Clinical trials: Arthritis;Inflammatory
Axial Spondyloarthrithis, Ankylosing Spondylitis
Study to Evaluate Maintenance of Sustained Remission of axSpA With CZP Compared to Placebo
Patients receive study drug for one year (Part A). If, after the initial run-in phase, a sustained remission is reached they will be randomly split into one of three dose groups for another year (Part B).
- Trial name
- C-OPTIMISE (NCT02505542)
- Testing
- Certolizumab Pegol
- Where
- 108 sites in United States, Belgium and 12 more
- Volunteers
- 736 people
- Sponsor
- UCB BIOSCIENCES GmbH
Rheumatoid Arthritis
A Study of the Safety and Effectiveness of Liquid Certolizumab Pegol in the Treatment of Signs and Symptoms of Rheumatoid Arthritis and in Prevention of Joint Damage in Patients With Active Rheumatoid Arthritis
An open ended study in which patients who completed the preceding double-blind study NCT00160602 are given Certolizumab Pegol and assessed for signs and symptoms of Rheumatoid Arthritis.
- Trial name
- NCT00160641
- Testing
- Certolizumab Pegol
- Where
- 67 sites in United States, Bulgaria and 11 more
- Volunteers
- 567 people
- Sponsor
- UCB Pharma
Osteoarthritis, Knee
A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain
The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain. The study drugs will be given as an injection under the skin and as an oral capsule.
- Trial name
- NCT02192190
- Testing
- LY2951742, Celecoxib
- Where
- 38 sites in United States
- Volunteers
- 268 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis (OA)
Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA
This study explored the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage.
- Trial name
- NCT04097379
- Testing
- LRX712
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Efficacy, Safety and Tolerability of Denosumab in the Treatment of Rheumatoid Arthritis
This study will determine the efficacy, safety, and tolerability of denosumab (AMG 162) in the treatment of Rheumatoid Arthritis (RA).
- Trial name
- NCT00095498
- Testing
- denosumab
- Volunteers
- 227 people
- Sponsor
- Amgen
Osteoarthritis
Tanezumab in Osteoarthritis of the Hip or Knee (2)
Test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis
- Trial name
- NCT00863304
- Testing
- tanezumab 10 mg, tanezumab 5 mg, naproxen
- Where
- 95 sites in United States
- Volunteers
- 849 people
- Sponsor
- Pfizer
Symptomatic Knee Osteoarthritis
Study of Efficacy, Safety and Tolerability of DFV890 in Patients With Knee Osteoarthritis
This was a double-blinded, two-arm, phase 2a study to assess efficacy, safety and tolerability of DFV890 in participants with symptomatic knee osteoarthritis.
- Trial name
- NCT04886258
- Testing
- DFV890
- Where
- 31 sites in United States, Argentina and 6 more
- Volunteers
- 115 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
A Study in Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and tolerability of multiple doses of LY2439821 in Japanese patients with rheumatoid arthritis.
- Trial name
- NCT01253265
- Testing
- LY2439821
- Where
- 8 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis
The purpose of this proposed study is to conduct a trial with knee osteoarthritis (OA) patients using the diclofenac gel.
- Trial name
- NCT01383954
- Testing
- Diclofenac Gel
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Brigham and Women's Hospital
Intra-articular Injections
Use of BIP-Needles in Rheumatologic Injections
The study focuses on needle guidance in rheumatologic operations - glucocorticoid injections inside joint capsules specifically.
- Trial name
- NCT02605928
- Testing
- Injeq Bioimpedance Probe (BIP) Needle
- Where
- Finland
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Injeq Ltd
Osteoarthritis
Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee
An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in patients who have pain associated with osteoarthritis of the knee despite…
- Trial name
- NCT05377489
- Testing
- RTX-GRT7039
- Where
- 96 sites in United States, Bulgaria and 5 more
- Volunteers
- 714 people
- Sponsor
- Grünenthal GmbH
Gastric Ulcer, Duodenal Ulcer
Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID
The purpose of this study is to assess the efficacy of esomeprazole (D961H) 20 mg versus placebo once daily for up to 24 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- NCT00542789
- Testing
- Esomeprazole
- Where
- 39 sites in Japan
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
Knee Osteoarthritis
Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis
The purpose of this study is to examine the effectiveness of standard physical therapy and an internet-based exercise program for people with knee osteoarthritis (OA).
- Trial name
- PATH-IN (NCT02312713)
- Testing
- Internet Based Exercise Training, Physical Therapy
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of North Carolina, Chapel Hill
Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE)
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders
This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring IS medications.
- Conditions
- Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Pemphigus Vulgaris, Multiple Sclerosis (MS)
- Trial name
- NCT05000216
- Testing
- Moderna mRNA-1273, BNT162b2, Ad26.COV2.S
- Where
- 29 sites in United States
- Volunteers
- 258 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Osteoarthritis, Knee
Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement
Tranexamic acid (TXA) is a drug that is being used more frequently at the Hospital for Special Surgery to lessen the amount of blood loss after total knee replacement (TKR).
- Trial name
- TXA Knee (NCT02540226)
- Testing
- Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Uveitis, JIA
Adalimumab in JIA-associated Uveitis Stopping Trial
The proposed study is a stratified, block-randomized, double-masked, controlled trial to determine the feasibility of discontinuing adalimumab treatment in patients with quiescent uveitis associated with juvenile idiopathic…
- Trial name
- ADJUST (NCT03816397)
- Testing
- Adalimumab
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 87 people
- Sponsor
- Nisha Acharya
Rheumatoid Arthritis
Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis
The purpose of this study is to examine the effects of milnacipran for the treatment of pain in rheumatoid arthritis in older adults.
- Trial name
- NCT01225991
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, Los Angeles
Arthritis, Psoriatic
Study Evaluating Safety and Adherence to Treatment With Etanercept in Adults With Psoriatic Arthritis
The aim of this study is to evaluate if the data obtained in controlled clinical trials are confirmed when Enbrel is used in usual clinical practice in Belgium according to local reimbursement criteria.
- Trial name
- PROVE (NCT00938015)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 303 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Observational Study of Tocilizumab in Participants With Rheumatoid Arthritis in Australia
This multi-center, observational study will evaluate the treatment patterns in clinical practice, efficacy and safety of tocilizumab in participants with rheumatoid arthritis (RA) who have had an inadequate response (or were…
- Trial name
- NCT01683604
- Testing
- Observational study
- Where
- 7 sites in Australia
- Volunteers
- 37 people
- Sponsor
- Hoffmann-La Roche
Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye
Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease
The goal of this research is to determine if the Tangible Boost system adequately replenishes the Hydra-PEG coating on the surface of a rigid contact lens.
- Conditions
- Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye, Sjogren's Syndrome, Dry Eye
- Trial name
- NCT04313725
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Tangible Science
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