Clinical trials: Arthritis (Knee)
Osteoarthritis
Prospective, Multiconfiguration Study to Assess Functional Performance of Primary Total Knee Arthroplasty System
This post-marketing investigation will evaluate the functional knee performance of Subjects who have undergone primary total knee arthroplasty (TKA).
- Trial name
- 10004 (NCT01746524)
- Testing
- ATTUNE Primary Total Knee Arthroplasty
- Where
- 20 sites in United States, Australia and 2 more
- Volunteers
- 1,138 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
- Trial name
- NCT06000410
- Testing
- Amniotic Suspension Allograft
- Where
- 41 sites in United States
- Volunteers
- 594 people
- Sponsor
- Organogenesis
Osteoarthritis, Knee
P.F.C. Sigma Fixed Versus P.F.C. RP Mobile Bearing Total Knee Systems
This post-market clinical follow-up study was designed to compile long-term knee replacement outcomes of the PFC Sigma fixed and PFC Sigma mobile Rotating Platform (RP) knee systems.
- Trial name
- NCT00208286
- Testing
- PFC Sigma Fixed Bearing, PFC Sigma Mobile Bearing
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- DePuy International
Osteoarthritis, Pain Assessment
A Study to Evaluate the Effectiveness and Safety of Multiple Doses of Tapentadol(CG5503) in Patients Awaiting Joint Replacement Surgery
The purpose of this study is to evaluate in patients who are eligible for elective primary total or partial joint replacement of the hip or knee due to chronic osteoarthritis the efficacy (level of pain control) of CG5503 over 5…
- Conditions
- Osteoarthritis, Pain Assessment, Arthralgia
- Trial name
- NCT00361582
- Testing
- CG5503 IR; tapentadol
- Volunteers
- 669 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteo Arthritis Knee
A Multicentre Clinical Investigation to Assess Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Chondroitin Sulfate in Knee Osteoarthritis
This is a multicentre, prospective, sponsor initiated clinical investigation that aims to evaluate safety and efficacy of Hyaluronic Acid Combined With Chondroitin Sulfate in symptomatic patients with OA of the knee.
- Trial name
- NCT04358120
- Testing
- Hyaluronic Acid Combined With Chondroitin Sulfate
- Where
- 5 sites in Czechia
- Volunteers
- 74 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis, Knee
Pilot Study of Lidocaine 5% Patch Versus Placebo in Patients With Osteoarthritis Pain of the Knee
Patients with unilateral or bilateral osteoarthritis (OA) of the knee participated in a Phase II clinical trial to assess the efficacy of lidocaine 5% patch compared with placebo in the treatment of pain from OA of the knee.
- Trial name
- NCT00904462
- Testing
- Lidoderm
- Where
- 24 sites in United States
- Volunteers
- 224 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Osteoarthritis of the Knee
Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis
The purpose of this study is to compare efficacy and safety of intra-articular LBSA0103 once versus intra-articular hyaluronic acid injections (Hyruan Plus Injection) once weekly for 3 weeks in the treatment of patients with…
- Trial name
- NCT01510535
- Testing
- Hyruan Plus, LBSA0103
- Where
- South Korea
- Volunteers
- 287 people
- Sponsor
- LG Life Sciences
Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease
PMCF Study on the Safety, Performance and Clinical Benefits Data of the NexGen TM Augmentation Patella
The study is a single-center, retrospective and prospective, non-randomized, non-controlled and consecutive series post-market study.
- Conditions
- Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease, Functional Deformity, Revision Total Knee Arthroplasty
- Trial name
- NCT05253976
- Where
- Switzerland
- Sponsor
- Zimmer Biomet
Osteoarthritis
Study of Safety and Efficacy of 6 mL Synvisc-One (Hylan G-F 20) in Indian Patients With Symptomatic Osteoarthritis of Knee(s) After Initial and Repeat Treatment
Primary Objective: To evaluate the safety and efficacy of a single 6 mL intraarticular (IA) injection of Synvisc-One in participants in India with symptomatic osteoarthritis (OA) of the knee(s).
- Trial name
- OASIS (NCT02389452)
- Testing
- Synvisc-One
- Volunteers
- 394 people
- Sponsor
- Genzyme, a Sanofi Company
Osteoarthritis
Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee
An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in patients who have pain associated with osteoarthritis of the knee despite…
- Trial name
- NCT05377489
- Testing
- RTX-GRT7039
- Where
- 96 sites in United States, Bulgaria and 5 more
- Volunteers
- 714 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis (OA) of the Knee
A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee
The goal of this clinical trial is to learn if a single knee injection of different doses (Dose A and Dose B) of an investigation product PCRX-201, following steroid pretreatment, is safe and tolerable in male of female patients…
- Trial name
- NCT06884865
- Testing
- Enekinragene Inzadenovec (PCRX-201)
- Where
- 40 sites in United States
- Volunteers
- 135 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee, Pain
Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis (OA) of the Knee
The primary objective of this study is to evaluate the analgesic efficacy of 2 dose levels of V116517 versus placebo.
- Trial name
- NCT01688934
- Testing
- V116517 50-mg tablets, V116517 30-mg tablets, Naproxen 500-mg capsules
- Where
- 18 sites in United States
- Volunteers
- 230 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Knee, Osteoarthritis, Hip
Open Label Safety and Tolerability Study of COV155 in Subjects With Osteoarthritis (OA) or Chronic Low Back Pain (CLBP)
A study to show the safety of COV155 in patients with osteoarthritis of the knee or hip or moderate to severe chronic low back pain.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Low Back Pain
- Trial name
- NCT01722864
- Testing
- COV155
- Where
- 34 sites in United States
- Volunteers
- 153 people
- Sponsor
- Mallinckrodt
Knee Osteoarthritis
Innovations in Genicular Outcomes Registry
The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA.
- Trial name
- iGOR (NCT05495334)
- Testing
- Treatment for Knee OA
- Where
- 19 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis of the Knee
Hydros and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis
The purpose of this study is to evaluate the safety and efficacy of Hydros-TA Joint Therapy for relief of pain due to OA of the knee.
- Trial name
- NCT02022930
- Testing
- Hydros, Hydros-TA, Triamcinolone Acetonide
- Where
- 5 sites in Australia, Canada and 1 more
- Volunteers
- 510 people
- Sponsor
- Carbylan Therapeutics, Inc.
Knee Osteoarthritis
Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis
To evaluate the clinical efficacy and safety of dental pulp mesenchymal stem cells in the treatment of primary mild to moderate knee osteoarthritis through a comparative study with sodium hyaluronate.
- Trial name
- NCT04130100
- Testing
- Low Dose of Mesenchymal stem cell, High Dose of Mesenchymal stem cell, Sodium Hyaluronate
- Where
- China
- Volunteers
- 60 people
- Sponsor
- CAR-T (Shanghai) Biotechnology Co., Ltd.
Osteoarthritis, Knee, Pain
New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis
Prospective, multicenter study, unmasked, single-arm, to study the safety and efficacy of a new hydroxyethyl cellulose hydrogel for the treatment of the knee pain caused by osteoarthritis.
- Trial name
- PROMGEL-OA (NCT04061733)
- Testing
- Hydrogel injection
- Where
- 3 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Promedon
Osteoarthritis, Knee Pain Arthritis
Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage
This clinical trial aims to evaluate and compare the efficacy and safety of CartiPRO, an approved intra-articular atelocollagen injection, versus Synovian injection for the relief of knee pain in patients with knee…
- Conditions
- Osteoarthritis, Knee Pain Arthritis, Cartilage Defects of the Knee, Knee Osteoarthritis
- Trial name
- NCT07267793
- Testing
- CartiPRO, Synovian®
- Where
- 5 sites in South Korea
- Volunteers
- 194 people
- Sponsor
- DALIM TISSEN Co., Ltd.
Knee Arthropathy
Persona Cohort Nordic Multicenter Study
In this project the investigators wish to: Evaluate intra-operative and postop complications, longer term survivorship and patient reported outcome measures (PROMs) following primary total knee replacement using Persona Total…
- Trial name
- NCT03495232
- Testing
- Zimmer Biomet Persona total knee system
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 700 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Hip, Osteoarthritis, Knee
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
The purpose of this study is to evaluate the safety profile of tapentadol (CG5503) PR at doses of 100 mg - 250 mg administered twice daily over a maximum one year period to patients with at least a 3-month history of low back…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Lower Back Pain, Pain
- Trial name
- NCT00361504
- Testing
- Oxycodone CR, Tapentadol (CG5503) ER
- Where
- 52 sites in United States, Canada
- Volunteers
- 1,123 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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