Clinical trials: Artery Stenosis
Carotid Stenosis
Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients
The trial randomise patients with asymptomatic carotid artery narrowing in whom prompt physical intervention is thought to be needed, but there there is still substantial uncertainty shared by patient and doctor about whether…
- Trial name
- ACST-2 (NCT00883402)
- Testing
- CEA, CAS
- Where
- 125 sites in United States, Austria and 30 more
- Volunteers
- 3,638 people
- Sponsor
- University of Oxford
Artery Stenosis
Behavior of the Iliofemoral Segment
Peripheral artery diseases (PAD) are associated with an overall increased risk of mortality and morbidity, as a consequence of fatal or non-fatal vascular events, mainly due to the total or partial occlusion of the affected…
- Trial name
- BEHAVIOR (NCT06113172)
- Testing
- Hip flexion
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Clopidogrel, Poor Metabolism of, Carotid Stenosis
Multicentric Study on Clopidogrel Resistance in DAPT for CAS (MULTI-RESCLOSA)
Spontaneous prospective observational multicentre pharmacological study that aims to evaluate whether, from a statistical point of view, there is a significant difference between the use of Ticagrelor in "non-responders" patients…
- Trial name
- NCT05566301
- Testing
- Clopidogrel, Ticagrelor
- Where
- Italy
- Volunteers
- 1,140 people
- Sponsor
- IRCCS Policlinico S. Donato
Diabetic Foot
Autologous Endothelial Progenitor Cells Treatment of Diabetic Foot
The vascular pathologic basis of diabetic foot include arterial obstruction and micro-circulation defects.The latest technology of arterial reconstruction can only rebuild blood flow of anterior,posterior tibial artery and…
- Trial name
- NCT02474381
- Testing
- EPCs plus PTA, Single PTA
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Severe Symptomatic Aortic Stenosis
Change in Coronary Microcirculation and FFR After TAVI in Patients With Cardiovascular Comorbidities
Change in coronary microcirculation and Fractional Flow Reserve after Transcatheter Aortic Valve Implantation in patients with concomitant coronary artery disease and severe aortic stenosis.
- Trial name
- NCT04663334
- Testing
- inverse myocardial remodeling
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Acute Stroke, Ischemic Stroke
Rescue Intracranial Stenting in Acute Ischemic Stroke
In acute ischemic stroke caused by intracranial large vessel occlusion, rescue intracranial stenting has been recently a treatment option to achieve recanalization in patients with the failure of mechanical thrombectomy.
- Conditions
- Acute Stroke, Ischemic Stroke, Intracranial Atherosclerosis, Stent Stenosis
- Trial name
- RISIS (NCT04986774)
- Testing
- Rescue intracranial stenting
- Where
- Vietnam
- Volunteers
- 85 people
- Sponsor
- Can Tho Stroke International Services Hospital
Coronary Artery Disease, Coronary Artery Stenosis
Vessel Imaging Using Optical Coherence Tomography for Plaque Morphology and Vessel Fractional Flow Reserve
The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between mopphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT)…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Tomography, Optical Coherence, 3D-angio-based FFR
- Trial name
- VISION-FFR (NCT06844942)
- Testing
- vessel Fractional Flow Reserve
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Coronary Artery Disease, Calcified Atheroma
Comparison of Coronary Lithoplasty and Rotablation
This study compares a new method of treating severely calcified coronary lesions, the intracoronary lithoplasty, with the current gold standard, the rotablation.
- Trial name
- NCT04047368
- Testing
- Rotablation, Coronary Lithoplasty
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University of Giessen
ST Elevation Myocardial Infarction, Multi-Vessel Coronary Artery Stenosis
Quantitative Fractional Ratio-guided Revascularization in STEMI Patients With Multi-vessel Disease
About half of patients with ST-segment elevation myocardial infarction (STEMI) have multi-vessel lesions (> 50% diameter stenosis). But how to deal with the non-culprit vessels is still controversial.
- Trial name
- NCT04259853
- Testing
- PCI
- Where
- 15 sites in China
- Volunteers
- 1,016 people
- Sponsor
- Fujian Medical University
Chronic Total Occlusion of Coronary Artery, Coronary Occlusion
ABSORB FIRST is a Registry Designed to Evaluate the Safety and Performance of Absorb Bioresorbable Vascular Scaffold (Absorb BVS) Used in Real-world Patients.
ABSORB FIRST is a prospective, multi-center registry. The objectives of the study are to: Provide ongoing post-market surveillance for documentation of safety, performance and clinical outcomes of the Absorb BVS (Bioresorbable…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Coronary Occlusion, Coronary Artery Disease, Coronary Artery Restenosis
- Trial name
- NCT01759290
- Testing
- Absorb Bioresorbable Vascular Scaffold
- Where
- Belgium
- Volunteers
- 1,800 people
- Sponsor
- Abbott Medical Devices
Coronary Heart Disease
Analysis of Coronary CT Angiography to Identify Patients With Significant Coronary Artery Stenosis
The investigators propose to develop a computational framework involving a novel automatic image segmentation algorithm based on CTA images, an artery model reconstruction algorithm for stenosis detection, and quantification of…
- Trial name
- CTAAnalyzer (NCT02791113)
- Testing
- Fractional Flow Reserve (FFR) Measurement
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- National Heart Centre Singapore
Diabetes Mellitus, Type 2, Major Adverse Cardiac Events
Effect of Patient Management Based on Continuous Continuous Glucose Monitoring on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes and Moderate to Severe Coronary Artery Stenosis
Patients with type 2 diabetes and moderate to severe coronary artery stenosis who were treated at Zhejiang Second Hospital and cooperative hospitals were randomly divided into a patient management group based on continuous…
- Trial name
- NCT06060483
- Testing
- CGM
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Extracranial Atherosclerosis
Images in Extracranial Artery Stenosis
The goals of this trial are: 1. To compare the sensitivity and specificity of various tools including Doppler and magnetic resonance imaging (MRI) for diagnosing vertebral artery stenosis and carotid artery stenosis.
- Trial name
- NCT00173927
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Coronary; Ischemic
Novel Adenosine-independent Index of Coronary Artery Stenosis Severity Resting Flow Reserve
This study will enroll patients who are referred for coronary angiography and require physiological assessment to see if the lesion can be treated as per the local standard of care. Approximately 92 participants will be enrolled.
- Trial name
- RFR (NCT03461705)
- Testing
- Volcano Verrata Pressure Wire, St. Jude Medical (SJM) Aeris Pressure Wire System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Superficial Femoral Artery Stenosis, Iliac Artery Occlusion
Full Metall Jacket Multilevel Segment
Hypothesis: "Total" endovascular revascularization of a multistory lesion of the iliac-femoral-popliteal segment is safer and a better quality of life is achieved in comparison with hybrid intervention.
- Trial name
- FMJSFA (NCT04461496)
- Testing
- Hybrid revascularization, Full metall Jacket
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Aortic Aneurysm, Aortic Aneurysm Abdominal
Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery
This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Valve Stenoses, Aortic, Valve Regurgitation, Mitral
- Trial name
- CLOSURE (NCT06918496)
- Testing
- Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair.
- Where
- 2 sites in Belgium, Poland
- Volunteers
- 60 people
- Sponsor
- Grena Biomed Limited
Symptomatic Intracranial Atherosclerotic Stenosis
Drug- Eluting Stent for Symptomatic Intracranial Arterial Stenosis
This investigation is a prospective, multicenter, randomized controlled, non-inferiority clinical trial, to evaluate the safety and efficacy of the investigational device against alternative models/specifications of the control…
- Trial name
- DESIAS (NCT07197970)
- Testing
- NxiDIME™ Intracranial Drug-Eluting Stent System, NOVA DES Intracranial Drug-Eluting Stent
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Tiantan Hospital
Systematic Intracranial Artery Stenosis
Stenting for Symptomatic Intracranial Artery Stenosis Registry in China
Stenting for systematic Intracranial artery stenosis is challenged recently, especially for safety. This registry is aimed to explore the safety profile during peri-operation period in Stenting procedures for systematic…
- Trial name
- NCT01830413
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis, Asymptomatic Carotid Artery Stenosis
A Study of Evolocumab on Carotid Artery Atherosclerotic Plaque Morphology Prior to Carotid EndArterectomy
This is a multicenter, randomized, open label study with blinded outcome assessment to evaluate the impact of additional/intensive LDL-cholesterol reduction with evolocumab on carotid artery atherosclerotic plaques in higher risk…
- Trial name
- SLICE-CEA (NCT04539223)
- Testing
- Evolocumab
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Aortic Stenosis, Coronary Artery Disease
Optimal Timing of Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention - The TAVI PCI Trial
The primary objective of this study is to compare, in patients with severe aortic stenosis and concomitant coronary artery disease accepted for transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention…
- Conditions
- Aortic Stenosis, Coronary Artery Disease, TAVI, PCI
- Trial name
- TAVI-PCI (NCT04310046)
- Testing
- PCI before TAVI, PCI after TAVI
- Where
- 48 sites in Austria, France and 4 more
- Volunteers
- 986 people
- Sponsor
- University of Zurich
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