Clinical trials: Arthritis, Degenerative
Osteoarthritis
Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System
The purpose of this study is to demonstrate that the Uniglide™ Mobile Bearing Unicondylar Knee System (investigational device)is not inferior when compared to the Uniglide™ Fixed Bearing Unicondylar Knee System (control device…
- Trial name
- MBK (NCT00740376)
- Testing
- Uniglide Mobile Bearing Unicondylar Knee System, Uniglide Fixed Bearing Unicondylar Knee System
- Where
- 6 sites in United States
- Volunteers
- 37 people
- Sponsor
- Corin
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Arthritis, Osteoarthritis
A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation
A total knee replacement is the removal of parts of the knee joint, that have become damaged due to osteoarthritis, and replacing these with artificial implants.
- Conditions
- Arthritis, Osteoarthritis, Knee, Joint Diseases
- Trial name
- NCT04976972
- Testing
- NAVIO/CORI Surgical System, Non-robotic conventional instrumentation
- Where
- 10 sites in Ireland, United Kingdom
- Sponsor
- Smith & Nephew Orthopaedics AG
Osteoarthritis, Knee
nCap Pain Relief Patch vs. Placebo
The purpose of this study is to determine whether use of the nCap Medical Nano-Capacitive pain relief patch reduces subject pain as measured by subject pain scores, WOMAC scores (pain, stiffness and physical function), global…
- Trial name
- NCT04753567
- Testing
- nCap pain relief patch
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- nCap Medical
Osteoarthritis
Study Comparing Fit of the iTotal Versus Standard Total Knee Implants
This study compares intraoperative fit of the patient-specific iTotal knee replacement to other standard knee replacement implants
- Trial name
- NCT01861028
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Restor3D
Osteoarthritis
TREAD-20 Extension - Treatment of Knee Pain Due to Osteoarthritis
This extended study will evaluate the efficacy and safety of intra-articular injections of 20mg/2ml dose HYALGAN in patients with pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT00830830
- Testing
- Hyalgan (sodium hyaluronate)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sanofi
Healthy Subjects, Osteoarthritis
Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses in Healthy
The purpose of this study is to evaluate the safety and tolerbility of ascending multiple oral doses of AGG-523 in healthy subjects and in subjects with osteoarthritis.
- Trial name
- NCT00380900
- Testing
- AGG-523
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Knee Osteoarthritis
Evaluation of the Efficacy and Safety of Nise 100 mg in the Management of Osteoarthrosis (Gonarthrosis)
Study is conducted to evaluate safety and efficacy in patients with osteoarthritis
- Trial name
- NISE-2013 (NCT02922712)
- Testing
- NISE
- Volunteers
- 202 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Osteoarthritis, Avascular Necrosis
Aequalis Pyrocarbon IDE; Replacing the Humeral Head in Hemi-Arthroplasty
The purpose of this study is to demonstrate safety and effectiveness of the Aequalis Pyrocarbon Humeral Head in hemiarthroplasty at 24 months.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis
- Trial name
- PYC (NCT02525783)
- Testing
- Aequalis Pyrocarbon Humeral Head
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Knee Osteoarthritis
Prescribed Knee Brace Treatments for Osteoarthritis of the Knee (Knee OA)
The study is a non-controlled retro- and prospective multi center patient registry study. Subjects will be given a study ID number assigned at first brace fitting after consenting to partake.
- Trial name
- NCT04651673
- Testing
- This is a non interventional registry
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Össur Iceland ehf
Osteoarthritis
A 52-Week Study to Assess the Effects of MK0822 on Knee Osteoarthritis (MK-0822-011)
The purpose of this study is to test MK0822 on disease activity in patients with osteoarthritis in the knee. Disease modifying activity of MK0822 will be assessed by measurements of knee cartilage using Magnetic Resonance Imaging…
- Trial name
- NCT00397683
- Testing
- MK0822
- Where
- 16 sites in United States, Chile and 3 more
- Volunteers
- 2 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Low Back Pain
Exposure to Potential Cytochrome P450 Pharmacokinetic Drug-Drug Interactions Among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions
Using a retrospective analysis of a large commercial claims database and a Medicare database, the investigators evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long-term opioid…
- Trial name
- NCT01177254
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- NEMA Research, Inc.
Osteoarthritis Pain
The Single Dose Pharmacokinetics of Two and Proof of Efficacy of One New Etoricoxib Gel Formulation in Participants With Osteoarthritis (MK-0663-168)
Study Part 1 is designed to assess the plasma pharmacokinetics of etoricoxib (ETOR) 4% dimethyl sulfoxide (DMSO) and propylene glycol (PG) formulations, each at 2 different doses, upon single-dose topical administration on the…
- Trial name
- NCT01980940
- Testing
- Etoricoxib 75 mg 4% DMSO Gel, Etoricoxib 75 mg 4% PG Gel, Etoricoxib 150 mg 4% DMSO Gel
- Volunteers
- 70 people
- Sponsor
- Organon and Co
Mild Knee Osteoarthritis (WOMAC 20-32, VAS 2-4)
Efficacy of INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT on Bone and Joint Health
The goal of this clinical trial is to evaluate whether INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT improves joint health in adults aged 40-60 years with mild symptomatic knee osteoarthritis (defined by WOMAC total score 20-32 and…
- Trial name
- NCT07658950
- Testing
- INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Hong Kong Junhuo Biotechnology Co., Limited
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Osteoarthritis, Postoperative Pain
Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement
Pregabalin added to the standard of care with dosing starting preoperatively and continuing for up to 6 weeks post surgery will decrease the intensity of post-operative pain following total knee replacement.
- Trial name
- NCT00442546
- Testing
- pregabalin
- Where
- 27 sites in United States
- Volunteers
- 307 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis of the Knee
Effect of Bioskin Ten-7 vs. Standard Treatment on Patient Reported Outcomes and Cytokine.
The objectives of the study are 1.) to evaluate pain relief following the application of the Bioskin Ten-7 knee brace and 2.) to determine if use of the Bioskin Ten-7 knee brace is more effective at reducing inflammation than…
- Trial name
- Bioskin (NCT02295020)
- Testing
- Standard treatment only, Standard treatment plus Bioskin Ten-7 knee brace
- Volunteers
- 40 people
- Sponsor
- Cropper Medical
Osteoarthritis
Survey of Osteoarthritis Real World Therapies (MK-0663-140)
This was a study to estimate the proportion of participants with osteoarthritis of the knee(s) who were treated with oral or topical analgesics for their symptoms, who did and did not report adequate pain relief at Baseline and…
- Trial name
- SORT (NCT01294696)
- Testing
- Standard of care for treatment of osteoarthritis (OA) of knee(s)
- Volunteers
- 1,261 people
- Sponsor
- Organon and Co
Knee Osteoarthritis
Evaluating the Efficacy and Safety of Intra-articular Injection of HS-20116 in Patients With Knee Osteoarthritis
The purpose of this trial is to evaluate the efficacy and safety of HS-20116 for intra-articular use in patients with symptomatic knee osteoarthritis.
- Trial name
- NCT07047196
- Testing
- HS-20116, Medical Chitosan (for intra-articular injection)
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Osteoarthritis
A Study to Evaluate the Performance of the DePuy Low Contact Stress (LCS®) Complete Anterior-Posterior Glide (APG) Mobile Bearing Knee
The primary objective of this investigation is to determine the survivorship of the LCS Complete AP Glide mobile bearing knee prosthesis at 5 years.
- Trial name
- NCT00733486
- Testing
- L.C.S. APG Knee Anterior Posterior Glide knee
- Where
- 3 sites in South Korea
- Volunteers
- 233 people
- Sponsor
- DePuy International
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.