Clinical trials: Arthritis
Peripheral Neuropathies, Osteoarthritis
A Proof of Concept Study to Investigate the Effect of a New Treatment in Patient With Chronic Pain
The purpose of this clinical trial conducted in patients suffering from chronic pain is to study the relationship between individual patients' profile and their analgesic response
- Trial name
- NCT02459197
- Testing
- Heat Pain Stimuli A, Heat Pain Stimuli B, Positive Video
- Where
- 6 sites in Belgium, France
- Volunteers
- 114 people
- Sponsor
- Tools4Patient
Knee Osteoarthritis
Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis
The purpose of this study is to examine the effectiveness of standard physical therapy and an internet-based exercise program for people with knee osteoarthritis (OA).
- Trial name
- PATH-IN (NCT02312713)
- Testing
- Internet Based Exercise Training, Physical Therapy
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis of the Knee
Repeat Injection of Cingal® for Osteoarthritis of the Knee
The objective of this study is to evaluate the safety of an injection of Cingal® in subjects with Osteoarthritis (OA) of the knee who participated in Cingal 13-01, and who received either a Cingal, Monovisc, or saline injection…
- Trial name
- NCT02381652
- Testing
- Cingal
- Where
- 10 sites in Czechia, Hungary and 1 more
- Volunteers
- 242 people
- Sponsor
- Anika Therapeutics, Inc.
Ankylosing Spondylitis
An Observational, Retrospective, Multicenter, National Study for the Monitoring of Subjects Who Participated in the LoadET Clinical Trial
Previous studies suggest that an increase in doses of weekly etanercept from 50 mg to 100 mg improves the efficacy of the treatment in patients with cutaneous psoriasis, rheumatoid arthritis, and psoriatic arthritis.
- Trial name
- RELOADET (NCT01793285)
- Testing
- ETANERCEPT
- Where
- 15 sites in Spain
- Volunteers
- 85 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate
This randomized, double-blind, parallel-group study will evaluate the efficacy and safety of RoActemra/Actemra (tocilizumab) in combination with methotrexate versus RoActemra/Actemra monotherapy in patients with rheumatoid…
- Trial name
- NCT01399697
- Testing
- methotrexate, tocilizumab [RoActemra/Actemra]
- Where
- 54 sites in Spain
- Volunteers
- 261 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and Blood
Acupuncture is used and recommended by the WHO for the treatment of Rheumatoid Arthritis. The molecular bases of this recommendation are not known, the investigators want to compare with the usage of high-throughput molecular…
- Trial name
- NCT01619176
- Testing
- methotrexate, non-steroidal anti-inflammatory drug (NSAID), leflunomide
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Rheumatoid Arthritis
A Phase III Study of Abatacept in Japanese Subjects With Rheumatoid Arthritis
The purpose of this study is to demonstrate the safety of chronic use of abatacept in Japanese Subjects with Rheumatoid Arthritis (RA) having completed clinical studies IM101-071, IM101-034, and also Disease Modifying…
- Trial name
- NCT00484289
- Testing
- Abatacept
- Where
- 39 sites in Japan
- Volunteers
- 217 people
- Sponsor
- Bristol-Myers Squibb
Psoriatic Arthritis
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy
The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active psoriatic arthritis (PsA).
- Trial name
- KEEPsAKE 1 (NCT03675308)
- Testing
- Risankizumab
- Where
- 256 sites in United States, Argentina and 37 more
- Volunteers
- 964 people
- Sponsor
- AbbVie
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Psoriatic Arthritis
Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors
To examine the safety and efficacy of tofacitinib in subjects with active psoriatic arthritis who have previously had an inadequate response to at least one TNF inhibitor either due to lack of efficacy or an adverse event.
- Trial name
- OPAL BEYOND (NCT01882439)
- Testing
- Tofacitinib
- Where
- 125 sites in United States, Australia and 12 more
- Volunteers
- 395 people
- Sponsor
- Pfizer
Neck Pain, Chronic Pain
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
Given the modest effectiveness of current treatments and the burden chronic neck pain places on Veterans, the investigators' research proposal is significant in several regards.
- Conditions
- Neck Pain, Chronic Pain, Pain, Arthritis
- Trial name
- TOMCATT (NCT03100539)
- Testing
- Therapist treated massage, Care ally assisted massage
- Where
- United States
- Volunteers
- 395 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis of the Knee
Efficacy Study of an Unloading Brace for Knee Osteoarthritis
Subjects with symptomatic unicompartmental osteoarthritis of the knee will be invited to participate in this randomized study. Subjects will be assigned to either a Fusion Osteoarthritis Knee Brace group, or a control group that…
- Trial name
- NCT02150057
- Testing
- Breg Fusion Unloading Brace
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Andrews Research & Education Foundation
Arthritis, Rheumatoid
Methotrexate (Rheumatrex) High Dose Special Investigation (Regulatory Post Marketing Commitment Plan)
This Investigation is to be performed for the purpose of assessing the following information in the long-term post-marketing daily medical practice in the patients who receive REUMATOLEX 2 mg Capsule for the treatment of…
- Conditions
- Arthritis, Rheumatoid, High Dose
- Trial name
- NCT01414257
- Testing
- Methotrexate (MTX)
- Where
- Japan
- Volunteers
- 2,860 people
- Sponsor
- Pfizer
Psoriatic Arthritis
Safety and Efficacy Study of Apremilast to Treat Psoriatic Arthritis
The purpose of this study is to determine whether apremilast is safe and effective for treating patients with psoriatic arthritis.
- Trial name
- NCT01925768
- Testing
- Apremilast 30 mg
- Where
- 71 sites in United States, Australia and 8 more
- Volunteers
- 219 people
- Sponsor
- Amgen
Rheumatoid Arthritis
A Pharmacokinetic and Pharmacodynamic Study of MabThera (Rituximab) Plus Methotrexate in Patients With Rheumatoid Arthritis (RA)
This single arm study will investigate the pattern of B cell depletion in synovial tissue and peripheral blood of patients with active RA, after MabThera (1000mg iv x 2 on days 1 and 15) + methotrexate (10-25mg/week po)…
- Trial name
- NCT00422942
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Hoffmann-La Roche
Xerostomia, Sjogren Syndrome
Green Tea Lozenges for the Management of Dry Mouth
The goal of this proposal is to investigate the effectiveness of a Medical College of Georgia patent pending formulation of natural plant extracts on patients with xerostomia.
- Conditions
- Xerostomia, Sjogren Syndrome, Dry Mouth
- Trial name
- NCT01647737
- Testing
- MighTeaFlow, Xylitol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Spondylitis, Ankylosing, Arthritis, Rheumatoid
An Observational Study of Infliximab Injection in Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis Participants
The purpose of this observational study is to evaluate the safety and effectiveness of infliximab injection under actual conditions of use in participants, and to learn more about its adverse events.
- Conditions
- Spondylitis, Ankylosing, Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic
- Trial name
- NCT00760669
- Testing
- Infliximab; observational study, Methotrexate; observational study
- Volunteers
- 1,061 people
- Sponsor
- Janssen Korea, Ltd., Korea
Rheumatoid Arthritis
Abatacept With Methotrexate- Phase IIB
This study was conducted to assess the safety and tolerability of Abatacept combined with Methotrexate in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT00162266
- Testing
- Abatacept (BMS-188667)
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 524 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Safety and Effectiveness of Infliximab in Slovakia When Used for Rheumatoid Arthritis (Study P04741)(COMPLETED)
This study will gather information on the safety and efficacy of patients with rheumatoid arthritis (RA) who are starting treatment with infliximab for the first time.
- Trial name
- NCT00724243
- Testing
- Infliximab
- Volunteers
- 33 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
Phase IIIB Subcutaneous Missed Dose Study
The purpose of the study is to determine whether subcutaneous abatacept administered to patients with rheumatoid arthritis is associated with increased immunogenicity or increased safety events upon withdrawal and reintroduction.
- Trial name
- NCT00533897
- Testing
- Abatacept
- Where
- 27 sites in United States, Argentina and 3 more
- Volunteers
- 270 people
- Sponsor
- Bristol-Myers Squibb
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