Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
A Safety and Efficacy Study of Golimumab (CNTO148) in Patients With Active Rheumatoid Arthritis (RA)
The purpose of this study is to evaluate the safety and effectiveness of golimumab in patients with active rheumatoid arthritis despite DMARD (Disease-modifying antirheumatic drugs) therapy.
- Trial name
- NCT00771251
- Testing
- CNTO 148
- Where
- 67 sites in Japan
- Volunteers
- 311 people
- Sponsor
- Janssen Pharmaceutical K.K.
Rheumatoid Arthritis (RA)
Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept
An Agency for Healthcare Research and Quality executive summary indicated that better comparative effectiveness trial designs are needed to determine the relative merits of existing versus new and expensive biologic drug…
- Trial name
- MAZERATI (NCT02353780)
- Testing
- TNF Antagonist (enbrel, humire, remicade, cimzia, symponi), Abatacept, Tocilizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dr. Larry W. Moreland
Rheumatoid Arthritis
A Study of KD6005 in Healthy Participants and Participants With Rheumatoid Arthritis (RA)
This phase 1 study will consist of two parts: Phase 1a is a single-dose study, and will evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary pharmacodynamics (PD) in healthy participants.
- Trial name
- NCT06213259
- Testing
- KD6005
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Kanda Biotechnology Co., Ltd.
Rheumatoid Arthritis
Treatment for Subjects With Active Rheumatoid Arthritis (RA)
The purpose of this study is to assess the safety of etanercept liquid administered once weekly to subjects with RA.
- Trial name
- NCT00110903
- Testing
- Etanercept Liquid
- Sponsor
- Amgen
Rheumatoid Arthritis
Long-term Observational Study to Evaluation the Safety of FURESTEM-RA Inj
Observational Study to evaluate the safety of FURESTEM-RA lnj. in moderate to severe rheumatoid arthritis patients who participated in phase 1 clinical trial of FURESTEM-RA lnj.
- Trial name
- NCT03106259
- Testing
- FURESTEM-RA Inj.
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Kang Stem Biotech Co., Ltd.
Adverse Effect of Glucocorticoids and Synthetic Analogues, Osteoporosis
Improving Bone Health Among Rheumatoid Arthritis (RA) Patients on Chronic Glucocorticoids
This quality improvement project is aimed at improving health care by identifying low cost strategies to get Rheumatoid Arthritis (RA) patients to more effectively communicate with their physicians about osteoporosis prevention…
- Conditions
- Adverse Effect of Glucocorticoids and Synthetic Analogues, Osteoporosis, Rheumatoid Arthritis
- Trial name
- NCT01378689
- Testing
- Storytelling online video
- Where
- United States
- Volunteers
- 4,659 people
- Sponsor
- University of Alabama at Birmingham
Rheumatoid Arthritis
An Global Comparative Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis
This prospective, multi-center, observational study will assess the efficacy and safety of treatment in patients who are treated with a TNF Inhibitor or RoActemra/Actemra (tocilizumab) as the first biologic therapy.
- Trial name
- NCT01543503
- Where
- 154 sites in Argentina, Belgium and 14 more
- Volunteers
- 1,225 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Phase 1b/2 Study of IV Sarilumab in Adult With RA
This is a Phase 1/Phase 2 study with: 5-arms design for Part A; and a single arm for Part B. The purpose of this study is to measure PK parameters and safety with sarilumab intravenous (IV) with or without concomitant oral…
- Trial name
- OPALS (NCT07704580)
- Testing
- Sarilumab, SAR153191 SC, Sarilumab, SAR153191 IV
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sanofi
Rheumatoid Arthritis, Rheumatoid Arthritis RA
Use of Thermography for the Prevention and Diagnosis of Rheumatic Foot
The aim of this observational study is to establish normal thermographic parameters in patients with rheumatoid arthritis, in order to prevent and diagnose rheumatic foot using thermography.
- Conditions
- Rheumatoid Arthritis, Rheumatoid Arthritis RA, Rheumatic Diseases
- Trial name
- TG-AR (NCT06515769)
- Testing
- TERMOGRAPHY
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Seville
Rheumatoid Arthritis (RA
Effect of Siwan Sand Therapy on Pulmonary Functions of Rheumatoid Arthritis Patients
The purpose of this study was to compare between the effects of Siwan sand therapy and physical therapy program on pulmonary function, functional activity, and pain in rheumatoid arthritis patients.
- Trial name
- NCT07287696
- Testing
- sand therapy, physical therapy program
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Ahram Canadian University
Rheumatoid Arthritis
An Observational Study of Tocilizumab (Actemra) in Participants With Moderate to Severe Rheumatoid Arthritis
This observational study evaluates the use and efficacy of intravenous (IV) tocilizumab in routine clinical practice in participants with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01741688
- Testing
- Tocilizumab
- Where
- 4 sites in Peru
- Volunteers
- 16 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Evaluating Kineret® (Anakinra) in Rheumatoid Arthritis (RA) Subjects Using aSelf-Reported Questionnaire
The primary purpose of this study is to assess the ease-of-use of SimpleJectTM compared to pre-filled syringe(s) when using Kineret® in RA subjects.
- Trial name
- NCT00121043
- Testing
- SimpleJectTM, Kineret® (Anakinra)
- Sponsor
- Amgen
Rheumatoid Arthritis
RHYTHM (Formerly Escape II Myocardium)
For aim 1, the proposed studies will be performed in 150 patients with RA and 25 subjects without RA (healthy volunteers) who will function as controls.
- Trial name
- RHYTHM (NCT01548768)
- Testing
- TNF inhibitors, DMARDs
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Columbia University
Rheumatoid Arthritis
A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)
This study will evaluate the efficacy and safety of ocrelizumab, compared with placebo, in combination with methotrexate in patients with active rheumatoid arthritis who are naive to methotrexate.
- Trial name
- FILM (NCT00485589)
- Testing
- Methotrexate, Ocrelizumab
- Volunteers
- 613 people
- Sponsor
- Genentech, Inc.
Rheumatoid Arthritis
A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
The purpose of the study is to compare the effects of methotrexate (MTX) alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab (IFX) on MRI-detected synovitis, bone edema and erosive changes in early…
- Trial name
- NCT00396747
- Testing
- Infliximab, methylprednisolone, methotrexate, Methotrexate, Methotrexate + Methylprednisolone
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Université Catholique de Louvain
Rheumatoid Arthritis (RA)
Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors
The goal is to investigate whether a strategy of attempting to discontinue of MTX or LEF (and restart when necessary) in RA patients treated with an optimal dose (allowed dose or lower, tapered to the maximum, or according to…
- Trial name
- DISCO (NCT07802678)
- Testing
- Strategy to attempt discontinuation of MTX or LEF (and restart when necessary), Continuation of MTX or LEF
- Where
- 4 sites in Netherlands
- Volunteers
- 202 people
- Sponsor
- Sint Maartenskliniek
Rheumatoid Arthritis (RA)
Comparison of Effectiveness and Safety of Tofacitinib Versus Upadacitinib as Add-on to Methotrexate in Rheumatoid Arthritis
The goal of this interventional study is to learn, whether Tofacitinib or upadacitinib is more effective in treating the patients of Rheumatoid Arthritis. It will also learn about the safety of these two agents.
- Trial name
- NCT07636057
- Testing
- JAK inhibitor(tofacitinib/upadacitinib) as advised by the rheumatologist as add on to 25 mg methotrexate
- Volunteers
- 100 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Rheumatoid Arthritis
A Non-Interventional Study of Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab) in Monotherapy
This observational study will evaluate the use and efficacy of RoActemra/Actemra (tocilizumab) in monotherapy in routine clinical practice in participants with rheumatoid arthritis.
- Trial name
- NCT01705730
- Testing
- tocilizumab
- Where
- 17 sites in Belgium
- Volunteers
- 71 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Insomnia
Cognitive Behavioural Therapy for Insomnia on Sleep in Rheumatoid Arthritis.
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory joint disease that attacks peripheral joints and posterior tissues.
- Trial name
- NCT03766100
- Testing
- Cognitive behavioural therapy (CBT-i)
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Bente Appel Esbensen
Rheumatoid Arthritis (RA)
Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis
The objective of this study is to investigate the safety and effectiveness in routine clinical practice and actual clinical setting for all patients with rheumatoid arthritis (RA) treated with peficitinib.
- Trial name
- NCT03971253
- Testing
- Peficitinib
- Where
- 47 sites in Japan
- Volunteers
- 3,000 people
- Sponsor
- Astellas Pharma Inc