Clinical trials: Arthritis, Unspecified
Healthy Volunteers, Rheumatoid Arthritis
A Study of Intravenous CPTX2309 in Healthy Participants and Participants With Moderate to Severe Rheumatoid Arthritis (RA) or Systemic Lupus Erythematosus (SLE)
The purpose of this study is to assess the safety and tolerability of CPTX2309 in healthy adult participants and adult participants with moderate to severe rheumatoid arthritis or systemic lupus erythematosus.
- Conditions
- Healthy Volunteers, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT06917742
- Testing
- CPTX2309
- Where
- 3 sites in Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Capstan Therapeutics
Joint Diseases
EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® Revision Tibial System and EVOLUTION® Revision STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert.
- Trial name
- NCT06142669
- Testing
- EVOLUTION® Revision Tibial System and EVOLUTION® Stemmed CS Femur with the EVOLUTION® MP CS Tibial Insert
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Ulcerative Colitis, Spondyloarthropathy
Real-world Effectiveness of Tofacitinib on Ulcerative Colitis Associated Spondyloarthropathy
Tofacitinib (TOFA) is a JAK inhibitor already used in rheumatology for the treatment of moderate-to-severe active rheumatoid arthritis and psoriatic arthritis in adult patients who have responded inadequately to, or who are…
- Trial name
- RETUCAS (NCT05431283)
- Testing
- Tofacitinib
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Italian Group for the study of Inflammatory Bowel Disease (IG-IBD)
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
Rheumatoid Arthritis
Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a frequent inflammatory arthritis that can lead to severe joint deformity and often requires orthopaedic surgical interventions.
- Trial name
- NCT02242474
- Testing
- Anti-TNF suspended perioperatively, Anti-TNFα continued perioperatively
- Where
- Canada
- Volunteers
- 660 people
- Sponsor
- CHU de Quebec-Universite Laval
Osteoarthritis, Hip, Osteoarthritis, Knee
Evaluation of Teleconsulting on Rehabilitation After Hip and Knee Surgical Procedures
The objective of this study is to assess the medical and economic relevance of teleconsulting for Rehabilitation After Hip and Knee Surgical Procedures.
- Trial name
- SSRHAD (NCT02229279)
- Testing
- Teleconsulting
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis of Knee
Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries
Total Knee Replacement surgery is common procedure that is usually done for patients suffering from persistent pain with limitation of movement.
- Trial name
- NCT06651762
- Testing
- unilateral Radiofrequency, bilateral Radiofrequency, Epidural
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
Arthritis, Rheumatoid
A Study To Describe The Use Of Tofacitinib After Use Of Rituximab In Patients With Rheumatoid Arthritis In A Real-World Setting
This study is to characterize the use of tofacitinib after use of rituximab in patients with Rheumatoid Arthritis in a real-world setting.
- Trial name
- NCT05487703
- Where
- Morocco
- Volunteers
- 318 people
- Sponsor
- Pfizer
Ankylosing Spondylitis
NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis
To evaluate the impact of treatment with a non-steroidal anti-inflammatory drug (NSAID) - Celecoxib - when added to anti-tumour necrosis factor (TNF) therapy - Golimumab - as compared to anti-TNF therapy (Golimumab) alone on…
- Trial name
- CONSUL (NCT02758782)
- Testing
- Golimumab, Celecoxib
- Where
- 19 sites in Germany
- Volunteers
- 156 people
- Sponsor
- Charite University, Berlin, Germany
Rheumatoid Arthritis
Secukinumab Efficacy and Safety Study in Patients With Rheumatoid Arthritis and Inadequate Response to Anti-TNFα Agents.
This study will provide efficacy and safety data of the secukinumab pre-filled syringe (PFS) for subcutaneous self-administration in patients with active rheumatoid arthritis who are intolerant to or have had an inadequate…
- Trial name
- REASSURE2 (NCT01770379)
- Testing
- Secukinumab (AIN457)
- Where
- 77 sites in United States, Argentina and 14 more
- Volunteers
- 242 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis
Safety and Efficacy of Tofacitinib vs Methotrexate in the Treatment of Psoriatic Arthritis
Title Safety and Efficacy of Tofacitinib vs Methotrexate in the treatment of Psoriatic Arthritis- An Open Label Randomized single center study Psoriatic arthritis is defined as an inflammatory arthropathy associated with skin…
- Trial name
- PsOLSET-BD (NCT03736161)
- Testing
- Group A- Tofacitinib, Group B- Methotrexate
- Where
- Bangladesh
- Volunteers
- 61 people
- Sponsor
- Globe Pharmaceuticals Limited
Osteoarthritis, Knee, Osteoarthritis, Hip
Telerehabilitation for Hip and Knee Osteoarthritis
Digital health utilization in the form of telerehabilitation is a popular technology that is very little researched for musculoskeletal disorders particularly hip and knee osteoarthritis (OA).
- Trial name
- NCT06901661
- Testing
- Telerehabilitation, Standard care
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Osteoarthritis, Knee, Pain, Joint
Assessment of the Effect of Spa Treatment on Rheumatological Conditions
1. Primary outcome measure: measuring the effect of spa treatment in patients suffering from lower limb osteoarthritis or any other lower limb rheumatological condition.
- Conditions
- Osteoarthritis, Knee, Pain, Joint, Lower Back Pain, Rheumatic Diseases
- Trial name
- CONTREXEVILLE (NCT03538470)
- Testing
- Spa Treatment
- Where
- 4 sites in France
- Volunteers
- 150 people
- Sponsor
- SAEML Contrexéville
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Osteoarthritis
Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery
The investigators are testing the hypothesis that administering 2L of body temperature warmed lactated ringer's intravenously prior to surgery can optimize the postoperative and recovery of patients undergoing total hip and total…
- Trial name
- Hydration (NCT02638623)
- Testing
- Lactated Ringer
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Knee Osteoarthritis
Observational Clinical Investigation of Arthrosamid in Knee Osteoarthritis
This is a prospective, long-term, observational, all-comers, open-label, multi-centre clinical investigation enrolling subjects with knee osteoarthritis who is eligible for treatment with Arthrosamid® according to the Instruction…
- Trial name
- LUNA (NCT05057559)
- Where
- 9 sites in Denmark, France and 3 more
- Volunteers
- 201 people
- Sponsor
- Contura
Knee Osteoarthritis
Exercise With Dual Task in Knee Osteoarthritis
The purpose of this study is to evaluate the neuromuscular and perceptual responses, pain intensity and performance in patients with severe knee osteoarthritis in a preoperative setting with low-load resistance training with a…
- Trial name
- DTOA (NCT05280080)
- Testing
- Resistance exercise
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- University of Valencia
Ankylosing Spondylitis, Exercise Training
Respiratory Training in Individuals with Ankylosing Spondylitis
This study was designed to investigate and compare the effects of standard diaphragmatic breathing and physiotherapy exercises versus 360-degree expandable diaphragmatic breathing and physiotherapy exercises on respiratory…
- Conditions
- Ankylosing Spondylitis, Exercise Training, Diaphragm, Mobility
- Trial name
- NCT06490796
- Testing
- Expanded diaphragm exercise, Standard diaphragm exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir University of Economics
Rheumatoid Arthritis
An Open-label Extension Study of Certolizumab Pegol in Chinese Patients With Rheumatoid Arthritis Who Enrolled in RA0044
This study will continue to evaluate the safety \& efficacy of Certolizumab Pegol (CZP) for 6 months in Chinese subjects with active Rheumatoid Arthritis who participated in RA0044.
- Trial name
- RAPID-C OLE (NCT02319642)
- Testing
- Certolizumab Pegol
- Where
- 30 sites in China
- Volunteers
- 347 people
- Sponsor
- UCB Pharma SA
Rheumatoid Arthritis
Effects of Tofacitinib on Body Composition, Bone Mineral Density and Bone Marrow Adiposity in Patients With Rheumatoid Arthritis: the TOFAT Project
Inflammatory rheumatic diseases (IRD), such as rheumatoid arthritis, are characterized by adverse changes in body composition. Lean mass and bone mineral density are usually reduced while adiposity (total fat mass, visceral…
- Trial name
- TOFAT (NCT04175886)
- Testing
- Tofacitinib
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
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