Clinical trials: Arthritis Knee
Mesenchymal Stem Cells, Knee Osteoarthritis
Cell Therapy With Cellistem-OA for Symptomatic Knee Osteoarthritis
Symptomatic knee osteoarthritis is a serious public health problem in the world, it carries a high personal, social and economic impact. Currently, there are no drugs that modify the natural course of the disease.
- Conditions
- Mesenchymal Stem Cells, Knee Osteoarthritis, Cell Therapy
- Trial name
- NCT04863183
- Testing
- CELLISTEM-OA, Triamcinolone acetonide
- Volunteers
- 30 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Osteoarthritis, Knee
Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
The aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (PS) rotating-platform mobile-bearing (RP-MB) total knee arthroplasty.
- Trial name
- NCT00954954
- Testing
- Standard PS RP-MB (P.F.C Sigma Rotating Platform knee), High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
- Where
- South Korea
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Knee, Pain
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol HCl / Contramid® Tablets to Twice Daily Tramadol HCl (SR) for the Treatment of Osteoarthritis of the Knee
A randomised, multi-centre, double-blind, double dummy, two arm parallel design study to compare the efficacy, safety, and clinical benefit of the test and reference product after treatment for 84 days in patients with…
- Trial name
- NCT00950651
- Testing
- Tramadol HCl Contramid® Once A Day, Tramadol HCl Twice a day
- Volunteers
- 431 people
- Sponsor
- Labopharm Inc.
Osteoarthritis
Effects of Therapeutic Exercises in Elderly Women With Knee Osteoarthritis
Knee Osteoarthritis is a degenerative disease associated with muscle weakness, arthralgia, rigidity and postural instability. Therapeutic exercise can reduce pain and improve muscle strength and postural balance, however benefits…
- Trial name
- TherExercOA (NCT02560831)
- Testing
- Therapeutic exercise and Pompage, Educational lectures
- Volunteers
- 22 people
- Sponsor
- Universidade Federal de Pernambuco
Osteoarthritis of the Knee
Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee
The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.
- Trial name
- MRC Knee (NCT00562822)
- Testing
- Arthroscopic surgery, Physical and medical therapy
- Where
- Canada
- Volunteers
- 188 people
- Sponsor
- University of Western Ontario, Canada
Osteoarthritis of Knee
Clinical Efficacy and Safety of NEOIAL HC for Intra-articular Use in the Treatment of Severe Knee Osteoarthritis
Osteoarthritis (OA) is one of the most frequent causes of pain and disability in adults. According to the Osteoarthritis Research Society International (OARSI), at least 40% of people over the age of 65 suffer from symptomatic…
- Trial name
- NCT05936762
- Testing
- Neoial HC
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nextrasearch S.r.l.s.
Osteoarthritis, Knee, Osteoarthritis, Hip
Effects of a Structured Digital Osteoarthritis Self-management Program After 6 Months of Adherence
This is a study based on a cohort in a register of patients enrolled in a digital osteoarthritis self-management program, Joint Academy.
- Trial name
- NCT04049318
- Testing
- Education+ exercise (delivered digitally)
- Where
- Sweden
- Volunteers
- 1,709 people
- Sponsor
- Lund University
Osteoarthritis, Knee
Comparison of Outpatient and Inpatient Spa Therapy
In this study, we aimed to compare the effectiveness of inpatient and outpatient physical therapy modalities and spa combination treatments on pain and functional status in patients with knee osteoarthritis.
- Trial name
- NCT04531969
- Testing
- Spa therapy and conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Abant Izzet Baysal University
Knee Osteoarthritis
The Effectiveness of Ultrasound Guided Ozone (O2-O3) Injection With Knee Osteoarthritis
Knee ostheoarthritis (KOA) is a common disabling and degenerative disease leading to painful joints, articular stiffness, and decreased function.
- Trial name
- NCT04830423
- Testing
- Medical ozone injection, steroid injection group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Osteoarthritis, Knee
Adductor Canal Block Combined With Local Infiltration Analgesia vs Local Infiltration Analgesia Alone for Postoperative Pain in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery.
- Trial name
- ADB_01 (NCT07517159)
- Testing
- Adductor Canal block, Local Infiltration Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Ankara University
Osteoarthritis of the Knee
Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee
The purpose of this study was to assess the safety and efficacy of FX006 for the treatment of pain in patients with osteoarthritis of the knee.
- Trial name
- NCT02357459
- Testing
- FX006, TCA IR 40
- Where
- 38 sites in United States, Australia and 6 more
- Volunteers
- 486 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Arthritis, Knee Osteoarthritis
Stated-Preferences in Knee Arthroplasty
The primary objectives of this study are to apply best-practice stated-preference methods to quantify patient preferences for benefit-risk tradeoffs associated with arthroplasty treatment options for end-stage osteoarthritis of…
- Conditions
- Arthritis, Knee Osteoarthritis, Arthropathy of Knee
- Trial name
- NCT03058380
- Testing
- Stated-Preferences Evaluation Instrument
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Duke University
Stroke
Strain Counterstrain and Muscle Energy Technique in Patients of Knee Osteoarthritis
This study aimed to evaluate the comparative effects of Strain Counterstrain (SCS) and Muscle Energy Technique (MET) on pain, range of motion (ROM), and functional disability in patients with knee osteoarthritis (KOA).
- Trial name
- NCT07066670
- Testing
- Strain Counterstrain with Routine Physical Therapy, Muscle Energy Technique with Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- University of Lahore
Knee Osteoarthritis, Anterior Cruciate Ligament Injury
Protective Role of Muscle Function for Early Features of Knee Osteoarthritis After Anterior Cruciate Ligament Injury
In this longitudinal prospective cohort study including young people with anterior cruciate ligament reconstruction (ACLR), the aims are to 1) study the association between different measures of muscle function and early future…
- Conditions
- Knee Osteoarthritis, Anterior Cruciate Ligament Injury, Osteoarthritis, Knee, Muscle Weakness
- Trial name
- SHIELD (NCT03473873)
- Testing
- Measures of muscle function
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 106 people
- Sponsor
- Lund University
Osteoarthritis, Knee
A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain
The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain. The study drugs will be given as an injection under the skin and as an oral capsule.
- Trial name
- NCT02192190
- Testing
- LY2951742, Celecoxib
- Where
- 38 sites in United States
- Volunteers
- 268 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
Benefits of Spa Therapy in Saint-Lary Soulan for Knee Osteoarthritis
The hypothesis is that the use of spa therapy in Saint-Lary Soulan for knee osteoarthritis treatment would have a therapeutic effect on this pathology.
- Trial name
- LARYTHERM (NCT05790824)
- Testing
- Spa therapy
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University of Bordeaux
Knee Pain Chronic, Osteoarthritis
Persona Ti-Nidium Post-Market Clinical Follow-up
The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- TKA (NCT04817969)
- Testing
- Zimmer Biomet Persona Ti-Nidium Total Knee System
- Where
- 7 sites in United States
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Remote and In-person Supervised Exercise in Patients With Knee Osteoarthritis
Exercise supervision via telehealth resources is an alternative to the in-person modality with similar therapeutic effectiveness across different clinical profiles.
- Trial name
- RISE-KOA (NCT06101797)
- Testing
- Remote supervised exercise group, In-person supervised exercise group
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Federal University of Pelotas
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Knee Osteoarthritis, Pain
Virtual Reality in Patients With Knee Osteoarthritis
One of the main challenges facing the therapist in the treatment of adhesive capsulitis is to motivate the patient throughout conventional therapy.
- Conditions
- Knee Osteoarthritis, Pain, Quality of Life
- Trial name
- NCT06272825
- Testing
- Virtual reality, conventional rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kirsehir Ahi Evran Universitesi