Clinical trials: Artery Stenosis
Healthy, Renovascular Hypertension
Magnetic Resonance Imaging for Evaluating Kidney Function
Renovascular hypertension (RVH) is a potentially curable disease affecting 0.5-5 percent of patients with hypertension. The current diagnostic work-up of RVH involves a complex algorithm which includes doppler ultrasound…
- Trial name
- NCT00006173
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Carotid Stenosis
Lifestyle Modification Programme for Patients With Asymptomatic Carotid Artery Stenosis
This study randomises patients with patients with asymptomatic carotid artery stenosis, to be managed either by providing an intensive 12-week lifestyle modification programme, or standard healthcare.
- Trial name
- NCT03929354
- Testing
- Risk Factors Modification Programme, Standard Care
- Where
- Ireland
- Volunteers
- 208 people
- Sponsor
- Western Vascular Institute, Ireland
Popliteal Artery Stenosis, Atheroma
DAART vs PTA/SUPERA STENTING FOR POPLITEAL ARTERY LESIONS
The purpose of this study was to compare the results of directional atherectomy with antirestenotic therapy (DAART technique) and angioplasty/Supera stenting for the treatment of popliteal atherectomy lesions.
- Trial name
- NCT05617053
- Testing
- DAART, ATP/Supera stenting
- Volunteers
- 143 people
- Sponsor
- Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery
TIA, Carotid Artery Plaque
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
- Conditions
- TIA, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- ELLIPSE (NCT05975554)
- Testing
- Interleukin-2 [IL-2], Standard care - Carotid Endarterectomy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pulmonary Artery Stenosis
A Clinical Trial to Evaluate the Safety and Efficacy of IBS Angel in Patients With Pulmonary Artery Stenosis
This is a prospective, multi-center, single-arm clinical trial to evaluate the safety and efficacy of Iron Bioresorbable Scaffold System (IBS Angel) in patients with pulmonary artery stenosis.
- Trial name
- IRIS (NCT04973540)
- Testing
- Iron Bioresorbable Scaffold System (IBS Angel)
- Where
- 10 sites in China
- Volunteers
- 82 people
- Sponsor
- Biotyx Medical (Shenzhen) Co., Ltd.
Coronary Heart Disease
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM)
Objectives : To compare the efficacy and safety of clopidogrel monotherapy with aspirin monotherapy in patients who received dual or triple antiplatelet therapy for 1 year (± 6 months) after drug-eluting stent implantation for…
- Trial name
- NCT02044250
- Testing
- Clopidogrel, Aspirin
- Where
- South Korea
- Volunteers
- 5,530 people
- Sponsor
- Seoul National University Hospital
Intracranial Arteriosclerosis, Stroke (CVA) or TIA
Evaluating the Safety and Efficacy of the Maurora® DES in ICAS
The purpose of the RCT trial is to evaluate whether implantation of drug-eluting stent (DES) is more efficacious than bare metal stent (BMS) in prevention of in-stent restenosis (ISR) and improvement of outcomes for symptomatic…
- Trial name
- Maurora ICAS (NCT05719883)
- Testing
- Maurora® Sirolimus Eluting Stent System, APOLLO™ Intracranial Stent System
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Coronary Artery Disease
Augmented-Reality CTA Plus Angiography vs Angiography Alone for Guiding PCI in Coronary Lesions - Randomized Study
The purpose of this study is to compare revascularization strategy and its immediate results after augmented-reality computed tomography angiography (CTA) guided vs.
- Trial name
- AR-PCI (NCT03531424)
- Testing
- Angiographic guided PCI, Augmented-Reality CTA guided PCI
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Paul Knaapen
Intracranial Arteriosclerosis, Cognitive Impairment
Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial
This study aims to evaluate whether digital cognitive training and/or PCSK9 inhibitor-enhanced lipid-lowering therapy on top of moderate-intensity statin can improve cognitive function in patients with intracranial…
- Trial name
- NCT07605130
- Testing
- Rosuvastatin, Ezetimibe, Recaticimab
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Peking Union Medical College Hospital
Carotid Stenosis, Ischemic Stroke
Symptomatic Carotid Outcomes Registry
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications.
- Conditions
- Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- SCORE (NCT05300737)
- Testing
- intensive medical therapy
- Where
- 18 sites in United States, Canada
- Volunteers
- 114 people
- Sponsor
- University of Maryland, Baltimore
Renal Artery Stenosis Atherosclerotic, Secondary Hypertension Renal Arterial
Fractional Flow Reserve to Determine Atherosclerosis Renovascular Hypertension Stenting
Although randomized trials have demonstrated there is no benefit of renal-artery stenting in addition to medical therapy for patients with atherosclerosis renal artery stenosis, many patients indeed gained benefit in daily…
- Trial name
- FAIR-Pilot (NCT05732077)
- Testing
- Dopamine, Fractional Flow Reserve, Renal, Renal artery stenting
- Where
- 13 sites in China
- Volunteers
- 100 people
- Sponsor
- Peking University First Hospital
Carotid Artery Stenosis
Neuroimaging Correlates of Memory Decline Following Carotid Interventions
Carotid revascularization can significantly reduce the risk of stroke in patients with severe carotid stenosis; however, it has been associated with cognitive decline in 25% of the older adults who undergo the procedure.
- Trial name
- NCT02006095
- Testing
- Magnetic resonance imaging, Neuropsychological testing
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Stanford University
Visceral Artery Aneurysm, Mesenteric Artery Ischemia
European Multicentre Study of Long-term Results Following Visceral Arteries Revascularization: the E-VisAR Study
Visceral arteries pathologies are a broad-spectrum of conditions with an extremely low incidence, estimated at 9.2% and 6.2% per 100,000 inhabitants for chronic and acute mesenteric ischemia, respectively, and 0.01-0.2% for…
- Conditions
- Visceral Artery Aneurysm, Mesenteric Artery Ischemia, Renal Artery Aneurysm, Renal Artery Stenosis
- Trial name
- E-VisAR (NCT06913530)
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Carotid Stenosis, Cognitive Impairment
Cognitive Improvement After Carotid Stenting in Hyperbaric Oxygen Therapy Trial
The purpose of CARE-HBOT study is to evaluate whether patients with symptomatic severe carotid artery stenosis with cognitive impairment who underwent hyperbaric oxygen therapy plus standard medical treatment after stent…
- Conditions
- Carotid Stenosis, Cognitive Impairment, Hyperbaric Oxygen Therapy, Stent Implantation
- Trial name
- NCT05980195
- Testing
- Hyperbaric oxygen therapy, Standard medical treatment, Risk factor management
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
Cardiovascular Diseases, Fatty Liver
Ultrasound Assessment of Atherosclerotic Plaque Burden and Cardiovascular Risk: A 10-Year Prospective Study
The P-SONAR study is a large, observational, prospective cohort study. The overall aim of the study is to investigate whether plaque burden estimation by 2D ultrasound of the carotid and femoral arteries may enhance…
- Conditions
- Cardiovascular Diseases, Fatty Liver, Atherosclerosis of Femoral Artery, Carotid Artery Plaque
- Trial name
- P-SONAR (NCT06933745)
- Where
- Norway
- Volunteers
- 21,029 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Coronary Artery Stenosis
Anthocyanin Intake on Cardiometabolic Biomarkers
Flavonoids are one of the main groups of polyphenols. Anthocyanins, which are a subgroup of the flavonoid family, are found in a number of fruits and some vegetables.
- Trial name
- NCT05995002
- Testing
- Anthocyanin-rich diet
- Where
- Iran
- Volunteers
- 62 people
- Sponsor
- Shahid Beheshti University
Coronary Artery Disease, Coronary Stenosis
SEA-SIDE: Sirolimus Versus Everolimus-eluting Stent Randomized Assessment in Bifurcated Lesions and Clinical SIgnificance of Residual siDE-branch Stenosis
BACKGROUND: Bifurcated lesions are a challenging subset in percutaneous coronary interventions (PCI). The selection of the type of DES and the technique for stent implantation have not been clarified.
- Trial name
- SEA-SIDE (NCT00697372)
- Testing
- Sirolimus eluting stent, Everolimus eluting stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Catholic University of the Sacred Heart
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Carotid Artery Stenosis
Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation.
The aim of the study is to confirm, whether the MER® stent can be used, without limitations, for the endovascular carotid stenosis treatment in daily clinical practice.
- Trial name
- MER (NCT03133429)
- Testing
- MER
- Where
- 4 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Balton Sp.zo.o.
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