Clinical trials: Arthritis
RA
To Evaluate Sarilumab - SAR153191 (REGN88) - Auto-injector Device In Patients With Rheumatoid Arthritis
Primary Objective: To collect real-use data of the sarilumab auto-injector device (AID) used by rheumatoid arthritis (RA) participants.
- Trial name
- SARIL-RA-EASY (NCT02057250)
- Testing
- Sarilumab, Auto-Injector Device (AID), Pre-filled Syringe (PFS)
- Where
- 53 sites in United States, Chile and 4 more
- Volunteers
- 217 people
- Sponsor
- Sanofi
Psoriatic Arthritis
Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis in Normal Medical Practice
This study is a documentation of effectiveness and safety of Humira in patients with psoriatic arthritis.
- Trial name
- NCT01111240
- Where
- 509 sites in Germany
- Volunteers
- 4,635 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rheumatoid Arthritis
A Study To Assess the Immune Response Following Administration Of Influenza and Pneumococcal Vaccines To Subjects With Rheumatoid Arthritis Receiving CP-690,550 Or Placebo
A Randomized, Double Blind, Placebo Controlled Phase 2 Study To assess the Immune Response Following Administration of Influenza and Pneumococcal Vaccines to Subjects with Rheumatoid Arthritis receiving CP-690,550 with and…
- Trial name
- NCT01359150
- Testing
- CP-690,550
- Where
- 57 sites in United States, Poland
- Volunteers
- 223 people
- Sponsor
- Pfizer
Arthritis, Rheumatoid
Oral Baricitinib (LY3009104)Treatment in Japanese Participants With Active Rheumatoid Arthritis on Background Methotrexate Therapy
This is a Phase 2b, outpatient, randomized, double-blinded (with a single-blind extension), placebo-controlled, dose-ranging, parallel-group study of baricitinib (LY3009104) in Japanese participants with active rheumatoid…
- Trial name
- NCT01469013
- Testing
- Baricitinib, Methotrexate
- Where
- 14 sites in Japan
- Volunteers
- 145 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate
This was a Phase II, randomized, open-label, multicenter study designed to evaluate the immune response to vaccines after administration of 1000 mg of rituximab in subjects with active rheumatoid arthritis (RA) who were receiving…
- Trial name
- SIERRA (NCT00282308)
- Testing
- Rituximab, Methotrexate, Methylprednisone
- Where
- 34 sites in United States
- Volunteers
- 103 people
- Sponsor
- Genentech, Inc.
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Rotator Cuff Deficiency, Glenohumeral Arthritis
Retrospective Encore Reverse Shoulder Prosthesis Study
The purpose of this study is to evaluate the survivorship and efficacy of the Encore Reverse Shoulder Prosthesis in a group of no more than 50 subjects for whom data collection has already begun.
- Trial name
- NCT00765037
- Testing
- Encore Reverse Shoulder Prosthesis
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis
Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated injections of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05248386
- Testing
- RTX-GRT7039
- Where
- 103 sites in Canada, Czechia and 7 more
- Volunteers
- 469 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis, Knee, Osteoarthritis, Hip
Liposomal Bupivacaine Versus Standard Analgesia in Total Joint Arthroplasty (TJA)
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis, Shoulder
- Trial name
- NCT02197273
- Testing
- Liposomal bupivacaine, Standard of care analgesia
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- OhioHealth
Gout
RDEA3170 Bioavailability Study
This is a Phase 1, randomized, open-label, 4-way crossover pharmacokinetic (PK) and pharmacodynamic (PD) study in healthy adult male subjects designed to assess the relative bioavailability of RDEA3170 2.5 mg tablets administered…
- Trial name
- NCT02336594
- Testing
- RDEA3170 10 mg, RDEA3170 2.5 mg
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ardea Biosciences, Inc.
Osteoarthritis
Study of CG100649 Versus Celecoxib in Osteoarthritis Patients
This is a double-blind, randomized, multicenter, phase 2b, noninferiority comparison of two active dose levels of CG100649 vs. a standard anti-arthritic dose of celecoxib (Celebrex).
- Trial name
- NCT01341405
- Testing
- CG100649, Celecoxib
- Where
- South Korea
- Volunteers
- 125 people
- Sponsor
- CrystalGenomics, Inc.
Arthritis, Rheumatoid Arthritis
Wright Foot & Ankle Post-Market Observational Study
WRIGHT FOOT \& ANKLE POST-MARKET OBSERVATIONAL STUDY, Multi-Year, Multi-Site, Multi-Device, Post-Market Observational Study, 10 sites, a minimum of 40 patients per device
- Conditions
- Arthritis, Rheumatoid Arthritis, Fracture, Trauma Injury
- Trial name
- NCT04118894
- Testing
- Foot and Ankle Devices
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA
A Multicener, Postmarketing Study Evaluating the Transfer of Cimzia From the Mother to the Infant Via the Placenta
The primary purpose is to assess whether there is transfer of Certolizumab Pegol (CZP) from pregnant women receiving treatment with Cimzia® across the placenta to infants by evaluating the concentration of CZP in the plasma of…
- Conditions
- Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA, Ankylosing Spondylitis, Crohn's Disease
- Trial name
- CRIB (NCT02019602)
- Testing
- Blood sampling from mother, Blood sampling from infant, Blood sampling from umbilical cord
- Where
- 8 sites in United States, France and 2 more
- Volunteers
- 37 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Arthritis, Psoriatic, Psoriasis
Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists
The purpose of this study is to evaluate the safety and effectiveness of etanercept under usual care settings in patients with PsA treated by rheumatologists.
- Conditions
- Arthritis, Psoriatic, Psoriasis, Skin Diseases, Papulosquamous
- Trial name
- NCT00293722
- Testing
- Etanercept
- Where
- Germany
- Volunteers
- 1,308 people
- Sponsor
- Pfizer
Ankylosing Spondylitis
Comparative Evaluation of Pharmacokinetics and Safety of BCD-055 and Remicade in Patients With Ankylosing Spondylitis
ASART-1 clinical study is a phase 1 study which carried out to establish the pharmacokinetic equivalence and equal safety profile of BCD-055 (infliximab manufactured by JSC BIOCAD, Russia) and Remicade when used as multiple IV…
- Trial name
- NCT02359903
- Testing
- Infliximab (BCD-055), Infliximab (Remicade)
- Where
- 6 sites in Belarus, Russia
- Volunteers
- 90 people
- Sponsor
- Biocad
Ankylosing Spondylitis
A Study to Evaluate the Long Term Safety and Efficacy of Bimekizumab in Subjects With Ankylosing Spondylitis
This is a study to assess the long term safety and tolerability of bimekizumab in subjects with ankylosing spondylitis
- Trial name
- BE AGILE 2 (NCT03355573)
- Testing
- Bimekizumab
- Where
- 50 sites in United States, Bulgaria and 8 more
- Volunteers
- 255 people
- Sponsor
- UCB Biopharma SRL
Rheumatoid Arthritis
A Pharmacokinetic/Pharmacodynamic Study Comparing PF-05280586 To Rituximab In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To TNF Inhibitors (REFLECTIONS B328-01)
In this study, patients with moderate to severe rheumatoid arthritis who are being treated with methotrexate will receive 2 intravenous treatments with either PF-05280586 or Rituxan (Rituximab) or MabThera (Rituximab).
- Trial name
- REFLECTIONS (NCT01526057)
- Testing
- PF-05280586, MabThera, Rituxan
- Where
- 84 sites in United States, Australia and 8 more
- Volunteers
- 220 people
- Sponsor
- Pfizer
Osteoarthritis
Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP)
This is a multi-phase study that will develop and test an osteoarthritis (OA) primary care Physical activity Care Pathway (OA-PCP), a scalable intervention that includes: 1) a practical process for physical inactivity screening…
- Trial name
- NCT03780400
- Testing
- Osteoarthritis Physical Activity Care Pathway
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Knee, Pain
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol HCl / Contramid® Tablets to Twice Daily Tramadol HCl (SR) for the Treatment of Osteoarthritis of the Knee
A randomised, multi-centre, double-blind, double dummy, two arm parallel design study to compare the efficacy, safety, and clinical benefit of the test and reference product after treatment for 84 days in patients with…
- Trial name
- NCT00950651
- Testing
- Tramadol HCl Contramid® Once A Day, Tramadol HCl Twice a day
- Volunteers
- 431 people
- Sponsor
- Labopharm Inc.
Arthritis, Rheumatoid
Study to Evaluate Safety and Effects of Tofacitinib and Biologic Disease Modifying Antirheumatic Drugs in People Treated for Rheumatoid Arthritis
This is a secondary structured database observational study conducted in Rheumatoid Arthritis (RA) patients treated with biologic and nonbiologic DMARDs, including tofacitinib, collected as part of the CorEvitas Japan RA…
- Trial name
- NCT05572567
- Where
- Japan
- Volunteers
- 1,972 people
- Sponsor
- Pfizer
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