Clinical trials: Arthritis, Unspecified
Osteoarthritis, Knee
HKT-500-US12 In Adult Patients With OA Knee Pain
The objective of this study is to characterize the analgesic properties of single dose study of HKT-500 in subjects with pain caused by mild to moderate OA of the knee
- Trial name
- NCT00647231
- Testing
- HKT-500 Topical Patch
- Where
- 29 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Rheumatoid Arthritis
Safety and Preliminary Signs of Efficacy of F8IL10 for Intra-articular Treatment
This multicenter, prospective Phase I study is aimed at testing the safety of F8IL10 via i.a. administration once every 4 weeks over 8 weeks in patients with RA who, despite treatment with stable doses (at least 3 months) of…
- Trial name
- DekaJoint (NCT05622175)
- Testing
- F8IL10
- Sponsor
- Philogen S.p.A.
Rheumatoid Arthritis
A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis (RA)
The main purpose of this study is to evaluate the safety and effectiveness of the study drug known as baricitinib in participants with moderately to severely active rheumatoid arthritis who have had an inadequate response to…
- Trial name
- NCT02265705
- Testing
- Baricitinib
- Where
- 30 sites in Argentina, Brazil and 1 more
- Volunteers
- 290 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis (RA)
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP5094 Following Multiple Intravenous Doses in Subjects With Rheumatoid Arthritis on Methotrexate
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of multiple ascending intravenous doses of ASP5094 in male and female subjects with rheumatoid arthritis (RA) on methotrexate (MTX).
- Trial name
- NCT02698657
- Testing
- ASP5094
- Where
- 13 sites in United States, Poland
- Volunteers
- 30 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Rheumatoid Arthritis
A Pharmacokinetic/Pharmacodynamic Study Comparing PF-05280586 To Rituximab In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To TNF Inhibitors (REFLECTIONS B328-01)
In this study, patients with moderate to severe rheumatoid arthritis who are being treated with methotrexate will receive 2 intravenous treatments with either PF-05280586 or Rituxan (Rituximab) or MabThera (Rituximab).
- Trial name
- REFLECTIONS (NCT01526057)
- Testing
- PF-05280586, MabThera, Rituxan
- Where
- 84 sites in United States, Australia and 8 more
- Volunteers
- 220 people
- Sponsor
- Pfizer
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Knee Osteoarthritis, Hip Osteoarthritis
The Kaia Hip and Knee Pain Intervention for Self-management of the Pain in Patients With Osteoarthritis.
The study intervention provides an innovative way of making exercise training and other recommended lifestyle modifications as accessible as possible for knee and hip OA participants by introducing a home-based exercise training…
- Trial name
- PIVOT (NCT04615377)
- Testing
- Kaia hip and knee pain application, Treatment as usual
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Kaia Health Software
Rheumatoid Arthritis
A Study of the Efficacy and Safety of Tocilizumab in Adults With Rheumatoid Arthritis.
A multi-center, open-label single-arm study to evaluate the efficacy and safety of tocilizumab administered as a single, weekly injection in adults with rheumatoid arthritis.
- Trial name
- NCT01988012
- Testing
- tocilizumab
- Where
- 13 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis, Knee, Pain
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol HCl / Contramid® Tablets to Twice Daily Tramadol HCl (SR) for the Treatment of Osteoarthritis of the Knee
A randomised, multi-centre, double-blind, double dummy, two arm parallel design study to compare the efficacy, safety, and clinical benefit of the test and reference product after treatment for 84 days in patients with…
- Trial name
- NCT00950651
- Testing
- Tramadol HCl Contramid® Once A Day, Tramadol HCl Twice a day
- Volunteers
- 431 people
- Sponsor
- Labopharm Inc.
Osteoarthritis
Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis
Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its…
- Trial name
- NCT00440661
- Testing
- Diacerhein
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- Laboratoires NEGMA
Rheumatoid Arthritis
104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants
To observe the long-term treatment with BG9924 when administered to participants with RA who previously participated in a Biogen Idec Study.
- Trial name
- RESPOND-EXT (NCT00664573)
- Testing
- Baminercept alfa (BG9924)
- Where
- 8 sites in Argentina, Brazil and 6 more
- Volunteers
- 339 people
- Sponsor
- Biogen
Osteoarthritis
Effect Of Celecoxib On Hip Osteoarthritis (OA) Progression
Objectives of the study: Primary: Assess the ability of a continuous treatment of celecoxib 200 mg versus placebo administered once daily (QD) for 24 months in slowing disease progression as assessed radiographically in subjects…
- Trial name
- NCT00163241
- Testing
- celecoxib
- Where
- 130 sites in Canada, France
- Volunteers
- 666 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a TNF-Blocker.
This single arm study will evaluate the efficacy and safety of MabThera in patients with active rheumatoid arthritis whose current treatment with one or more TNF blocker had produced an inadequate response.
- Trial name
- NCT00424502
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- 3 sites in Hungary
- Volunteers
- 20 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to Methotrexate
The purpose of this study is to evaluate the superiority in efficacy of abatacept compared with adalimumab, on background methotrexate, in adults with early, seropositive, and shared epitope-positive rheumatoid arthritis and an…
- Trial name
- NCT04909801
- Testing
- Abatacept, Adalimumab, Methotrexate
- Where
- 75 sites in United States, Argentina and 12 more
- Volunteers
- 338 people
- Sponsor
- Bristol-Myers Squibb
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking Either WHO Step I or Step II Analgesics or no Regular Analgesic
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release in participants suffering from severe chronic pain due to osteoarthritis of the knee who are…
- Trial name
- NCT00983073
- Testing
- Tapentadol
- Where
- 24 sites in France, Germany and 3 more
- Volunteers
- 224 people
- Sponsor
- Grünenthal GmbH
Rheumatoid Arthritis
Study to Evaluate the Safety, PK, PD and Efficacy of AMG 827 in Adults With Rheumatoid Arthritis
This Phase 1b/2a study will evaluate safety, tolerability pharmacokinetics (PK) and pharmacodynamics (PD) of brodalumab when administered in multiple subcutaneous (SC) and intravenous (IV) doses in patients with active rheumatoid…
- Trial name
- NCT00771030
- Testing
- Brodalumab
- Volunteers
- 40 people
- Sponsor
- Amgen
Osteoarthritis
A Study Of The Effects Of CB2 Compound Of GW842166 In Patients With Osteoarthritis
This is a double-blind, two-period, placebo controlled cross-over Phase IIa study. This study is to use CB2 compound of GW842166 in patients with osteoarthritis.
- Trial name
- NCT00479427
- Testing
- GW842166
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Active Rheumatoid Arthritis; Rheumatoid Arthritis
A Dose Range Finding Study of JNJ-39758979 in Patients With Active Rheumatoid Arthritis Currently Treated With Methotrexate
The purpose of the study is to assess the efficacy, safety and tolerability of JNJ-39758979 at doses of 10, 30, 100, and 300 mg/day compared with placebo (inactive medical substance) in patients with active rheumatoid arthritis…
- Trial name
- NCT01480388
- Testing
- JNJ-39758979 (10 mg), JNJ-39758979 (30 mg), JNJ-39758979 (100 mg)
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis
A Study to Evaluate Usability of Subcutaneous Auto-injector of CT-P17 in Patients With Active Rheumatoid Arthritis
Clinical trial to evaluate Usability of Subcutaneous Auto-injector of CT-P17 in Patients With Active Rheumatoid Arthritis
- Trial name
- NCT04171414
- Testing
- CT-P17 SC AI (adalimumab)
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Celltrion
Osteoarthritis
Effectiveness and Safety of Synvisc® Versus Usual Treatments in Patients With Knee Osteoarthritis
Comparison of treatment cost of knee osteoarthritis (OA) in patients treated with Synvisc® versus usual treatments as well as evaluation of safety and effectiveness of these treatments.
- Trial name
- NCT02197026
- Testing
- Hylan G-F 20, Standard treatment, Physiotherapy
- Volunteers
- 518 people
- Sponsor
- Boehringer Ingelheim
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