Clinical trials: Artery Stenosis
Peripheral Artery Disease
Safety/Feasibility of Vonapanitase Following Angioplasty for Patients With Peripheral Artery Disease (PAD) Below the Knee (BTK)
The research study is designed to assess the technical feasibility and safety of a perivascular injection of vonapanitase delivered via micro-infusion catheter to the distal popliteal, tibial or peroneal arteries immediately…
- Trial name
- NCT02956993
- Testing
- vonapanitase
- Where
- 9 sites in United States
- Volunteers
- 29 people
- Sponsor
- Proteon Therapeutics
Atherosclerosis
Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy
This is a study to compare the effect of VIA-2291 vs. Placebo on various inflammatory biomarkers in patients with carotid stenosis scheduled for elective carotid endarterectomy
- Trial name
- NCT00352417
- Testing
- VIA-2291
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Tallikut Pharmaceuticals, Inc.
Asymptomatic Carotid Artery Stenosis
Carotid Asymptomatic Stenosis
There is debate on the natural history of asymptomatic severe carotid artery stenosis. Previous studies conducted more than 20 years ago revealed the benefit of carotid endarterectomy compared with medical therapy only on the…
- Trial name
- CARAS (NCT04825080)
- Testing
- duplex ultrasound and computed tomography angiography
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Bologna
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Carotid Atherosclerosis, Carotid Artery Stenting
Long-term Follow-up NIRS-IVUS Imaging of Pre-existing Carotid Stents
The 'Long-term Follow-up Near-infrared Spectroscopy and Intravascular Ultrasound Imaging of Internal Carotid Artery Stenosis Treated With Stenting' trial is an academic research project.
- Conditions
- Carotid Atherosclerosis, Carotid Artery Stenting, Atherosclerotic Plaque, Near Infrared Spectroscopy
- Trial name
- NCT03141580
- Testing
- Near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS)
- Where
- Czechia
- Volunteers
- 52 people
- Sponsor
- University Hospital, Motol
Carotid Stenosis
Ultrasonographic Morphology Assessment of Low-grade Carotid Stenosis
Internal carotid artery (ICA) is intended to supply blood to brain. The carotid bulb located upstream of ICA origin is prone to atherosclerosis.
- Trial name
- QUAMUS (NCT05437991)
- Testing
- Independent morphological quantifications by echo-doppler using ECST method
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Functional Improvement of Coronary Artery Narrowing by Cholesterol Reduction With a PCSK9 Antibody
In a large number of patients who experienced an acute coronary syndrome, multiple narrowings of the coronary arteries are identified.
- Trial name
- FITTER (NCT04141579)
- Testing
- Evolocumab 140 MG/ML [Repatha]
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Plaque, Atherosclerotic
Preventive PCI or Medical Therapy Alone for Vulnerable Atherosclerotic Coronary Plaque
The primary aim of the trial is to determine whether preventive PCI with bioabsorbable vascular scaffolds (BVS) (early period) or everolimus-eluting stents (middle and late period) plus optimal medical therapy (OMT) on…
- Trial name
- PREVENT (NCT02316886)
- Testing
- Coronary intervention, Optimal Medical treatment
- Where
- 18 sites in United States, Japan and 3 more
- Volunteers
- 1,608 people
- Sponsor
- Seung-Jung Park
Inguinal Hernia, Arterial Disease
Inguinal Hernia and Arterial Disease
Inguinal hernias are associated with problems related to the venous system by the linking to extracellular matrix alterations (ECM).
- Trial name
- HEARD (NCT04428138)
- Testing
- In-office vascular visit, Echo duplex scan of arterial system
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Catanzaro
Spinal Stenosis, Intermittent Claudication
Outcome of Surgery for Lumbar Spinal Stenosis - a Comparison of Data From Three National Quality Registries
There is no international consensus on evaluation and surgical treatment of Lumbar Spinal Stenosis (LSS). The indication for operative treatment is relative, and the variation in surgical rates and procedures is significant, both…
- Trial name
- NCT02897947
- Testing
- Surgery for lumbar spinal stenosis in Norway, Surgery for lumbar spinal stenosis in Sweden, Surgery for lumbar spinal stenosis in Denmark
- Volunteers
- 7,500 people
- Sponsor
- St. Olavs Hospital
Pulmonary Artery Stenosis, Tetralogy of Fallot
Retrospective Review of Anesthetic Considerations for Pulmonary Artery Rehabilitation
Pulmonary artery rehabilitation procedure is done frequently in the catheterization suite for patients with pulmonary artery stenosis or small pulmonary arteries following surgical repair for patients with tetralogy of Fallot…
- Conditions
- Pulmonary Artery Stenosis, Tetralogy of Fallot, Pulmonary Atresia
- Trial name
- NCT02586740
- Testing
- Pulmonary artery rehabilitation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Aymen N Naguib
Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD)
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating…
- Conditions
- Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- TAVR-CT (NCT07107568)
- Testing
- Standard Invasive Coronary Angiography, PCD-CT-Guided Diagnostic Strategy
- Where
- 2 sites in Austria
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Coronary Artery Disease, Myocardial Infarction
Genomic Investigation of Cardiovascular Diseases
This proposal puts forward a research plan to initiate a genetic databank, henceforth referred to as The Genebank at Scripps Clinic Registry.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Atrial Fibrillation, Aortic Stenosis
- Trial name
- NCT00722748
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- Scripps Translational Science Institute
Intracranial Arterial Stenosis
Intracranial Arterial Stenosis in Young Patients
The goal of this study is to evaluate the characteristic of intracranial arterial stenosis among young patients.
- Trial name
- ICAS-Young (NCT05844176)
- Testing
- Routine clinical treatment
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Coronary Artery Disease
An Investigation to Evaluate an Over-The-Wire FFR Infusion Microcatheter (HYPEREM™IC) for Measuring Fractional Flow Reserve (FFR)
This is a single-blinded, randomised, crossover investigation comparing the investigational device using intra-coronary (IC) Adenosine infusion to the standard intra-venous (IV) infusion method used for obtaining FFR…
- Trial name
- NCT02527616
- Testing
- FFR Infusion Microcatheter and standard intra-venous (IV) infusion
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Diasolve Ltd
Carotid Artery Stenosis
Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial)
Clinical Trial Summary Trial Title:** CREATE Trial: Safety and Efficacy of IVL for Carotid Calcified Lesions Sponsor:** Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
- Trial name
- CREATE (NCT06936176)
- Testing
- Neurovascular Intravascular Shockwave Catheter
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Angioplasty, Cardiovascular Disease
XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS) China Single-Arm Study
Abbott Vascular (AV) obtained marketing approval for the XIENCE PRIME Everolimus Eluting Coronary Stent System (XIENCE PRIME EECSS) in China from the China Food and Drug Administration (CFDA) on August 10th, 2011.
- Conditions
- Angioplasty, Cardiovascular Disease, Coronary Artery Disease, Coronary Heart Disease
- Trial name
- XP China SAS (NCT01894152)
- Testing
- XIENCE PRIME Everolimus Eluting Coronary Stent System (EECSS)
- Where
- United States
- Volunteers
- 2,002 people
- Sponsor
- Abbott Medical Devices
Carotid Stenosis
Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy
The aim of this study is comparing the effect on cerebral oxygenation by sevoflurane-remifentanil or propofol-remifentanil anesthesia in patient undergoing carotid endarterectomy.
- Trial name
- NCT02609087
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Chonnam National University Hospital
Aortic Regurgitation Disease, Aortic Stenosis Disease
Noninvasive Real-Time Arterial Waveform Monitoring for Cardiovascular Disease Assessment
The goal of this observational study is to learn whether noninvasive real-time arterial waveform monitoring can be used to assess cardiovascular diseases in adults.
- Conditions
- Aortic Regurgitation Disease, Aortic Stenosis Disease, Healthy Subjects
- Trial name
- NCT07350629
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Cancer Hospital
Head and Neck Cancer, Carotid Artery Stenosis
Carotid Ultrasound to Identify Head and Neck Cancer Survivors With High Cardiovascular Risk After Radiation Therapy
The purpose of this research study is to understand how radiation therapy may affect blood vessels in the neck called the carotid arteries.
- Conditions
- Head and Neck Cancer, Carotid Artery Stenosis, Cardiovascular Complication
- Trial name
- NCT05490875
- Testing
- Carotid ultrasound, Blood draw, Survey
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
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