Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
PhaseⅢOpen-label Study of MRA for Rheumatoid Arthritis(RA)
An open-label, PhaseⅢ study to evaluate the efficacy and safety of MRA in patients with RA
- Trial name
- NCT00380601
- Testing
- MRA(Tocilizumab)
- Where
- 10 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Chugai Pharmaceutical
Rheumatoid Arthritis
A 12 Week Study to Assess Changes in Joint Inflammation Using Ultrasonography in Patients With Rheumatoid Arthritis (RA)
To evaluate the changes in joint inflammation produced by Cimzia over 12 week Treatment period measured by Power/Color Doppler and Gray scale Ultrasound.
- Trial name
- SWIFT (NCT01292265)
- Testing
- Certolizumab Pegol
- Where
- 6 sites in United States
- Volunteers
- 3 people
- Sponsor
- UCB Pharma
Rheumatic Diseases
Disease Activity in RA and SLE Patients and Its Relation to Muscle Performance,Fatigue and Blood Parameters
Assessment of disease activity in Rheumatoid Arthritis and Systemic lupus patients related to muscle performance, fatigue and blood parameters
- Trial name
- NCT03728231
- Testing
- Complete blood count
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis
A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA)
This study will investigate the efficacy of both low and high doses of methotrexate (MTX) in combination with open-label adalimumab (ADA) in patients who have had an inadequate response to high dose of MTX.
- Trial name
- MUSICA (NCT01185288)
- Testing
- Adalimumab, Methotrexate
- Where
- 49 sites in United States, Puerto Rico
- Volunteers
- 309 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rheumatoid Arthritis
Effect of Denosumab in Erosion Healing in RA
To evaluate the effects of denosumab on erosion healing and change in physical function in RA patients.
- Trial name
- NCT03239080
- Testing
- Denosumab
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis
IL-6 as a Biomarker for Personalized Treatment of PR
Several studies have shown the relevance of the IL6 level before treatment or after 6 months, as a predictive biomarker for the persistence of remission.
- Trial name
- REMISIX (NCT04779983)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Adult Onset Rheumatoid Arthritis
A Phase 1b Study of MEDI4920 in Participants With Adult-onset Rheumatoid Arthritis
The purpose of this study is to determine whether VIB4920 (formerly MEDI4920) is safe and well tolerated in participants with adult-onset rheumatoid arthritis (RA).
- Trial name
- NCT02780388
- Testing
- VIB4920
- Where
- 12 sites in United States, Poland
- Volunteers
- 57 people
- Sponsor
- Amgen
Rheumatoid Arthritis (RA)
Use of Acthar in Rheumatoid Arthritis (RA) Related Flares
This is a Rheumatoid Arthritis (RA) study. The purpose of this research study is to determine in RA flare, whether musculoskeletal ultrasound (MSUS) inflammatory scores and/or disease activity scores improve with Acthar treatment.
- Trial name
- NCT02541955
- Testing
- Acthar
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Veena Ranganath, MD, MS
Rheumatoid Arthritis (RA)
A Study Comparing Biologics + Methotrexate With Biologics + Tacrolimus in Patients With Rheumatoid Arthritis (RA)
The purpose of this study is to compare the efficacy of Biologics + Methotrexate with Biologics + Tacrolimus measured by the disease activity score 28 (DAS28) erythrocyte sedimentation rate (ESR) and the American College of…
- Trial name
- NCT03737708
- Testing
- tacrolimus, methotrexate, adalimumab
- Where
- 10 sites in South Korea
- Volunteers
- 21 people
- Sponsor
- Astellas Pharma Korea, Inc.
Arthritis, Rheumatoid
Study to Evaluate SC Route of Administration of Ofatumumab in RA Patients
This study will examine the safety and tolerability, PK and PD of subcutaneously administered GSK1841157 in patients with RA on stable dose Methotrexate.
- Trial name
- NCT00686868
- Testing
- ofatumumab
- Where
- 17 sites in United States, Australia and 7 more
- Volunteers
- 35 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis (RA
Open Label , Randomized, Three Arm Parallel Group Single Dose Comparative Pharmacokinetic , Safety and Immunogenicity Study in Healthy Subjects
The goal of this clinical trial is to learn if Test Product KSHB002 shows equivalence in terms of PK , safety and immunogenicity as compared to reference product ORENCIA used to treat Rheumatoid arthritis .
- Trial name
- abatacept (NCT06929039)
- Testing
- Abatacept
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kashiv BioSciences, LLC
Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA)
Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate whether the live attenuated tetravalent Butantan-Dengue vaccine (Butantan-DV) is safe and capable of inducing an immune response in patients aged 12 to 59 years with autoimmune…
- Conditions
- Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE), Juvenile Systemic Lupus Erythematosus
- Trial name
- BTNDV-ARD (NCT07087912)
- Testing
- Dengue 1,2,3,4 (attenuated) vaccine
- Where
- 2 sites in Brazil
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis
The Effects of Nutritional on Disease Activity and Functional Status in RA
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disease. RA is a chronic inflammatory disease in which many patients cannot achieve remission despite current pharmacological treatments.
- Trial name
- NCT05227885
- Testing
- questionnaire form
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Balikesir University
Pharmacokinetics, Safety
Study to Compare PK & Safety of Advixa With Humira in Healthy, Adult Subject Followed by Efficacy & Safety Study in RA Patients
Adalimumab is a recombinant monoclonal antibody (IgG1 subclass) against human TNF-α (Tumor Necrosis Factor-alpha). It is an immunosuppressive medication predominantly used to treat rheumatoid arthritis autoimmune disease.
- Conditions
- Pharmacokinetics, Safety, Efficacy, Rheumatoid Arthritis
- Trial name
- ACT (NCT05172817)
- Testing
- Advixa (Adalimumab)
- Where
- Bangladesh
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for Developing Science and Health Initiatives, Bangladesh
Rheumatoid Arthritis
A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs
This open-label, single-arm study will evaluate the efficacy and safety of tocilizumab in combination with DMARDs in participants with moderate to severe active rheumatoid arthritis who have an inadequate response to DMARDs.
- Trial name
- NCT00996606
- Testing
- DMARDs, Tocilizumab
- Where
- 11 sites in Italy
- Volunteers
- 58 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis (RA)
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate
The goal of this clinical trial is to evaluate the anti-rheumatic activity and the role of silymarin in attenuating methotrexate toxicity in patients with rheumatoid arthritis.
- Trial name
- NCT06724952
- Testing
- MTX S.C or IM and Silymarin 140 mg tab, MTX S.C or IM
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Rheumatoid Arthritis, Ankylosing Spondylitis
An Observational, Prospective Study to Assess the Efficacy and Safety of Adalloce in Patients With RA and AS
This Study is to Assess the Efficacy and Safety of Adalloce in Patients With Rheumatoid Arthritis and Ankylosing Spondylitis, An Observational, Prospective Study
- Trial name
- NCT05835518
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yuhan Corporation
Rheumatoid Arthritis (RA)
The Effect of Nicorandil on Rheumatoid Arthritis Patients
The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil.
- Trial name
- NCT07730723
- Testing
- Nicorandil Oral Tablet, conventional synthetic antirheumatic drugs (cDMARDs)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Rheumatoid Arthritis
Outcomes of Biological Therapy on Rheumatoid Arthritis
Evaluate effect of biological therapy on activity of RA compared to usual DMARDs
- Trial name
- NCT05267431
- Testing
- Biological Drug
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Rheumatoid Arthritis
Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy Research
This study was intended to assess the efficacy and safety of different Disease-Modifying Antirheumatic Drugs cycle combination regimen using the American College of Rheumatology (ACR) criteria of 20% improvement in symptoms…
- Trial name
- DCCT (NCT01617590)
- Testing
- leflunomide, methotrexate
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanxi Medical University