Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis (RA), Rheumatology
An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis
This clinical study is a multi-center, randomized, double-blind, placebo-controlled, outpatient study comparing the efficacy of combination of dnaJP1 peptide and hydroxychloroquine versus combination of placebo and…
- Trial name
- dnaJP1 (NCT07013110)
- Testing
- dnaJP1
- Where
- Singapore
- Volunteers
- 124 people
- Sponsor
- Prof Salvatore Albani
Arthritis, Rheumatoid
Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients
This study is to evaluate available local data in Iraqi patients with rheumatoid arthritis on Enbrel treatment with regards to the impact of Rheumatoid factor and Anti-cyclic citrullinated peptide using data from the Baghdad…
- Trial name
- NCT04428424
- Testing
- Enbrel
- Where
- Iraq
- Volunteers
- 1,493 people
- Sponsor
- Pfizer
Rheumatoid Arthritis, Rheumatoid Arthritis (RA)
Effect of Roflumilast as Add-On Therapy in Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory disease that causes joint pain, swelling, and reduced physical function. Although standard disease-modifying antirheumatic drugs are effective for many patients, some individuals…
- Trial name
- NCT07632846
- Testing
- Roflumilast 500 Mcg Oral Tablet
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Horus University
Rheumatoid Arthritis
Comparing the Effectiveness of a Treat-to-target (T2T) Disease Management Strategy vs. Routine Care (RC) in Adult Patients With Moderate to Severe Rheumatoid Arthritis (RA) Treated With Subcutaneous Abatacept (Orencia - SC)
This is a 12 month prospective, multicenter, post-marketing, observational study to compare the effectiveness of a treat-to-target (T2T) disease management strategy vs.
- Trial name
- ABC (NCT03274141)
- Testing
- Non-Interventional
- Where
- Canada
- Volunteers
- 281 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA), Remote Patient Monitoring
BloodTrackR Usability and Concordance Study (BUCS): Evaluating a Smart Home-Based Blood Collection Platform for Remote Monitoring in Rheumatoid Arthritis
The BloodTrackR Usability and Concordance Study (BUCS) is evaluating a novel home-based blood collection device and companion mobile application for people with rheumatoid arthritis.
- Trial name
- BUCS (NCT07660029)
- Testing
- BloodTrackR - Home Blood Collection Platform
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Ulster
Rheumatoid Arthritis
A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RA
This study was a Multicenter, Randomized, Blinded Study Comparing the Effect of CRx-102 Plus DMARD Therapy to that of Placebo Plus DMARD Therapy on Serum C Reactive Protein (CRP) and Cytokines in Subjects with Rheumatoid…
- Trial name
- NCT00747214
- Testing
- CRx-102, DMARD Therapy
- Volunteers
- 59 people
- Sponsor
- Zalicus
Rheumatoid Arthritis
The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)
The purpose of this study is to compare the effects of apremilast with a placebo (an inactive substance that looks like apremilast) on you and other people with rheumatoid arthritis.
- Trial name
- NCT01250548
- Testing
- apremilast
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Baylor Research Institute
Arthritis, Rheumatoid
Treat-to-target in RA: Collaboration To Improve adOption and adhereNce
The purpose of this study is to determine if a Learning Collaborative is an effective tool to improve adoption and adherence to a Treat-to-Target (TTT) treatment strategy in U.S.
- Trial name
- TRACTION (NCT02260778)
- Testing
- Learning Collaborative
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis
BG9924 in Combination With Methotrexate for Participants With Active Rheumatoid Arthritis
This Phase 2b study is designed to evaluate the efficacy and safety of BG9924 given subcutaneously (SC) versus placebo in participants with active rheumatoid arthritis (RA) who have previously had an inadequate response to…
- Trial name
- NCT00458861
- Testing
- BG9924
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Biogen
Autoimmune Diseases
Characterization of the Phenotypic Markers of B Cell Lymphocytes in Rheumatoid Arthritis
Rheumatoid Arthritis (RA): RA is a chronic inflammatory autoimmune disease that primarily affects the small joints, eventually leading to bone erosion and an inability to move (1).
- Trial name
- NCT03793270
- Testing
- for patients and healthy donors
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis, Healthy Volunteers
Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy Subjects
The purpose of this study is to investigate the drug interaction between fostamatinib and pioglitazone by comparing the safety, tolerability and plasma concentration of pioglitazone when administered alone and with fostamatinib…
- Conditions
- Rheumatoid Arthritis, Healthy Volunteers, Pharmacokinetics, Pioglitazone
- Trial name
- NCT01309854
- Testing
- fostamatinib, pioglitazone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From "Real World"
Rheumatoid arthritis (RA) is a chronic and disabling disease. tumor necrosis factor-a(TNF-a) inhibitors have demonstrated an outstanding performance in relieving joint inflammation and retarding bone erosion involved in RA.
- Trial name
- NCT02878161
- Testing
- methotrexate(necessary), infliximab, etanercept
- Volunteers
- 240 people
- Sponsor
- Fen Li
RA - Rheumatoid Arthritis
Evaluating the Role of Intra-articular Injections of Platelet Rich Plasma (PRP) in Patients With Rheumatoid Arthritis.
To evaluate the therapeutic effect of 3 local doses of PRP intra-articular injection in patients with RA regarding the improvement of disease activity and quality of life versus placebo.
- Trial name
- NCT04264494
- Testing
- PRP intra articular injection, NACL intra articular injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Dalia Salah Saif
Rheumatoid Arthritis (RA)
A Study of the Safety, Tolerability and Pharmacokinetics of HMPL-523
The primary objective of this study is to assess the safety and tolerability of a single dose of up to 800 mg in Part A (evaluated in planned steps of 5, 20, 50, 100, 200, 300 mg under fasted conditions, followed by 300, 400, 600…
- Trial name
- NCT02105129
- Testing
- HMPL-523
- Where
- Australia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Hutchison Medipharma Limited
Rheumatoid Arthritis
Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid Arthritis
The purpose of the study is to evaluate the clinical efficacy of scheduled versus free reduction of steroid treatment in patients with active RA treated with adalimumab + MTX
- Trial name
- NCT00233558
- Testing
- adalimumab (up to 9 months exposure), methotrexate
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Abbott
Treatment Resistant Carpal Tunnel in RA Patients
ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients
Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection…
- Trial name
- NCT03394131
- Testing
- Hylase, Insulin, saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Rheumatoid Arthritis
Measurement of the Structural Efficacy in Active RA Patients Treated With Sarilumab in Combination With MTX and Naive to Biologics
This is a single site study to determine the structural efficacy of sarilumab when administered to biologic naive patients with active rheumatoid arthritis
- Trial name
- NCT03535402
- Testing
- Sarilumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gaylis, Norman B., M.D.
Rheumatoid Arthritis
Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid Arthritis
The primary purpose of the protocol is to demonstrate the ability of abatacept plus methotrexate to induce remission in patients with very early rheumatoid arthritis after 12 months of treatment and to maintain remission…
- Trial name
- NCT01142726
- Testing
- Abatacept, Methotrexate
- Where
- 73 sites in United States, Australia and 13 more
- Volunteers
- 511 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Multiple Doses Escalation Study of SHR0302 in Rheumatoid Arthritis (RA) Patients
Condition: Rheumatoid Arthritis Intervention: Drug: SHR0302; Drug: SHR0302 placebo comparator Phase: Phase 1 Study Type: Interventional Study Design: Treatment, Parallel Assignment, Double Blind (Subject, Caregiver, Investigator…
- Trial name
- NCT02665910
- Testing
- SHR0302
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Arthritis, Rheumatoid
Long-term Safety and Efficacy of Sirukumab in Participants With RA Completing Studies CNTO136ARA3002 or CNTO136ARA3003
The purpose of this study is to evaluate the long-term safety and efficacy of CNTO 136 (sirukumab) in participants with rheumatoid arthritis (RA) who are unresponsive to treatment with modifying antirheumatic drugs (DMARDs) or…
- Trial name
- SIRROUND-LTE (NCT01856309)
- Testing
- Sirukumab 100 mg, Sirukumab 50 mg
- Where
- 197 sites in United States, Argentina and 27 more
- Volunteers
- 1,820 people
- Sponsor
- Janssen Research & Development, LLC