Clinical trials: Arthritis of Knee
Knee Osteoarthritis, Knee Arthritis
Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy
This is a randomized control trial to determine if there is a measurable change in voluntary quadriceps activation, RTD, pain, and function before and after a single session of manual physical therapy.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity
- Trial name
- NCT04234282
- Testing
- Manual Physical Therapy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jennifer Moreno Clinic
Ankle Osteoarthritis, Knee Osteoarthritis
Gait Asymmetry Assessed Using Portable Gait Analysis System
To date, detailed analysis of movement patterns in orthopaedic conditions are mainly performed in research projects. Because these tests are time consuming, they are not feasible in clinical routine or in standard examinations.
- Conditions
- Ankle Osteoarthritis, Knee Osteoarthritis, Hip Osteoarthritis, Lumbar Spine Stenosis
- Trial name
- Asymmetry (NCT02489188)
- Testing
- arthroplasty, manual therapy, lumbar spinal stenosis decompression
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Osteoarthritis, Knee
The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01)
Aim of EFEX-OA-01: To explore how running, cycling and resting acutely influence levels of collagen and proteoglycan in patients with osteoarthritis knee and in young healthy subjects, as reflected by changes in serum and urine…
- Trial name
- EFEX-OA-01 (NCT04542655)
- Testing
- Ergometer Cycling followed by treadmill running, Treadmill Running followed by ergometer cycling, Rest
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nordic Bioscience A/S
Knee Osteoarthritis, Elasticity Imaging Techniques
Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis
Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation.
- Trial name
- NCT05439317
- Where
- Taiwan
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Knee Osteoarthritis
Follow-up of Osteo-articular Biomarkers After Spa Therapy in a Population With Knee Osteoarthritis and Their Correlation With the Clinical Evolution
Spa therapy is used in the treatment of various diseases and mainly osteoarthritis. Knee osteoarthritis is a very common rheumatic disease whose prevalence increases with longer life span and is a public health problem.
- Trial name
- BIOMARTHROSE (NCT04308369)
- Testing
- Blood collection arm
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- CHI MONT DE MARSAN ET PAYS DES SOURCES
Knee Osteoarthritis
Treatment of Knee Osteoarthritis (KOA) by Injection of Autologous Adipose-derived Vascular Matrix Components (SVF) Into Joint Cavity
The purpose of this study was to analyze and study the efficacy and safety of autologous adipose-derived vascular matrix components (SVF) in patients with knee osteoarthritis before and after treatment through clinical…
- Trial name
- NCT06109220
- Testing
- Stromal vascular fraction,SVF
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Osteoarthritis, Knee
Evaluation Effect of Crocina on The Cellular Immune Responses in Osteoarthritis Patients
The effect of Crocina on the production of IL-4, IL-1 bet, IL-17, IL-10 and TGF-beta: The effect of crocina on gene expression of transcription factors T-bet, GATA-3.
- Trial name
- NCT03375814
- Testing
- Crocin
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Osteoarthritis, Knee
Compressive Myofascial Release in Knee Osteoarthritis
The purpose of the study is to compare the effects of compressive myofascial release and conventional knee osteoarthritis treatment to correct lateral patellar tracking.
- Trial name
- NCT05052593
- Testing
- compressive myofascial release, conventional treatment group
- Where
- 2 sites in Pakistan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Knee Arthritis Osteoarthritis
Knee Osteoarthritis Rehab: High-Intensity Laser vs Classical Modalities
This study aims to compare the effectiveness and safety of High-Intensity Laser Therapy (HILT) with conventional physical therapy treatments in patients with knee osteoarthritis.
- Trial name
- HILT-CM (KOA) (NCT07551245)
- Testing
- High-Intensity Laser Therapy (HILT), Conventional Physical Therapy Modalities
- Where
- Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Erbil Polytechnic University
Knee Osteoarthritis, Symptomatic Knee Osteoarthritis
Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis
The purpose of this study is to asses the efficacy of a 4 week low-intensity resistance training program with concurrent application of partial blood flow restriction (PBFR) to the exercising limbs to improve quadriceps strength…
- Trial name
- PBFR2 (NCT01440972)
- Testing
- partial blood flow restriction (PBFR), low intensity resistance training
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteoarthritis, Knee
Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee
This is a multicenter, randomized, double-blinded, parallel, placebo-controlled, phase I/IIa clinical trial of YYD302 for treatment of osteoarthritis of the knee.
- Trial name
- NCT02965495
- Testing
- YYD302 2ml, YYD302 3ml
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis
Brief Summary: Knee osteoarthritis (OA) is a common, disabling condition affecting the weight-bearing knee joint, leading to pain, reduced function, and muscle weakness, particularly of the quadriceps.
- Trial name
- NCT07308470
- Testing
- Etodolac-Loaded Solid Lipid Nanoparticle Gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Osteoporosis, Postmenopausal, Osteoarthritis, Knee
The Effect of High Impact Exercise on Bone and Articular Cartilage in Post-menopausal Women
Osteoarthritis (OA) and osteoporosis (OP) affect large numbers of the population. Around 8 million people in the UK are affected by OA and over 300,000 people present with fragility fractures in the UK each year.
- Conditions
- Osteoporosis, Postmenopausal, Osteoarthritis, Knee, BMD
- Trial name
- NCT03225703
- Testing
- Hopping
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoarthritis of the Knee
Irritation and Sensitization Study of HP-5000 Topical System
This study will assess skin irritation and sensitization for HP-5000 patch in healthy subjects.
- Trial name
- NCT04882319
- Testing
- HP-5000 Topical Patch, Saline Patch
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Noven Pharmaceuticals, Inc.
Knee Osteoarthritis, Knee Arthritis
Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty
Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT03302832
- Testing
- Physical Therapy, In-home Exercise Equipment
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Osteoarthritis, Accuracy of Intraarticular Needle Placement
Evaluation of the Medial Parapatellar Knee Injection Technique
The goal of our study is to present important anatomic considerations which should be considered before knee injection is performed.
- Trial name
- NCT00712972
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Pain, Inflammatory
A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement (TE) Study of GSK3858279 in Healthy Participants and Evaluation of the Efficacy of Repeat Doses in Participants With Osteoarthritis (OA)
This study is the first administration of GSK3858279 in humans and will be conducted in two parts: Part A will consist of a single ascending dose escalation design to evaluate safety, tolerability, PK, TE and immunogenicity of…
- Trial name
- NCT03485365
- Testing
- GSK3858279 IV, GSK3858279 SC
- Where
- 5 sites in Germany, Poland and 1 more
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Metabolic Syndrome, Meniscus Lesion
Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function
Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis.
- Conditions
- Metabolic Syndrome, Meniscus Lesion, Obesity, Abdominal, Knee Arthritis
- Trial name
- NCT04921202
- Testing
- Metabolic syndrome and meniscus injuries
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The First People's Hospital of Jingzhou
Osteoarthritis, Knee, Osteoarthritis
The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis
Static imaging has been commonly and clinically accepted to assess the severity of medial knee osteoarthritis (KOA), especially the radiography.
- Trial name
- NCT02878239
- Testing
- Steps 1, Steps 2
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command