Clinical trials: Arthritis
Healthy
A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fasting Condition
The study was conducted as an open labeled, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing acetaminophen extended release gelcaps 650 mg of OHM Laboratories…
- Trial name
- NCT01073709
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Men at Risk for Symptomatic Knee Osteoarthritis
The purpose of this research study is to determine whether low intensity resistance training with concurrent application of a peripheral blood flow restriction device to the exercising limb will elicit increased quadriceps…
- Trial name
- PBFR3 (NCT01487525)
- Testing
- Double leg press with partial blood flow restriction, Double leg press without partial blood flow restriction
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteo Arthritis Knee, Osteoarthritis
Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Intraarticular Injection
- Trial name
- NCT07489521
- Testing
- Arthrosamid® 2.5% iPAAG injectable implant, Steroid Drug
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cappagh National Orthopaedic Hospital
Anesthesia Morbidity, Osteoarthritis, Knee
Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System
The study is a retrospective cohort study of adult patients undergoing outpatient primary unilateral total knee or total hip replacement surgeries from 2017 to 2019 assessing for difference in anesthetic techniques and outcomes.
- Conditions
- Anesthesia Morbidity, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04203732
- Testing
- Anesthesia Type
- Where
- United States
- Volunteers
- 12,466 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Rheumatoid Arthritis, Inflammatory Arthritis
Sleep and Exercise in Rheumatoid Arthritis
Regular physical activity is important for people with rheumatoid arthritis (RA). Sleep requirements for adults should be on a 'sleep needs spectrum' of between 7 to 9 hours per day.
- Trial name
- NCT03140995
- Testing
- Walking Programme
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital of Limerick
Psoriasis, Psoriatic Arthritis
Cytokine Expression in Psoriasis Patients With and Without Joint Involvement
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution of cytokines to the presence…
- Trial name
- CYNEPSA (NCT05307809)
- Testing
- Blood sample collection, Skin sample collection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Knee Arthritis, Osteoarthritis
Results Between Robotic-assisted and Manual Total Knee Arthroplasty With Kinematic Alignment
This randomised controlled trial will include patients with end-stage osteoarthritis of the knee undergoing primary TKR. Patients meeting the criteria that consent to be in the study will be randomised at a ratio of 1:1 to either…
- Trial name
- TKA TKR (NCT07452809)
- Testing
- preoperative HKA, preoperative CPAK, preoperative Oxford Knee Score
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jakub Błaszczyk
Rheumatoid Arthritis
Addition of H.P. Acthar Gel to Treatment Regimen of Patients With Rheumatoid Arthritis
This small study is to investigate the efficacy and safety of Acthar as an adjunct therapy in patients with active rheumatoid arthritis (RA) who have had an inadequate response to disease modifying antirheumatic drugs (DMARDs)…
- Trial name
- NCT02434757
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ronald J. Rapoport, MD
Rheumatoid Arthritis
A Clinical Trial of Safety and Tolerance of TQH3821 Tablets in Adult Healthy Subjects
This study was a randomized, double-blind, placebo-controlled phase I clinical trial of TQH3821 in adult healthy subjects, which plans to recruit 72 healthy subjects.
- Trial name
- NCT05380934
- Testing
- TQH3821 tablets, Methotrexate tablets
- Where
- China
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Patient Satisfaction, Hip Osteoarthritis
Dual Mobility Cup: Does it Improve Patient's Satisfaction After Total Hip Arthroplastry?
Although the success of total hip arthroplasty, many patients were dissatisfied postoperatively. Patient's reported outcome measures become of a great importance in assessment of the results after joint replacement.
- Trial name
- NCT04333316
- Testing
- large head, dual mobility cup
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tanta University
Treatment of Arthritis
Comparative Clinical Efficacy and Safety of Coded Polyherbal Medicine for the Management of Arthritis
This study aimed to develop two poly herbal capsule formulations for arthritis through granulation and conduction of their clinical trial in order to achieve quality, efficacy and safety.
- Trial name
- NCT03506919
- Testing
- Allopurinol
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shifa Ul Mulk Memorial Hospital
Pharmacokinetics of ASP015K, Bioavailability of ASP015K
A Single Oral Dose Study to Compare the Bioavailability Between Two Different Tablet Formulations and Assess if There is a Food Effect With the New Formulation
The purpose of this study is to determine the bioavailability and pharmacokinetics between two different formulations of ASP015K tablets and determine the food effect on the absorption of the new formulation.
- Conditions
- Pharmacokinetics of ASP015K, Bioavailability of ASP015K, Healthy Subjects
- Trial name
- NCT01484964
- Testing
- ASP015K
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Rheumatoid Arthritis, Inflammation
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis
Recent studies show beneficial effect of the inhibition of interleukin-6 (IL-6) activity on vascular and left ventricular (LV) function.
- Trial name
- NCT03288584
- Testing
- Tocilizumab (Actemra®), Other biological agent, Corticosteroid and non-biological agents.
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Meniscus Injury, Meniscectomy
Biomechanical Osteoarthritis Outcomes in Meniscectomy Patients
The key aim of this study is to examine biomechanical measures associated with osteoarthritis (OA) progression in patients who have lateral and medial menisci injuries during various tasks.
- Conditions
- Meniscus Injury, Meniscectomy, Osteoarthritis, Knee
- Trial name
- BOOM (NCT03350204)
- Testing
- Meniscectomy, Helathy control comparison
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Salford
Rheumatoid Arthritis
Investigate the Safety, Tolerability and Pharmacokinetics of FBL-MTX
This is a prospective, single-center, randomized, double-blind, placebo-controlled, single-ascending dose (SAD) phase 1 study to evaluate the safety, tolerability and pharmacokinetics of FBL-MTX in healthy male and female…
- Trial name
- FolSmart (NCT05117593)
- Testing
- FBL-MTX
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- SOLFARCOS - Pharmaceutical and Cosmetic Solutions Ltd
Knee Osteoarthritis
Veteran Affairs Osteoarthritis Knee Study
A clinical study at the Dallas Veterans Affairs, is being proposed to test the efficacy of a novel electrical stimulation platform named the Pro-Sport Ultra® device by AVAZZIA to reduce pain and increase activity level in…
- Trial name
- NCT04698733
- Testing
- BEST™ HVPC microcurrent electrical stimulation Pro-Sport Ultra® device
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Avazzia, Inc
Rheumatoid Arthritis
The Health Log: A Randomized Clinical Trial
The goal of the present study is to determine if a health management tool improves self-efficacy, satisfaction with the doctor's visit, and agreement of the statement "How satisfied are you that your concerns were addressed…
- Trial name
- NCT01913080
- Testing
- Health Log
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Spondylitis, Ankylosing
Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED)
This is an open-label, controlled sub-study to the parent protocol (P04041, NCT00779935) to examine the expression profile of genes in patients in the active stage of ankylosing spondylitis (AS) compared to the healthy population…
- Trial name
- NCT00778869
- Testing
- Remicade
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis - Rheumatism
Application of Warm Water and Warm Salt Water to Patients With Rheumatoid Arthritis
This pretest-posttest randomized controlled study aimed to determine the effect of warm salt water and warm water bath applied to the hands and feet on pain, fatigue, sleep quality, and functional capacity in patients with…
- Trial name
- NCT05888220
- Testing
- warm salt water bath
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Osteoarthritis of Hip
Management of Postoperative Pain After Total Hip Arthroplasty
Orthopedic surgery is reportedly among the most painful surgical procedures. Surgical damage following major orthopedic surgery often involves a large, deep incision with considerable tissue dissection and muscle, bone, and…
- Trial name
- NCT01040273
- Testing
- Bupivacaine
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
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