Clinical trials: Arthritis
Osteoarthritis, Hip
Outcomes 8 Years After Minimal Invasive THA
There exists only limited scientific evidence concerning medium- to long-term benefits concerning minimally invasive (MI) total hip arthroplasty (THA).
- Trial name
- NCT03657953
- Testing
- surgical approach
- Where
- Germany
- Volunteers
- 157 people
- Sponsor
- Technische Universität Dresden
Rheumatoid Arthritis
Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis
The primary objective of this study was to evaluate the tolerability and safety of rituximab in combination with methotrexate (MTX) and etanercept or adalimumab in participants with active rheumatoid arthritis (RA).
- Trial name
- NCT00298272
- Testing
- IDEC-C2B8 (rituximab), Methotrexate, Etanercept
- Where
- 18 sites in United States
- Volunteers
- 54 people
- Sponsor
- Biogen
Osteoarthritis, Knee
Clinical Efficacy of Platelet-Rich Plasma and Hyaluronic Acid Versus Hyaluronic Acid for Knee Osteoarthritis With MRI Analysis
The study hypothesizes that the combination of Cellular Matrix PRP-HA is superior to Hyaluronic Acid (HA) alone, specifically from the Orthovisc Kit, in relieving pain and function associated with knee osteoarthritis.
- Trial name
- NCT06636695
- Testing
- Cellular Matrix, Orthovisc
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- Changi General Hospital
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Arthroscopic Debridement Followed by Intra-articular Injection of Micro-fragmented Adipose Tissue in Patients Affected by Knee Osteoarthritis
Background/Objectives: Micro-fragmented adipose tissue is emerging as a promising option for the treatment of various diseases including knee osteoarthritis (OA), though clinical trials are often limited by small sample size and…
- Trial name
- GemsforKnee (NCT06545266)
- Testing
- micro-fragmented adipose tissue injection
- Volunteers
- 41 people
- Sponsor
- Istituto Clinico Humanitas
Osteoarthritis of the Knee
A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis
A 4-week, Randomized, Double-blind, Multicenter, Placebo-controlled Phase 2 Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects with Osteoarthritis (OA) of the Knee
- Trial name
- HP-5000 (NCT03277066)
- Testing
- Diclofenac Sodium Active Topical Patch 1, Diclofenac Sodium Active Topical Patch 2
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Noven Pharmaceuticals, Inc.
Spondyloarthritis
Performance of EOS Imaging System in the Assessment of Spondyloarthritis Structural Changes Compared With Standard Radiography
Spondyloarthritis is a chronic rheumatic disease that requires prolonged radiographic follow-up. This repetitive exposure to ionizing radiation puts at risk the radiosensitive organs exposed in the field of irradiation.
- Trial name
- NCT03863756
- Testing
- EOS
- Where
- Tunisia
- Volunteers
- 75 people
- Sponsor
- Faculty of Medicine of Tunis
Osteoarthritis of the Knee
Triathlon PKR Study in Japan
The Purpose of this study is to evaluate compatibility of the Triathlon Partial Knee Replacement (PKR) with the Japanese population.
- Trial name
- NCT02552095
- Testing
- Triathlon PKR
- Where
- 5 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Stryker Japan K.K.
Rheumatoid Arthritis
Study of the Human Anti-TNF Monoclonal Antibody in Patients With Active Rheumatoid Arthritis
The primary objective of this study is to assess the safety (by collecting adverse events and serious adverse events) of adalimumab administered every other week to patients with moderately to severly active rheumatoid arthritis…
- Trial name
- CanAct (NCT00649545)
- Testing
- adalimumab
- Sponsor
- Abbott
Gout
A Clinical Trial of HEC93077 in Chinese Healthy Subjects and HUA Patients With Single or Multiple Dosing
A phase 1 clinical trial of HEC93077,to evaluate the safety ,PK,PD and food effect in Chinese healthy subjects and HUA patients after single or multiple dosing.
- Trial name
- NCT05127772
- Testing
- HEC93077
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Acupuncture, Knee Osteoarthritis
Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points
The investigators plan to investigate the effectiveness of acupuncture at highly sensitive points, compared with lowly/non-sensitive points or no acupuncture (waiting-list), in improving pain, joint function and quality of life…
- Conditions
- Acupuncture, Knee Osteoarthritis, Sensitive Acupoints, Tender Points
- Trial name
- NCT03299439
- Testing
- acupuncture
- Where
- 4 sites in China
- Volunteers
- 666 people
- Sponsor
- West China Hospital
Knee Osteoarthritis
Comparison Between Mobithron® and Crystalline Glucosamine Sulphate in Patients With Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disorder that causes pain, functional limitation, and reduced quality of life.
- Trial name
- NCT07717957
- Testing
- Mobithron®, Crystalline Glucosamine Sulphate
- Where
- Malaysia
- Volunteers
- 34 people
- Sponsor
- BREGO Life Sciences
Osteoarthritis
Clinical Study on BiHapro Total Hip System With Different Surface Coatings
This post market study intends to evaluate the safety and the performance of BiHapro Total Hip System with two types of coatings.
- Trial name
- NCT00755001
- Testing
- BiHapro hip stem with PPS Ti+Plasma HA, BiHapro hip stem with PPS Ti+BoneMaster HA
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Osteoarthritis, Knee
Post-market Follow up Study of the 'BPK-S Integration' UC as Primary Implant in the Variants CoCr or Ceramic
Prospective Post-Market Clinical Follow up study according to MEDDEV 2.12/2 rev2 of the European Union. Patients receiving the primary knee implant BPK-S UC as primary implant in either variant ceramic or CoCr (metal) are…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Joint Instability, Arthritis
- Trial name
- NCT03293719
- Testing
- BPK-S Integration UC
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Peter Brehm GmbH
Axial Spondyloarthritis, Ankylosing Spondylitis
A Study to Assess the Safety of Subcutaneous Secukinumab for Treatment in Adult Indian Participants With Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS), and Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
The aim of this study is to assess the safety of secukinumab in Indian adult participants with axSpA, AS, and nr-axSpA over a 16-week treatment period.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Non-Radiographic Axial Spondyloarthritis
- Trial name
- NCT07737730
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Osteoarthritis,Knee
Cryotherapy Associated With Exercise in Pain Control and Physical Function in Individuals With Knee Osteoarthritis
The purpose of this study is to verify the effect of cryotherapy associated with an exercise protocol in pain control, function and quality of life in individuals with knee osteoarthritis
- Trial name
- NCT03360500
- Testing
- EXERCISE PROTOCOL + CRYOTHERAPY, EXERCISE PROTOCOL
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal de Sao Carlos
Sjogren's Syndrome, Dry Eye
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
The objective of the present study was to evaluate the efficacy of autologous serum tears combined with 0.05% cyclosporin eye drop in treating Sjögren's syndrome dry eye and their effect on corneal nerves.
- Conditions
- Sjogren's Syndrome, Dry Eye, Ocular Surface Disease
- Trial name
- AST/SS (NCT06013436)
- Testing
- Autologous serum tears combined with 0.05% cyclosporin eye drop
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Rheumatoid Arthritis and Associated Conditions, Lung Diseases, Interstitial
Using Thoracic Ultrasound to Detect Interstitial Lung Disease in Patients With Rheumatoid Arthritis
Background: Pulmonary diseases are significant contributors to morbidity and mortality in patients with rheumatoid arthritis (RA). One of the most common pulmonary manifestation in RA is interstitial lung disease (RA-ILD).
- Trial name
- AURORA (NCT05396469)
- Testing
- National guideline treatment
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Torkell Ellingsen
Arthritis, Rheumatoid, Arthritis, Psoriatic
WORKWELL: Testing Work Advice for People With Arthritis
Background: Inflammatory arthritis (IA) causes work disability, absenteeism (sick leave) and presenteeism (reduced productivity) at high cost to individuals, employers and society.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Arthritis, Inflammatory
- Trial name
- WORKWELL (NCT03942783)
- Testing
- WORKWELL, Control
- Where
- 18 sites in United Kingdom
- Volunteers
- 249 people
- Sponsor
- University of Salford