Clinical trials: Arthritis (Knee)
Osteoarthritis, Knee
Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of intraarticular injection of Cell-free Stem Cell-derived Extract Formulation for treatment of knee osteoarthritis symptoms.
- Trial name
- NCT04971798
- Testing
- Cell-free Stem Cell-derived Extract Formulation (CCM)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- General Therapeutics
Osteoarthritis, Knee
Assess the Blood-Oxygen-Level-Dependent (BOLD) Signal Changes in the Brain by Paracetamol as Measured by Functional Magnetic Resonance Imaging (fMRI) in Subjects With Osteoarthritis (OA)
Blood-Oxygen-Level-Dependent (BOLD) responses to painful mechanical stimulation of the OA knee following treatment with four consecutive doses (at 8 hour intervals) on giving sustained released paracetamol treatment or placebo…
- Trial name
- NCT01105936
- Testing
- Paracetamol
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis of the Knee
Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthritis of the Knee
This is a randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of Intra-Articular (IA) verapamil in the treatment of joint pain in patients with knee osteoarthritis…
- Trial name
- NCT01645709
- Testing
- Verapamil
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Calosyn Pharma, Inc.
Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis(OA)
This 39-week, open label study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2360 study.
- Trial name
- NCT00475800
- Testing
- Lumiracoxib
- Where
- 6 sites in United States, Canada
- Volunteers
- 833 people
- Sponsor
- Novartis
Osteo Arthritis of the Knee
Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%
The objective of this study is to evaluate the clinical equivalence and safety of the Test formulation of diclofenac sodium topical gel 1% (Anchen Pharmaceuticals, Inc.) compared to the marketed formulation Voltaren® Gel…
- Trial name
- NCT01456611
- Testing
- Diclofenac
- Where
- 57 sites in United States
- Volunteers
- 749 people
- Sponsor
- Anchen Pharmaceuticals, Inc
Osteoarthritis, Knee
A Single Time-Point Study to Evaluate the ConforMIS iTotal (PS) Knee Replacement System Versus Off-the-Shelf
This study is designed to compare outcome data for patients who have recently undergone surgery with the iTotal® Posterior Stabilizing (PS) Knee Replacement System (hereafter referred to as the "iTotal") versus those who have…
- Trial name
- NCT03146819
- Testing
- iTotal PS Knee Replacement System, Off-the-Shelf Knee Replacement System
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Restor3D
Gonarthrosis
Management of Joint Pain Associated With Osteoarthritis of the Knee With Association of Plant Extracts.
The aim of the study is to evaluate at 3 months the effect of a supplementation with extracts of Curcuma longa, Boswellia serrata and Porphyra umbilicalis on the acceptability of pain for patients suffering from gonarthritic pain.
- Trial name
- NCT02977936
- Testing
- Cartimotil Fort
- Where
- France
- Volunteers
- 126 people
- Sponsor
- PiLeJe
Osteoarthritis
Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the efficacy of a single intraarticular dose of GZ389988 compared to placebo for relief of knee pain in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT02845271
- Testing
- GZ389988, acetaminophen or paracetamol, fixed combination of paracetamol + codeine
- Where
- 2 sites in Germany
- Volunteers
- 104 people
- Sponsor
- Genzyme, a Sanofi Company
Pain, Osteoarthritis, Hip
Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee
This clinical trial tests the pain relieving effectiveness of OROS hydromorphone, a once-daily formulation of a strong opioid against placebo in patients, who are suffering from pain due to osteoarthritis of the hip or the knee…
- Conditions
- Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT00980798
- Testing
- OROS hydromorphone HCl
- Where
- 12 sites in Czechia, Romania and 2 more
- Volunteers
- 288 people
- Sponsor
- Janssen-Cilag International NV
Osteoarthritis, Knee
A Study of the Efficacy and Safety of EUFLEXXA™ for Treatment of Painful Osteoarthritis of the Knee
This multicenter, randomized, double-blind study will be performed in approximately 600 subjects with chronic idiopathic osteoarthritis (OA) of the knee. An open-label safety extension will follow.
- Trial name
- NCT00379236
- Testing
- EUFLEXXA™
- Where
- United States
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Osteoarthritis, Knee
AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 4-week trial of a formulation of AMZ001 once or twice daily versus placebo twice daily, including a single-blind treatment group with a…
- Trial name
- NCT03691844
- Testing
- AMZ001, Comparator
- Where
- 7 sites in United States, Czechia and 1 more
- Volunteers
- 444 people
- Sponsor
- Amzell
Knee Osteoarthritis (OA)
A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis
This randomized, double-blind, placebo-controlled clinical study evaluates the efficacy of Native CT-II® (undenatured type II collagen) in individuals with knee osteoarthritis using a parallel design.Participants are assigned to…
- Trial name
- NCT06917287
- Testing
- Native CT-II® (undenatured type II collagen), Glucosamine HCL + Chondroitin Sulphate (G+C) [Comparator]
- Where
- 5 sites in India
- Volunteers
- 114 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis of the Knee
To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee
This is a randomized, double-blind study to compare the efficacy and safety of LAYLA tablet and CENATONE tablet in the treatment of osteoarthritis of the knee.
- Trial name
- NCT02049606
- Testing
- LAYLA tablet, CENATONE tablet
- Where
- 6 sites in South Korea
- Volunteers
- 134 people
- Sponsor
- PMG Pharm Co., Ltd
Degenerative Osteoarthritis, Rheumatoid Arthritis
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
Prospective, multinational pilot study for evaluation of the Pheno4U data platform in Total Knee Arthroplasty (TKA) patients
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Posttraumatic Arthropathy, Chronic Instability of Knee
- Trial name
- Pheno4U Pilot (NCT05302934)
- Testing
- Pheno4U
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 600 people
- Sponsor
- Aesculap AG
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Osteoarthritis, Knee
A Multicenter Prospective Randomized Control Study on Persona Total Knee System vs NexGen
A multicenter, prospective randomized controlled trial comparing the Persona knee system to the Nexgen knee system in total knee arthroplasty.
- Trial name
- NCT03073941
- Testing
- Persona total knee system, Nexgen total knee system
- Where
- 5 sites in Denmark
- Volunteers
- 332 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Rheumatoid Arthritis
Robotic Arm Assisted Total Knee Arthroplasty
The Investigation will be conducted as a single-submission, multi-center study with approval from and in compliance of the Western Institutional Review Board (WIRB).
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT02058069
- Testing
- Robotic Arm Assisted Total Knee Arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- MAKO Surgical Corp.
Osteoarthritis, Psoriasis
Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis
The purpouse of this study is to determine the efficacy and safety of chondroitin sulphate conventional treatment in patients with both knee osteoarthritis and plaque psoriasis.
- Conditions
- Osteoarthritis, Psoriasis, Joint Diseases, Muskuloskeletal Diseases
- Trial name
- NCT00669123
- Testing
- Chondroitin sulphate
- Where
- 2 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Bioiberica
Osteoarthritis
A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee Osteoarthritis
This study is a phase 2, 52-week international, multi-regional, multi-center, randomized, double-blind, placebo-controlled dose-ranging study for the treatment of osteoarthritis.
- Trial name
- Roccella (NCT03595618)
- Testing
- GLPG1972
- Where
- 44 sites in United States
- Volunteers
- 932 people
- Sponsor
- Lakefront Biotherapeutics NV
Osteoarthritis
Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the analgesic efficacy and safety of tanezumab added on to diclofenac SR in patients with osteoarthritis of the knee or hip currently experiencing partial benefit from, and are…
- Trial name
- NCT00864097
- Testing
- tanezumab, diclofenac
- Where
- 77 sites in Austria, France and 8 more
- Volunteers
- 607 people
- Sponsor
- Pfizer
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