasight Hybrid imaging catheter can safely and accurately provide two different types of images (IVUS and OCT) of the inside of heart vessels at the same time.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Plaque, Atherosclerotic
- Trial name
- MOUSA (NCT05753085)
- Testing
- Conavi Medical Novasight Hybrid System intervention
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Stenoses, Carotid, Stroke
Anatomical Relationship Between Carotid Artery and Hyoid Bone in Stenotic and Non-stenotic Carotids
Ischaemic stroke is attributable to thromboembolism caused by carotid atherosclerotic disease in 18-25% of patients. Guidelines for prevention of stroke (especially carotid endarterectomy) in patients with carotid atherosclerotic…
- Trial name
- CAROTHYD (NCT05349526)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stroke
Assessment and Quantification of Collateral by ASL MRI
Collateral circulation supports brain tissues to maintain blood perfusion in cerebral ischemic stroke and are of great benefit for a better outcome.
- Trial name
- NCT02479243
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Arterial Diseases, Carotid
Carotid Endarterectomy and Carotid Artery Stenting in Brazil
Cerebrovascular disease is a leading cause of death and the leading cause of serious long-term disability. Carotid artery stenting (CAS) and carotid endarterectomy (CEA) are alternative strategies for stroke prevention in…
- Trial name
- NCT02538276
- Where
- 5 sites in Brazil
- Volunteers
- 500 people
- Sponsor
- University of Sao Paulo
Coronary Artery Stenosis
Cordimax China Post Market Surveillance
Study purpose: This study is a prospective, randomized, controlled multicenter clinical research, which is to assess the effect of Cordimax and Xience V drug-eluting stents as they dealing with all kinds of complex lesions in the…
- Trial name
- NCT03185221
- Testing
- Cordimax, XIENCE V
- Where
- China
- Volunteers
- 3,660 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Carotid Artery Disease, Carotid Stenosis
Carotid Angioplasty and Stenting Versus Endarterectomy in Asymptomatic Subjects Who Are at Standard Risk for Carotid Endarterectomy With Significant Extracranial Carotid Stenotic Disease (ACT I)
The study is being conducted to demonstrate the non-inferiority of carotid artery stenting (CAS) using the Emboshield® Embolic Protection System with the Xact® Carotid Stent System to carotid endarterectomy (CEA) for the…
- Conditions
- Carotid Artery Disease, Carotid Stenosis, Stroke, Atherosclerosis
- Trial name
- ACT I (NCT00106938)
- Testing
- Carotid artery stenting with filter (interventional), Carotid artery endarterectomy (surgical)
- Where
- 62 sites in United States
- Volunteers
- 1,663 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Stenosis
Coronary Laser Atherectomy System for Treatment of Coronary Artery Stenosis (SHINE)
This prospective, multi-center clinical trial evaluates the safety and efficacy of the Coronary Laser Atherectomy System for the pretreatment of coronary artery stenosis.
- Trial name
- SHINE (NCT07697638)
- Testing
- Coronary Laser Atherectomy System, CVX300 Laser System
- Volunteers
- 218 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Ischemic Stroke, Transient Ischemic Attack
Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression
Stroke has become the leading cause of death in China. It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese stroke patients.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Intracranial Artery Stenosis
- Trial name
- NCT03417063
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tsinghua University
Intracranial Artery Stenosis
Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）
GROW-ICAS (Gut microBiota and prOgnostic Outcomes in IntraCranial Arterial Stenosis) is a prospective observational cohort study that enrolls patients with intracranial arterial stenosis to investigate the correlations between…
- Trial name
- NCT07085299
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Carotid Artery Diseases, Neurocognitive Dysfunction
Assessing Neurocognition After Cerebrovascular Intervention
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain.
- Trial name
- NCT03344276
- Testing
- Neurocognitive Assessments, Measurements of inflammatory biomarkers, Carotid Artery Stenting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Carotid Stenosis, Carotid Artery Diseases
Ultrafast Ultrasound Imaging Assesment of Carotid Plaque Neovascularization
Stroke is the second leading cause of death in the Western world and the leading cause of major lifelong disability. About 15% of strokes are secondary to thrombosis or embolization of an unstable atheromatous carotid plaque.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- ULTRA-VASC (NCT04470687)
- Testing
- contrast enhanced ultrafast ultrasound imaging
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease
RFR and FFR for the the Prediction of Post-PCI Results
The aim of this study is to record hemodynamic pullback information using continuous resting full-cycle flow ratio (RFR) and fractional flow reserve (FFR) in patients with diffuse coronary artery disease.
- Trial name
- PICIO (NCT04417634)
- Testing
- RFR, FFR
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Johannes Gutenberg University Mainz
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.
Stents, Coronary Artery Disease
SPIRIT III Clinical Trial of the XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
This study is divided into 5 arms: 1. Randomized Clinical Trial (RCT): Prospective, randomized, active-controlled, single blind, parallel two-arm multi-center clinical trial in the United States (US) comparing XIENCE V®…
- Conditions
- Stents, Coronary Artery Disease, Total Coronary Occlusion, Coronary Artery Restenosis
- Trial name
- NCT00180479
- Testing
- XIENCE V® Everolimus Eluting Coronary Stent, TAXUS® EXPRESS2™ Paclitaxel Eluting Coronary Stent
- Where
- 65 sites in United States
- Volunteers
- 1,002 people
- Sponsor
- Abbott Medical Devices
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