Clinical trials: Arthritis of the Knee
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
Evaluation of the Efficacy and Safety of Nise 100 mg in the Management of Osteoarthrosis (Gonarthrosis)
Study is conducted to evaluate safety and efficacy in patients with osteoarthritis
- Trial name
- NISE-2013 (NCT02922712)
- Testing
- NISE
- Volunteers
- 202 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Osteoarthritis Knee
Integrated Treatment Program for Osteoarthritis of the Knee
The purpose of this study is to determine the ability to assimilate and implement an integrated treatment program osteoarthritis of the knee, including the diagnosis and follow-up by a family physician in primary care clinics…
- Trial name
- NCT02200107
- Testing
- self management education
- Where
- Israel
- Volunteers
- 155 people
- Sponsor
- Meir Medical Center
Osteoarthritis, Hip, Osteoarthritis, Knee
A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee
The study schedule consists of a Screening Period (up to 14 days), a blinded 4- week Titration-to-Effect Period with weekly visits, a blinded 4-week Maintenance Treatment Period at the optimal dose level determined for each…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Arthritis, Joint Diseases
- Trial name
- NCT02944448
- Testing
- CR845 tablet 1 mg, CR845 tablet 2.5 mg, CR845 tablet 5 mg
- Where
- 35 sites in United States
- Volunteers
- 761 people
- Sponsor
- Cara Therapeutics, Inc.
Knee Osteoarthritis, Hyaluronic Acid
Evaluate the Safety and Effectiveness of Mannitol-combined Hyaluronan Supplement in the Treatment of Knee OA
To evaluate the effectiveness and safety of JETKNEE Synovial Fluid Supplement for alleviating pain of knee osteoarthritis (OA).
- Trial name
- NCT05201040
- Testing
- JETKNEE Synovial Fluid Supplement, Normal saline
- Where
- 2 sites in Taiwan
- Volunteers
- 132 people
- Sponsor
- SciVision Biotech Inc.
Knee Osteoarthritis, Knee Pain Chronic
Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA
It is hypothesized that a single Intra-articular Injection of TTAX03, 100mg in 2mL of saline, will have more benefit with respect to the proportion of responders 12 weeks post-injection than an equal volume of saline, based on…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT05079035
- Testing
- TTAX03, Saline
- Where
- 10 sites in United States
- Volunteers
- 90 people
- Sponsor
- BioTissue Holdings, Inc
Knee Osteoarthritis
The Comparison of Knee Osteoarthritis Treatment With Bone Marrow Aspirate Concentrate , Leukocyte Rich Platelet Rich Plasma and Hyaluronic Acid
The aim of this study is to compare therapeutic and clinical effects of intra-articular injection of Bone Marrow Aspirate Concentrate (BMAC), inta-articular injection of Leukocyte Rich Platelet Rich plasma (LR-PRP) and 3 weekly…
- Trial name
- NCT03825133
- Testing
- Bone Marrow Aspirate Concentrate, Leukocyte Rich Platelet Rich Plasma, Hyaluronic Acid
- Where
- Serbia
- Volunteers
- 180 people
- Sponsor
- Clinical Center of Vojvodina
Osteoarthritis
The Clinical Effect of Pregabalin on Neuropathic Pain in Central Sensitized Patients After Total Knee Arthroplasty
In this study, patients scheduled to undergo total knee arthroplasty (TKA) will be screened through a survey for patients with central sensitivity and patients with neuropathic pain as preoperative evaluation.
- Trial name
- NCT05254652
- Testing
- Duloxetine 30mg, Pregabalin 150mg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- The Catholic University of Korea
Osteoarthritis of the Knee
Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee
The purpose of this study is to investigate the benefits of daily consumption of a high rosmarinic acid spearmint tea, developed by the University of Guelph, on measures of pain, physical function and disease activity in…
- Trial name
- NCT01380015
- Testing
- Commercially spearmint tea, High Rosmarinic Acid Spearmint Tea
- Where
- 2 sites in Canada
- Volunteers
- 49 people
- Sponsor
- University of Guelph
Knee Osteoarthritis, Knee Pain Chronic
Cognition, Pain and Wellbeing
Osteoarthritis (OA) is the most common form of arthritis and for 4 in 10 people pain from OA is not adequately controlled. The pain experience of people suffering from chronic pain largely depends on their individual perception…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- CPW (NCT04620525)
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Knee Injuries, Knee Arthritis
Kinematic Parameters to Predict Knee Diseases.
There is no study to explore the prediction of knee diseases using kinematic parameters of knee during gait. The aim of this study is to explore the possibility of predicting knee diseases by gait parameters.
- Trial name
- NCT03130400
- Testing
- Observational gait analysis procedure
- Where
- China
- Volunteers
- 1,914 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Knee Osteoarthritis, Knee Pain Chronic
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stimulation (NMES) for reducing pain and…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NMES (NCT03980964)
- Testing
- Active NMES
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Osteoarthritis of the Knee
Structured Non-operative Treatment of Knee Osteoarthritis
The purpose of this study is to test whether an algorithm for systematic non-surgical treatment consisting of corrective insoles, neuromuscular training, weight loss, patient education and pharmacological treatment with…
- Trial name
- NCT01535001
- Testing
- Neuromuscular training (NEMEX-TJR), Information, Paracetamol
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Osteoarthritis, Knee
Determination of the Effectiveness of Certain Physical Methods in the Treatment of Knee Osteoarthritis
Osteoarthritis (OA) is a chronic joint disease that involves the entire joint, causing cartilage damage, bone remodeling, osteophyte formation and loss of normal joint function.
- Trial name
- BFBOA (NCT04197284)
- Testing
- Biofeedback, Myomed 632, device for electrical stimulation, BTL 4000 Smart, kinesitherapy
- Where
- Croatia
- Volunteers
- 93 people
- Sponsor
- Clinical Hospital Centre Zagreb
Osteo Arthritis Knee
Effect of Combined Interventions on Pressure Pain Threshold
The effect of mobilizations on decrease of peripheral and central sensitivity has been proven in KOA. Furthermore, the effect of conservative therapy has also been proven in the increase of pain threshold in KOA.
- Trial name
- NCT04312035
- Testing
- end-range mobilization, Non end-range mobilization, Control
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- University of Pecs
Osteoarthritis, Knee
Retrospective Study of the Results of Cooled Radiofrequency for Genicular Nerves Neurotomy in 40 Consecutive Patients With Osteoarthritis of the Knee and Painful Knee Arthroplasty
Analyze the results of cooled radiofrequency in patients with chronic knee pain after one year of follow- up.
- Trial name
- NCT03343808
- Testing
- cooled radiofrequency ablation of genicular nerves
- Volunteers
- 40 people
- Sponsor
- Hospital Son Espases
Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD)
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins.
- Conditions
- Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD), Benign Prostatic Hyperplasia (BPH), Cholecystitis
- Trial name
- NCT06772558
- Testing
- Desflurane Inhalation, mechanical ventilation (MV)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Knee Arthritis Osteoarthritis
Different Hold Durations in Isometric Exercises
this stuy tries to evaulate the best contraction (hold time) during isometric effort that can provide the best therapeutic effects on muscular performance in patients with knee osteoarthritis
- Trial name
- NCT07198204
- Testing
- isometric exercises, therapeutic ultrasound, Transcutanous electrical nerve stimulation
- Where
- Egypt
- Volunteers
- 127 people
- Sponsor
- University of Hail
Osteoarthritis; Knee
IDEA-033 Three Months Dose Finding in OA Followed by IDEA-033 Three Months Extension in OA
The study objective is the eluciation of the dose-response function in efficacy (and possibly safety) in order to determine an optimal dose with respect to efficacy and safety.
- Trial name
- NCT00316784
- Testing
- IDEA-033 (and rescue medication)
- Volunteers
- 704 people
- Sponsor
- IDEA AG
Knee Osteoarthritis
Educational Program Associated With a Conventional Spa Therapy of Knee Osteoarthritis Patients
The main objective of this work is to measure the efficiency of 18 days SPA Therapy in orientation rheumatology associated with an educational intervention in patients with knee osteoarthritis on a priority objective…
- Trial name
- GETT2 (NCT03550547)
- Testing
- Educational workshops, Spa Therapy
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Association Francaise pour la Recherche Thermale
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