Clinical trials: Arthritis
Rheumatoid Arthritis
Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid Arthritis
The purpose of this study is to determine the efficacy and safety of three different Tregalizumab doses in combination with Methotrexate (MTX) in subjects who have active rheumatoid arthritis and an inadequate response to MTX…
- Trial name
- 986 (NCT01999192)
- Testing
- Tregalizumab
- Where
- 84 sites in United States, Bulgaria and 12 more
- Volunteers
- 321 people
- Sponsor
- Biotest
Osteoarthritis, Rheumatoid Arthritis
Robotic Arm Assisted Total Knee Arthroplasty
The Investigation will be conducted as a single-submission, multi-center study with approval from and in compliance of the Western Institutional Review Board (WIRB).
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT02058069
- Testing
- Robotic Arm Assisted Total Knee Arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- MAKO Surgical Corp.
Osteoarthritis, Knee
Proof of Concept Study of PEMF (Pulsed Electromagnetic Field) Therapy in Subjects With Osteoarthritis of the Knee
To investigate the effect of PEMF treatment when administered twice daily over a 90-day period by looking at synovial fluid in subjects with osteoarthritis of the knee.
- Trial name
- NCT02696083
- Testing
- Provant Therapy System
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Osteoarthritis
Study of CG100649 Versus Celecoxib in Osteoarthritis Patients
This is a double-blind, randomized, multicenter, phase 2b, noninferiority comparison of two active dose levels of CG100649 vs. a standard anti-arthritic dose of celecoxib (Celebrex).
- Trial name
- NCT01341405
- Testing
- CG100649, Celecoxib
- Where
- South Korea
- Volunteers
- 125 people
- Sponsor
- CrystalGenomics, Inc.
Inflammation, Rheumatoid Arthritis
First-in-man Trial of NNC0142-0002 in Patients With Rheumatoid Arthritis
This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety, tolerability, pharmacokinetic (the effect of the body on the investigated drug) and signs of clinical efficacy of increasing single…
- Trial name
- NCT00927927
- Testing
- NNC0142-0002
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Hip
3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Spinal anesthesia is commonly utilized for hip replacement surgery. Different medications used for spinal anesthesia work for different lengths of time.
- Trial name
- NCT03948386
- Testing
- isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine
- Where
- 2 sites in United States
- Volunteers
- 159 people
- Sponsor
- Thomas Jefferson University
Rheumatoid Arthritis
Study To Evaluate The Safety And Efficacy Of ILV-094 In Subjects With Rheumatoid Arthritis
The primary objective of this study is to assess the safety and efficacy of different dose regimens of ILV-094 compared with placebo, administered subcutaneously to subjects with active rheumatoid arthritis who are taking…
- Trial name
- NCT00883896
- Testing
- ILV-094
- Where
- 52 sites in United States, Belgium and 9 more
- Volunteers
- 195 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Study Comparing The Effect On Disease Activity When Reducing Or Discontinuing Etanercept In Subjects With RA
This study involves Rheumatoid Arthritis patients in regular clinical setting who are already on etanercept treatment and are in remission or in a low disease activity (LDA) state, and is intended to identify parameters that can…
- Trial name
- DOSERA (NCT00858780)
- Testing
- Etanercept
- Where
- 16 sites in Denmark, Finland and 4 more
- Volunteers
- 91 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Wearable LITUS Device for Osteoarthritis of the Knee: a Randomized Double-Blind Placebo-Controlled Trial
The purpose of this study is to measure the effectiveness of a wearable therapeutic ultrasound device in patients with stage I and stage II knee osteoarthritis.
- Trial name
- NCT02083861
- Testing
- Sam Ultrasonic Diathermy Device
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- ZetrOZ, Inc.
Congenital Heart Block, Neonatal Lupus
Preventive Approach to Congenital Heart Block With Hydroxychloroquine
Women with antibodies to proteins called SSA/Ro and or SSB/La face a 2% chance of having a child with a life threatening heart condition regardless of whether they have very active lupus, are in remission, or have only vague…
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-Associated Heart Block
- Trial name
- PATCH (NCT01379573)
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- NYU Langone Health
Osteoarthritis, Avascular Necrosis
Trilogy AB Acetabular Hip System Post Approval Study
This is a post-approval study with prospective enrollment in the United States and a retrospective enrollment outside the United States to obtain functional, quality of life and radiographic data, which will facilitate assessment…
- Conditions
- Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis
- Trial name
- NCT00715026
- Testing
- Trilogy AB Acetabular Hip Implant System
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured.
- Trial name
- NCT03628508
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Rheumatoid Arthritis
Follow-up of Rheumatoid Arthritis (RA) Moderate to Low Disease Activity Study
To continue to assess the clinical safety and efficacy of Certolizumab Pegol as add-on therapy with stable-dose Disease Modifying Anti-Rheumatic Drugs (DMARDs)
- Trial name
- CERTAIN 2 (NCT00843778)
- Testing
- Certolizumab Pegol
- Where
- 25 sites in Austria, France and 3 more
- Volunteers
- 131 people
- Sponsor
- UCB Pharma
Osteoarthritis, Rheumatoid Arthritis
Clinical Study Comparing Two Implant Surface Finishes in Patients Undergoing Cementless Total Hip Replacement
Prospective, randomized study of Summit Porocoat versus Summit DuoFix HA in total hip arthroplasty
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- SPD (NCT00306917)
- Testing
- non-coated femoral hip stem, coated femoral hip stem
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- DePuy Orthopaedics
Rheumatoid Arthritis
A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate
This was a Phase II, randomized, double-blind, multicenter study designed to evaluate the safety and efficacy of rituximab, administered at two different regimens for 2 years, in patients with moderate to severe active rheumatoid…
- Trial name
- RUMBA (NCT00243412)
- Testing
- folate, methotrexate, methylprednisolone
- Volunteers
- 42 people
- Sponsor
- Genentech, Inc.
Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease
Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty.
This is a single center, prospective, randomized controlled study. The primary objective of this study is to measure migration over two years with RSA.
- Conditions
- Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity
- Trial name
- NCT03409666
- Testing
- Taperloc Complete Microplasty stem, Taperloc Complete Reduced Distal stem
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Zimmer Biomet
Osteoarthritis of the Knee or Hip
Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
The primary objective of the study is to describe the safety and tolerability of fasinumab, including adverse events of special interest (AESIs), in patients with pain due to radiographically-confirmed OA of the knee or hip.
- Trial name
- FACT LTS & OA (NCT02683239)
- Testing
- Fasinumab
- Where
- 149 sites in United States, Bulgaria and 19 more
- Volunteers
- 5,331 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthritis
Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis
The purpose of this study is to determine whether the combination of Chondroitin sulfate (CS) and Glucosamine Hydrochloride (GH) has similar efficacy to Celecoxib (CE) in the treatment of patients with moderate to severe knee…
- Trial name
- MOVES (NCT01425853)
- Testing
- Chondroitin/Glucosamine (Droglican), Celecoxib
- Where
- Spain
- Volunteers
- 606 people
- Sponsor
- Bioiberica
Rheumatoid Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis
This open-label study will evaluate the safety, tolerability and efficacy of RoActemra/Actemra (tocilizumab) in patients with moderate to severe active rheumatoid arthritis (RA) on background non-biologic DMARDs who have an…
- Trial name
- NCT01245439
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 17 sites in Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis of the Knee
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan
The main purpose of this study is to evaluate the efficacy of the study drug known as duloxetine in participants with chronic osteoarthritis (OA) and knee pain in Japan.
- Trial name
- NCT02248480
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 354 people
- Sponsor
- Eli Lilly and Company
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