Clinical trials: Arthritis, Degenerative
Osteoarthritis of the Knee
Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to characterize the local duration of exposure of TCA for 2 doses of FX006 relative to 40 mg of TCA IR in patients with OA of the knee.
- Trial name
- NCT02003365
- Testing
- FX006 10 mg, FX006 40 mg, TCA IR 40 mg
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
Varus Deformity, Valgus Deformity
Prospective Multi-Center Study on Vanguard With E1 Bearing
Evaluate Clinical Performance of Vanguard Knee with E1 Bearing in Korean Patient Population
- Conditions
- Varus Deformity, Valgus Deformity, Posttraumatic Deformity, Osteoarthritis, Knee
- Trial name
- VGRDE1 (NCT02088372)
- Testing
- Vanguard with E1 PS Bearing
- Where
- 4 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis: Joint Replacement Surgery
Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty
Total knee arthroplasty (TKA) is the most common joint replacement surgery and its incidence is expected to increase 673% to 3.48 million procedures annually by 2030.
- Trial name
- NCT03912116
- Testing
- CLARIX FLO, Saline
- Where
- United States
- Sponsor
- BioTissue Holdings, Inc
Osteoarthritis, Arthritis, Rheumatoid
Safety and Efficacy of Mobic Inj. (Meloxicam) for the Patients With OA or RA: Observational Study
The main objective of this PMS study was to monitor and assess the safety of Mobic® intramuscular injection (7.5mg ~ 15mg, q.d.) up to 3 days (in case of need for prolonged treatment, switch to Mobic® capsule therapy was…
- Trial name
- NCT00612885
- Where
- 11 sites in South Korea
- Volunteers
- 425 people
- Sponsor
- Boehringer Ingelheim
Degenerative Arthritis, Knee Osteoarthritis
Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with Knee Osteoarthritis.
- Trial name
- NCT02658344
- Testing
- JOINTSTEM, Saline solution
- Where
- 2 sites in South Korea
- Volunteers
- 24 people
- Sponsor
- R-Bio
Osteoarthritis, Knee
An Efficacy and Safety 6-months Study of SYNOLIS VA 80/160 and SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis
Multicentre, independent assessment study on SYNOLIS VA 80/160 and SYNOLIS VA 40/80 over a period of 24 weeks
- Trial name
- NCT05829798
- Testing
- SYNOLIS VA 80/160, SYNOLIS VA 40/80
- Where
- 3 sites in Poland
- Volunteers
- 82 people
- Sponsor
- Aptissen SA
Degenerative Joint Disease, Osteoarthritis
Post-Market Study of the 3DKnee™ System
The purpose of this study is to evaluate the use and efficacy of the 3DKnee™ System for total knee replacement surgery.
- Conditions
- Degenerative Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT00819481
- Testing
- 3DKnee™ System
- Where
- 8 sites in United States
- Volunteers
- 229 people
- Sponsor
- Encore Medical, L.P.
Pain, Low Back Pain
Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain
The purpose of this study is to determine whether BEMA Buprenorphine is safe in the treatment of chronic pain.
- Conditions
- Pain, Low Back Pain, Osteoarthritis, Neuropathic Pain
- Trial name
- NCT01298765
- Testing
- BEMA Buprenorphine
- Where
- 26 sites in United States
- Volunteers
- 302 people
- Sponsor
- BioDelivery Sciences International
Osteoarthritis of Knee
A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee
A Multi-Centre, Parallel, Double-Blind, Active comparator, Randomised phase III Clinical Trial
- Trial name
- NCT02893098
- Testing
- Humia inj., High hyal Plus inj.
- Where
- South Korea
- Volunteers
- 232 people
- Sponsor
- Huons Co., Ltd.
Knee Osteoarthritis
MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis
The purpose of this study was to evaluate the safety and efficacy of lorecivivint (LOR) injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT03706521
- Testing
- lorecivivint
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Biosplice Therapeutics, Inc.
Arthroplasty, Replacement, Knee
Evaluation of Triathlon - A New Total Knee Prosthesis System - Triathlon PA vs. Triathlon Pressfit
The objective is to investigate the Clinical, Radiographic, Roentgen Stereophotogrammetric behaviour and patient outcome when using the Triathlon total knee prosthesis in a prospective randomized clinical trial.
- Trial name
- TriathlonRSA (NCT03198533)
- Testing
- Triathlon PA, Triathlon Pressfit
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Stryker Orthopaedics
Knee Osteoarthritis
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.
- Trial name
- NCT06741098
- Testing
- NCR100, 0.9% Normal saline
- Volunteers
- 162 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
The present study will aim to evaluate the efficacy of milnacipran in the treatment of pain due to osteoarthritis (OA), that is, to determine whether milnacipran provides superior efficacy to placebo in patients with OA.
- Trial name
- NCT01329406
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Analgesic Solutions
Osteoarthritis Thumb
Post Market Clinical Follow-Up TOUCH® CMC 1
Because severe pain, weakened pinch and grip strength produce functional disabilities, the basal joint of the thumb is the most common site of surgical reconstruction in the upper limb due to OA.
- Trial name
- NCT06546306
- Testing
- TOUCH® CMC 1
- Where
- 6 sites in France
- Volunteers
- 216 people
- Sponsor
- Keri Medical SA
Osteoarthritis, Knee
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
This is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function…
- Trial name
- NCT04440189
- Testing
- GID SVF-2 Device System
- Where
- 9 sites in United States
- Volunteers
- 114 people
- Sponsor
- GID BIO, Inc.
Osteoarthritis of the Knee
Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
This study valuates the safety and efficacy of treatment with 3% Diclofenac Nano-Emulsion Cream versus Placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00484120
- Testing
- 3%-Diclofenac-Nano-Emulsion Cream
- Where
- 4 sites in Israel
- Volunteers
- 123 people
- Sponsor
- Pharmos
Healthy Volunteers, Osteoarthritis
Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain
This is a first-in-human, phase 1, single centre, placebo-controlled, double-blind, single ascending dose study of LEVI-04 in heathy volunteers and osteoarthritis patients (with pain attributed to osteoarthritis of the knee)
- Trial name
- NCT03227796
- Testing
- LEVI-04
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Levicept
Osteoarthritis, Knee, Pain
A Study to Evaluate ONO-4474 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of this phase 2, randomised, double-blind, placebo controlled, parallel group, multicentre study is to investigate the efficacy, safety, tolerability and pharmacokinetics of a compound ONO-4474 in patients with…
- Trial name
- MOTION (NCT02997696)
- Testing
- ONO-4474
- Where
- 47 sites in Denmark, Hungary and 3 more
- Volunteers
- 70 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
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