Clinical trials: Arthritis, Unspecified
Rheumatoid Arthritis
Study to Evaluate Safety, Tolerability, and Efficacy of GS-5718 in Participants With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-modifying Antirheumatic Drug(s) (bDMARDs) Treatment
The primary objective of the study is to evaluate the effect of GS-5718 versus placebo for the treatment of rheumatoid arthritis (RA) as measured by change from baseline in Disease Activity Score (DAS) based on 28 joints using…
- Trial name
- NCT05165771
- Testing
- GS-5718, Tofacitinib 5 mg
- Sponsor
- Gilead Sciences
Sjogren's Syndrome
Evaluation of FID 114657 in Sjogren's Syndrome Subjects
The primary objective of this study is to assess the overall Sjogren's Syndrome subject's preference for a particular product. Dry eye symptom relief will also be evaluated based on clinical evaluation and a set of subject…
- Trial name
- NCT01079871
- Testing
- FID 114657 (ORB Preserved Ocular Emulsion)
- Volunteers
- 50 people
- Sponsor
- Alcon Research
Osteoarthritis, Hip, Rheumatoid Arthritis
G7 Freedom Constrained Vivacit-E Liners
The main objectives of this study are to confirm the long-term safety, performance, and clinical benefits of the G7 Freedom Constrained Vivacit-E Acetabular Liners in primary and revision total hip arthroplasty.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures
- Trial name
- NCT05587244
- Testing
- Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
- Where
- 10 sites in United States
- Volunteers
- 202 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
Observational Study of Golimumab Intravenous Infusion
The purpose of this study is to evaluate the incidence and management of infusion reactions with Golimumab intravenous infusion.
- Trial name
- GO-IV (NCT02390700)
- Testing
- Golimumab Intravenous
- Where
- 13 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Janssen Inc.
Rheumatoid Arthritis
Efficacy of Lodotra®(Prednisone) in Reduction of Morning Stiffness Duration(K-IMPROvE)
This study is multicenter, Ph IV, single arm, interventional study to assess relative reduction of morning stiffness of Lodotra® in Rheumatoid Arthritis patients.Study medication will start after study visit at baseline (week 0…
- Trial name
- NCT02072200
- Testing
- Lodotra®
- Where
- South Korea
- Volunteers
- 147 people
- Sponsor
- Mundipharma Korea Ltd
Rheumatoid Arthritis, Inflammatory Disease
A Clinical Study to Assess the Efficacy of Cannabigerol in Patients with Active Rheumatoid Arthritis.
This is a single-group exploratory longitudinal prospective study lasting 8 weeks. The study aims to measure the efficacy of purified cannabigerol (CBG) in patients with active rheumatoid arthritis using laboratory and…
- Trial name
- NCT06513507
- Testing
- Cannabigerol (CBG)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Raphael Pharma
Healthy, Rheumatoid Arthritis
Phase 1 Single and Multiple Dose Study of FPA008 in Healthy Volunteers and Rheumatoid Arthritis Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled study designed in 3 parts to assess the safety, tolerability, and PK of single and multiple ascending doses of FPA008 in adult healthy volunteers (Parts 1 and 2) and…
- Trial name
- NCT01962337
- Testing
- FPA008
- Where
- 6 sites in Hungary, Netherlands and 1 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Five Prime Therapeutics, Inc.
Hip Arthritis
Post Market Clinical Follow-Up Study of Excia T® Hip Prosthesis
Clinical and radiological 10 year results of Excia T® Hip Stem
- Trial name
- NCT02188095
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Arthritis, Rheumatoid
A Study for Patients With Rheumatoid Arthritis on Methotrexate (MTX) With an Inadequate Response to TNFα Inhibitor Therapy
The purpose of this study is to explore whether LY2127399 is effective in relieving signs and symptoms of rheumatoid arthritis (RA) in patients with a history of inadequate response or intolerance to at least 1 Tumor Necrosis…
- Trial name
- NCT00689728
- Testing
- LY2127399
- Where
- 45 sites in United States, Argentina and 8 more
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Osteo Arthritis Knee, Osteoarthritis
Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty
The purpose of this post-market research study is to gather clinical and radiographic (X-ray) information about total knee replacement surgeries completed with the VELYS Robotic-Assisted Solution and with standard manual…
- Trial name
- NCT04730271
- Testing
- Total Knee Replacement
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis, Avascular Necrosis
Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects
primary endpoint of this Study is maintenance of "at least good clinical status" for a period of 10 years following initial implantation among Cormet procedures enrolled inthe pre-market IDE.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- PAS:IDE (NCT00721994)
- Testing
- Cormet Hip Resurfacing System
- Where
- 5 sites in United States
- Volunteers
- 231 people
- Sponsor
- Corin
Rheumatoid Arthritis, Non-Alcoholic Steatohepatitis
A Study to Assess the Safety and Tolerability of LB-P6 and LB-P8 in Healthy Participants
The study is designed to assess the safety and tolerability of multiple ascending doses of LB-P6 or LB-P8 in healthy participants.
- Trial name
- NCT05053165
- Testing
- LB-P6, LB-P8
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- LISCure Biosciences
Rheumatoid Arthritis
Study to Evaluate the Safety, PK, PD and Efficacy of AMG 827 in Adults With Rheumatoid Arthritis
This Phase 1b/2a study will evaluate safety, tolerability pharmacokinetics (PK) and pharmacodynamics (PD) of brodalumab when administered in multiple subcutaneous (SC) and intravenous (IV) doses in patients with active rheumatoid…
- Trial name
- NCT00771030
- Testing
- Brodalumab
- Volunteers
- 40 people
- Sponsor
- Amgen
Osteoarthritis, Hip, Avascular Necrosis of Hip
ROSA® Hip System THA PMCF
This study is a Prospective, Multicenter, Single-Arm, Cohort post-market study to evaluate the accuracy of acetabular implant position using the robotic-arm surgical assistant (ROSA® Hip System).
- Trial name
- NCT05497206
- Testing
- One of the following hip implants may be used within this arm of the study: G7 Acetabular System, Taperloc Complete System, Avenir and Avenir Complete Systems, and Echo Bi-Metric System
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Sjogren Syndrome
Biopsy Based Study to Understand Mechanism of Action of Ianalumab in Salivary Glands and Explore Relationships With Clinical Assessments.
This study aims at elucidating the mechanism of action of ianalumab in salivary glands and explore relationships with clinical assessments
- Trial name
- NCT05124925
- Testing
- Ianalumab
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
A Phase I Clinical Study of VC005 Tablets in Subjects With Rheumatoid Arthritis.
This is a randomized, double-blind, dose-escalating, placebo-controlled phase Ib clinical study.
- Trial name
- NCT05874622
- Testing
- VC005 tablets
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Arthritis, Rheumatoid
A Study Comparing Sirukumab (CNTO 136) Monotherapy With Adalimumab (HUMIRA®) Monotherapy in the Treatment of Active Rheumatoid Arthritis
The primary objective is to investigate the efficacy of sirukumab monotherapy compared with adalimumab monotherapy in biologic naïve subjects with active rheumatoid arthritis who are intolerant to methotrexate, who are considered…
- Trial name
- SIRROUND-H (NCT02019472)
- Testing
- adalimumab 40 mg, sirukumab 100 mg, sirukumab 50 mg
- Where
- 107 sites in United States, Bulgaria and 14 more
- Volunteers
- 559 people
- Sponsor
- Janssen Research & Development, LLC
Rheumatoid Arthritis
A Study of JNJ-67484703 in Participants With Active Rheumatoid Arthritis
The purpose of this study is to evaluate safety and tolerability of JNJ-67484703 administrations in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT04985812
- Testing
- JNJ-67484703
- Where
- 11 sites in United States, Georgia and 4 more
- Volunteers
- 44 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis
Study Comparing a Generic Diclofenac Sodium Topical Gel, 1% to Voltaren in the Treatment of Subjects With Osteoarthritis of the Knee
To establish the therapeutic equivalence and safety of a generic Diclofenac Sodium Topical Gel, 1% with Voltaren® Gel 1% in subjects with osteoarthritis of the knee.
- Trial name
- NCT02121002
- Testing
- Diclofenac Sodium Topical Gel, 1%, Voltaren Topical Gel, 1%, Vehicle Diclofenac Sodium Topical Gel
- Where
- 22 sites in India
- Volunteers
- 1,176 people
- Sponsor
- Amneal Pharmaceuticals, LLC
Knee Osteoarthritis
Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee
The purpose of this study is to determine the safety and effectiveness of micronized dehydrated human amnion chorion membrane as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee…
- Trial name
- NCT03485157
- Testing
- Micronized dHACM, Saline
- Where
- 17 sites in United States
- Volunteers
- 447 people
- Sponsor
- MiMedx Group, Inc.
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