Clinical trials: Artery Stenosis
Quadrantectomies, Spinal Fusion
Complementary and Alternative Medicine Interventions in Targeting Pain
This Controlled Randomized Clinical Trial aimed at determining the effectiveness of a modified RR intervention in reducing post-operative pain and psychological symptoms in patients undergoing surgery intervention.
- Conditions
- Quadrantectomies, Spinal Fusion, Carotid Stenosis, Abdominal Aortic Aneurysm
- Trial name
- CAMP (NCT04845334)
- Testing
- RR intervention
- Volunteers
- 128 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Atherosclerosis
Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy
This is a study to compare the effect of VIA-2291 vs. Placebo on various inflammatory biomarkers in patients with carotid stenosis scheduled for elective carotid endarterectomy
- Trial name
- NCT00352417
- Testing
- VIA-2291
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Tallikut Pharmaceuticals, Inc.
Ischemic Heart Disease, Coronary Artery Disease
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)
Despite advancements in medical care, ischemic heart disease (IHD) remains the leading global cause of death. IHD develops through lipid accumulation into the coronary arteries with subsequent formation of larger atherogenic…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Aortic Valve Stenosis, Acute Myocardial Infarction
- Trial name
- IHD-EPITRAN (NCT04533282)
- Testing
- Blood samples., Collection of right atrial appendage tissue sample., Health Survey, Clinical symptom scaling
- Where
- Finland
- Volunteers
- 200 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Carotid Artery Diseases, Carotid Artery Plaque
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected…
- Conditions
- Carotid Artery Diseases, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- NCT04679727
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Carotid Stenosis, Cerebral Hyperperfusion Syndrome
Accuracy of TCD Monitoring in Predicting Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy
Background: Cerebral hyperperfusion syndrome (CHS) is a life threatening complication of carotid endarterectomy (CEA) and the changes of middle cerebral artery velocity are used to predict the occurrence of CHS but the accuracy…
- Conditions
- Carotid Stenosis, Cerebral Hyperperfusion Syndrome, Blood Pressure
- Trial name
- NCT01799070
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Stenosis, Carotid Artery Diseases
The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Study
The goal of this study is to evaluate the incidence of post procedure DW-MRI lesions (relative to baseline) and debris captured in the ENROUTE Transcarotid NPS inline filter during a transcarotid stenting procedure.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Artery Plaque
- Trial name
- DW-MRI OUS (NCT03985774)
- Testing
- Transcarotid revascularization
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 31 people
- Sponsor
- Silk Road Medical
Stenoses, Carotid Artery
Selective Versus Routine Shunting in Carotid Endarterectomy Patients
The project involves prospectively randomizing patients to either routine carotid shunting or selective carotid shunting during Carotid endarterectomy (CEA) under general anesthesia (GA) to see the difference in post-op…
- Trial name
- NCT00967486
- Testing
- Carotid endarterectomy with routine shount, Carotid endarterectomy with selective shunt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Carotid Artery Stenting, Carotid Endarterectomy
Carotid Revascularization Versus Best Medical Treatment for Asymptomatic Carotid Stenosis
This is a multicenter, open, randomized controlled trial to evaluate the efficacy and safety of carotid artery stenting/carotid endarterectomy versus best medical treatment for asymptomatic carotid artery stenosis in Chinese…
- Conditions
- Carotid Artery Stenting, Carotid Endarterectomy, Best Medical Treatment, Carotid Artery Stenosis Asymptomatic
- Trial name
- NCT05623904
- Testing
- Carotid Revascularization, Medical Treatment
- Where
- 11 sites in China
- Volunteers
- 1,056 people
- Sponsor
- Xuanwu Hospital, Beijing
Coronary Artery Disease, Coronary Artery Stenosis
ReZolve2 Clinical Investigation
The RESTORE II clinical trial is intended to assess safety and performance of the ReZolve2 Bioresorbable Coronary Scaffold in native coronary arteries.
- Trial name
- RESTORE II (NCT01845311)
- Testing
- ReZolve2 Scaffold
- Where
- 3 sites in Australia, Brazil and 1 more
- Volunteers
- 89 people
- Sponsor
- REVA Medical, Inc.
Coronary Artery Disease, Chronic Coronary Syndrome
Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients…
- Conditions
- Coronary Artery Disease, Chronic Coronary Syndrome, Acute Coronary Syndrome
- Trial name
- AIM-FFR (NCT07329699)
- Testing
- MPFFR or Invasive FFR
- Where
- 23 sites in South Korea
- Volunteers
- 2,100 people
- Sponsor
- Samsung Medical Center
Common Femoral Artery Stenosis, Calcification; Heart
Shockwave™ vs Surgical Endarterectomy for Calcified Severe Common Femoral Artery Stenosis: Comparison of Efficacy, Safety and Long-Term Outcomes
The investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints.
- Trial name
- Shockify (NCT06829914)
- Testing
- Shockwave Catheter, CFA Endarterectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor Research Institute
Carotid Artery Stenosis
Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of staged carotid angioplasty v.s. routine single-stage carotid artery stenting in Chinese patients with carotid artery stenosis at high hyperperfusion risk in…
- Trial name
- STEP (NCT02224209)
- Testing
- Abbott EPD systems (Accunet/Emboshield), a balloon, stent, a balloon, stent
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Stenosis, Coronary Artery Disease
Prophylactic Intra-coronary Adenosine to Prevent Post Coronary Artery Stenting Myonecrosis
Myocardial damage occurs in up to 40% of cases when sensitive biomarkers are measured after coronary artery stenting. Such events have been associated with poor outcomes both at 30 days and long term.
- Trial name
- NCT00612521
- Testing
- Adenosine
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Diabetes Mellitus, Type 2, Coronary Restenosis
Post-PCI:Cardiac Imaging in Patients With Diabetes to Detect Coronary Artery Blockages Previously Opened by Angioplasty
The purpose of this clinical research study is determine if patients with diabetes that have undergone previous opening of a heart blockage may have a blockage that is not causing any symptoms that may be detected by imaging with…
- Trial name
- NCT00162357
- Testing
- Technetium Tc99m Sestamibi
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 106 people
- Sponsor
- Lantheus Medical Imaging
Coronary Artery Stenosis
DESolve® X-Pand Global Post Market Registry
The X-Pand Registry is intended to facilitate analysis of acute \& long-term safety as well as treatment outcomes with DESolve in patients with CAD.
- Trial name
- X-Pand (NCT02453035)
- Testing
- PTCA - Desolve Scaffold
- Where
- 5 sites in Germany, Netherlands
- Volunteers
- 154 people
- Sponsor
- Elixir Medical Corporation
Carotid Artery Plaque, Arteriosclerosis
Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant
Objectives: Primary: To evaluate the effect of rimonabant 20-mg once daily in comparison with placebo, on the quantitative progression of atherosclerosis as assessed by carotid artery intima-media thickness (CIMT) Secondary: To…
- Conditions
- Carotid Artery Plaque, Arteriosclerosis, Obesity, Metabolic Syndrome X
- Trial name
- AUDITOR (NCT00228176)
- Testing
- Rimonabant
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 661 people
- Sponsor
- Sanofi
Stroke, Stenosis
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic…
- Trial name
- NCT00126139
- Testing
- Abciximab
- Where
- 5 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Peripheral Angioplasty
Computer Prediction of Restenosis Following Peripheral Angioplasty
The purpose of this study is to develop a computer program that might be able to accurately assess the risk of artery re-narrowing following angioplasty or stenting based on computer images.
- Trial name
- NCT01202344
- Testing
- Additional x-ray images
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Dheeraj Rajan
Coronary Stenosis, Acute Coronary Syndrome
Coronary Plaque Geometry and Acute Coronary Syndromes
The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease referred for cardiac computed tomography…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atherosclerosis
- Trial name
- NCT03702764
- Testing
- CCTA
- Where
- Romania
- Volunteers
- 1,000 people
- Sponsor
- Cardio Med Medical Center
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
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