Clinical trials: Artery Stenosis
Intracranial Atherosclerosis
A Single-Arm Trial of Neurovascular Drug-Eluting Balloon Dilatation Catheter Treating Symptomatic Intracranial Atherosclerotic Stenosis
This is a trial designed to test the efficacy and safety of the Neurovascular Drug-Eluting Balloon Dilatation Catheter.
- Trial name
- NCT04949880
- Testing
- Neurovascular Drug-Eluting Balloon Dilatation Catheter
- Where
- 11 sites in China
- Volunteers
- 132 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Carotid Artery Plaque, Ankylosing Spondylitis
Effects of Rosuvastatin on Carotid Artery Plaques in Patients With Inflammatory Joint Disease
Patients with rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) are at greater risk of developing cardiovascular disease.
- Conditions
- Carotid Artery Plaque, Ankylosing Spondylitis, Rheumatoid Arthritis
- Trial name
- RORAAS (NCT01389388)
- Testing
- Rosuvastatin
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- Diakonhjemmet Hospital
STEMI, Coronary Artery Disease
STEMI and Incretins Treatment
ST elevation myocardial infarction (STEMI) patients affected by multivessels coronary artery stenosis, represent a clinical relevant problem. The management and prognosis of these patents are supported by few literature data.
- Conditions
- STEMI, Coronary Artery Disease, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- NCT03312179
- Testing
- PCI and DES stenting, Incretins
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cardiology, Radiology
The Evaluation of the Roles of New Cardiac Imaging in Patients With Chest Pain
This is a prospective, observational study designed to evaluate the role of dynamic computed tomographic perfusion (CTP) and Computed Tomography-Derived Fractional Flow Reserve (CT-FFR) in patients presenting with chest…
- Conditions
- Cardiology, Radiology, Stenoses
- Trial name
- NCT03800862
- Testing
- CT-FFR and CTP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Lancaster General Hospital
Diabetes Mellitus, Coronary Artery Stenosis
The Effect of Pioglitazone on Neointima Volume and Inflammatory Markers
People with diabetes mellitus are more prone to coronary heart disease, stroke, and peripheral vascular disease, and diabetes mellitus has been regarded as an independent risk factor for the progression of coronary artery…
- Trial name
- NCT00494559
- Testing
- Pioglitazone
- Where
- South Korea
- Volunteers
- 240 people
- Sponsor
- Korea University Anam Hospital
Carotid Stenosis
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
- Trial name
- NCT00670202
- Testing
- Fasudil Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease, Peripheral Artery Disease
Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction
Digital Variance Angiography (DVA) is a new tool in medical imaging with proven image quality reserve. The previously observed quality reserve of Digital Variance Angiography (DVA) in lower extremity angiographies, allowed to…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Femoral Artery Stenosis, Femoral Artery Occlusion
- Trial name
- NCT04343196
- Testing
- Diagnostic Angiography (DSA or DVA based on randomization result)
- Where
- Hungary
- Volunteers
- 114 people
- Sponsor
- Kinepict Health Ltd.
Intracranial Arteriosclerosis, Ischemic Preconditioning
Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this registry is to evaluate the safety and efficacy of RIC for patients with symptomatic intracranial atherosclerotic stenosis (sICAS) undergoing endovascular therapy.
- Conditions
- Intracranial Arteriosclerosis, Ischemic Preconditioning, Endovascular Procedures
- Trial name
- NCT05653505
- Testing
- Remote Ischemic Conditioning
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Huanhu Hospital
Carotid Atherosclerosis, Carotid Stenosis
Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral
The aim is to compare the safety of using transfemoral and transradial approach in patient undergoing carotid arteries stenting.
- Conditions
- Carotid Atherosclerosis, Carotid Stenosis, Ischemic Attack, Stroke
- Trial name
- NCT02722720
- Testing
- Transradial carotid artery stenting, Transfemoral carotid artery stenting
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Femoral Artery Stenosis, Femoral Artery Occlusion
Safety and Efficacy Study of FemFlow Drug-Eluting Peripheral Balloon Catheter
A prospective, multi-centre, objective performance criteria clinical trial to evaluate the safety and efficacy of FemFlow Drug-Eluting Peripheral Balloon Catheter manufactured by Lifetech Scientific (Shenzhen) Co., LTD.
- Conditions
- Femoral Artery Stenosis, Femoral Artery Occlusion, Popliteal Arterial Stenosis, Popliteal Artery Occlusion
- Trial name
- NCT03683459
- Testing
- FemFlow Drug-Eluting Peripheral Balloon Catheter
- Where
- 18 sites in China
- Volunteers
- 208 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Peripheral Arterial Disease, Claudication, Intermittent
Arterial Imaging of Inflammation and Resolution After Endovascular Surgery
This study evaluates the local inflammatory and resolution response of patients undergoing peripheral vascular intervention like an angioplasty of the superficial femoral artery (SFA) or popliteal artery, or stenting of the iliac…
- Conditions
- Peripheral Arterial Disease, Claudication, Intermittent, Claudication, PAD
- Trial name
- AIIRES (NCT03590769)
- Testing
- 18F-FDG
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Coronary Artery Disease, Coronary Artery Stenosis
Nationwide Cohort Study of Antiplatelet Agents as Primary Prevention
There is no specific recommendation regarding pharmacologic treatment as primary prevention for patients with intermediate coronary artery stenosis whose revascularization was deferred based on negative fractional flow reserve…
- Trial name
- NHIS (NCT06281041)
- Testing
- Antiplatelet Agents
- Where
- South Korea
- Volunteers
- 4,657 people
- Sponsor
- Samsung Medical Center
Stable Coronary Artery Disease
Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD
Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.
- Trial name
- NCT01209637
- Testing
- exercise training, Intensive exercise training
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Coronary Artery Stenosis
Coronary Artery Stent Evaluation With 320-slice Computed Tomography - The CArS 320 Study
The investigators aim at analyzing the diagnostic accuracy of 320-row CT for coronary stents.
- Trial name
- CARS-320 (NCT00967876)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Charite University, Berlin, Germany
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
LegDeb2 Global Registry for Use of Legflow in Peripheral Arteries
LEGDEB2 is a Global Registry for the Treatment of Superficial Femoral and/or Popliteal or Below-The-Knee or Iliac Artery Lesions Using the Legflow Drug-Eluting Balloon
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Iliac Artery Stenosis, Arterial Occlusive Diseases
- Trial name
- LEGDEB2 (NCT04175197)
- Testing
- Drug Coated Balloon
- Where
- 7 sites in Italy, Mexico
- Volunteers
- 512 people
- Sponsor
- Federico II University
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute
Superficial Femoral Artery Stenosis, Claudication
Contribution of Optical Coherence Tomography in the Endovascular Treatment of Femoral Occlusions
This is a common care study. A study for evaluating the quality of balloon inflation and stent application will be performed in 2D angiography alone in the control group and then by 2D and OCT angiography for the experimental…
- Conditions
- Superficial Femoral Artery Stenosis, Claudication, Ischemic Leg
- Trial name
- TOCAF (NCT04434586)
- Testing
- femoropopliteal revascularization for TASC C or TASC D lesion
- Where
- France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Lille
Coronary Artery Disease
Resting Full-cycle Ratio (RFR)-Guided Revascularization
The purpose of this study is to compare the clinical outcomes of a 2-year follow-up to determine whether RFR-guided coronary intervention is non-inferior to FFR-guided coronary intervention in patients with intermediate coronary…
- Trial name
- NCT06075160
- Testing
- Resting full-cycle ratio (RFR)-guided revascularization, Fractional flow ratio (FFR)-guided revascularization
- Where
- South Korea
- Volunteers
- 1,167 people
- Sponsor
- Sejong General Hospital
Myocardial Ischemia, Coronary Artery Stenosis
ABSORB EXTEND Clinical Investigation
The ABSORB EXTEND trial is to continue the assessment of the safety and performance of the ABSORB Bioresorbable Vascular Scaffold (BVS) System ABSORB BVS is currently in development at Abbott Vascular.
- Conditions
- Myocardial Ischemia, Coronary Artery Stenosis, Coronary Disease, Coronary Artery Disease
- Trial name
- ABSORB EXTEND (NCT01023789)
- Testing
- ABSORB BVS
- Where
- 56 sites in Argentina, Australia and 23 more
- Volunteers
- 812 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, Aortic Valve Stenosis
Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation
The aim of this study is to evaluate the effect of routine FFR-guided complete revascularization with PCI compared to conservative management in patients with concomitant coronary artery disease who are undergoing TAVI.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, TAVI, PCI
- Trial name
- NOTION-3 (NCT03058627)
- Testing
- PCI
- Where
- 12 sites in Denmark, Finland and 2 more
- Volunteers
- 454 people
- Sponsor
- Thomas Engstrom