Clinical trials: Arthritis (Knee)
Osteoarthritis
Resistive Exercise for Arthritic Cartilage Health (REACH)
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group.
- Trial name
- NCT00465660
- Testing
- Progressive resistance training
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Knee Arthritis, Osteoarthritis
Platelet-Rich Plasma Composition and Clinical Effects in Knee Osteoarthritis
This is a prospective, observational cohort study involving 40 patients with primary knee osteoarthritis hospitalized in a rehabilitation hospital in Cluj-Napoca.
- Trial name
- NCT07558980
- Testing
- intra-articular administration of plasma rich in platelets (PRP)
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Knee Osteoarthritis
Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis
The goal of this Phase II/III, double-blinded, multicenter clinical trial is to assess the clinical efficacy of autologous peripheral blood mononuclear cells (PBMCs) in the management of knee osteoarthritis (KOA).
- Trial name
- PBMC-KOA (NCT07703280)
- Testing
- High-dose PCP-PBMCs injection, Solu-Medrol, Low-dose PCP-PBMCs injection
- Where
- 4 sites in Taiwan
- Volunteers
- 240 people
- Sponsor
- DuoGenic StemCells Corporation (DGSC)
Osteoarthritis of Knee
Clinical Efficacy and Safety of NEOIAL HC for Intra-articular Use in the Treatment of Severe Knee Osteoarthritis
Osteoarthritis (OA) is one of the most frequent causes of pain and disability in adults. According to the Osteoarthritis Research Society International (OARSI), at least 40% of people over the age of 65 suffer from symptomatic…
- Trial name
- NCT05936762
- Testing
- Neoial HC
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nextrasearch S.r.l.s.
Osteoarthritis, Knee
A Comparative Analysis of Two Types of Exercise on Outcomes Following Total Knee Arthroplasty
The purpose of this study was to compare the effects of two exercise programs, using low velocity (LV) and high velocity (HV) contractions, on outcomes of individuals who have undergone total knee arthroplasty (TKA).
- Trial name
- NCT01545986
- Testing
- Exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Helen Hayes Hospital
Osteoarthritis, Knee
CBD for Knee Osteoarthritis
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population.
- Trial name
- SLACK-OA (NCT06414473)
- Testing
- Cannabidiol (CBD) Extract
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Knee Osteoarthritis
Long-Term Follow-Up Study of Patients With Osteoarthritis of the Knee Treated With UBX0101 or Placebo
A follow-up study to assess the long-term safety of intra-articular (IA) administration of UBX0101 in patients with painful knee osteoarthritis (OA).
- Trial name
- NCT04349956
- Where
- 17 sites in United States
- Volunteers
- 161 people
- Sponsor
- Unity Biotechnology, Inc.
Arthritis of Knee
Blood Levels of Local Anaesthetic in Knee Arthroplasty
The primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee replacement surgery.
- Trial name
- BLOCKS (NCT01873313)
- Testing
- Ropivacaine
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Knee Osteoarthritis
Electro-acupuncture in Knee Osteoarthritis
Knee osteoarthritis (KOA) is one of the most common musculoskeletal diseases in clinic. It usually occurs in middle-aged people, especially women. An estimated lifetime risk for KOA is approximately 40% in men and 47% in women.
- Trial name
- NCT03359603
- Testing
- Electro-acupuncture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ping Zhou
Musculoskeletal Diseases, Osteoarthritis, Knee
Effect of Research Participation Versus Usual Clinical Treatment on Pain in Patients With Musculoskeletal Disorders
This study explores the effects on pain, function and illness perceptions, of participating in clinical research versus being treated with standard care in patients with musculoskeletal disorders.
- Conditions
- Musculoskeletal Diseases, Osteoarthritis, Knee, Illness Perceptions
- Trial name
- NCT03785561
- Testing
- participation in a health research study
- Where
- Denmark
- Volunteers
- 1,850 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis, Knee
Prospective Randomized Study of Cementless vs Cemented UKA
To evaluate the non-inferiority of the cementless Engage Partial Knee System compared to cemented Engage Partial knee System.
- Trial name
- NCT05377450
- Testing
- Engage Partial Knee
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- JIS Research Institute
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
Ultrasound Therapy; Complications, Septic Arthritis
Exploratory Study of Ultrasound Signs of Native Septic Arthritis of the Knee
Primary objective: Description of ultrasound abnormalities seen in native septic arthritis of the knee during each visit. Primary endpoint: Describe the ultrasound abnormalities observed on Day 0, Day 10, 6 weeks, 3 months, 6…
- Conditions
- Ultrasound Therapy; Complications, Septic Arthritis, Knee Arthritis
- Trial name
- USAK (NCT04952220)
- Testing
- ultrasound
- Where
- 7 sites in France
- Volunteers
- 30 people
- Sponsor
- Poitiers University Hospital
Knee Osteoarthritis
RSA of the ATTUNE Knee System: RCT Comparing Traditional Vs Enhanced-Fixation Device Designs
The principal objective of this study is to compare migration patterns between the Attune and Attune S+ PS knee systems using model-based RSA over the first 2 post-operative years.
- Trial name
- NCT03554720
- Testing
- ATTUNE PS Knee, ATTUNE S+ PS Knee
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Osteoarthritis of the Knee
Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee
The objective of this trial is to evaluate the effect of Aquamin F versus placebo on NSAID (non-steroidal anti-inflammatory drug) dose reduction in subjects with osteoarthritis of the knee.
- Trial name
- NCT00755482
- Testing
- Aquamin F
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Marigot Ltd.
Osteoarthritis, Knee
Bayer OA Knee Pain Pilot
The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis.
- Trial name
- NCT05349682
- Testing
- dynamic contrast enhanced MRI, geniculate artery embolization
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Osteoarthritis, Knee
Oral Steroid Taper After Total Knee Arthroplasty
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
- Trial name
- NCT07070882
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Columbia University
Osteoarthritis, Total Knee Arthroplasty
Tourniquet and Quadricepsforce
The purpose for this study is to investigate the quadriceps (thigh) function preoperatively and 48 hours postoperatively during knee arthroplasty (total replacement of the knee joint) in a randomised study with or without the use…
- Trial name
- NCT01808859
- Testing
- Tourniquet
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Region Skane
Knee Osteoarthritis
Geniculate Artery Embolization for Knee Osteoarthritis
The purpose of this study is to perform a prospective case series to determine efficacy of transcatheter arterial embolization in treating knee osteoarthritis related pain, improving functionality, and reducing opiate usage in…
- Trial name
- GAE (NCT04951479)
- Testing
- Gel-Bead embolization
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Anish Ghodadra
Osteo Arthritis Knee
Intermittent Hypoxia-Hyperoxia Combined With Physical Therapy for Knee Osteoarthritis
This randomized controlled trial aims to evaluate the effectiveness of combining intermittent hypoxia-hyperoxia therapy (IHHT) with conventional physical therapy in improving pain, function, gait, balance, and general health…
- Trial name
- NCT06965946
- Testing
- Intermittent Hypoxia-Hyperoxia Therapy (IHHT), Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Medical University Peshawar