Clinical trials: Arthritis of the Knee
Osteoarthritis, Knee
Effects of Electrical Stimulation on Osteoarthritis of the Knee
The purpose of this study is to find out whether electrical stimulation can reduce knee pain and increase function in people with osteoarthritis of the knee.
- Trial name
- NCT00601497
- Testing
- InterX 5000
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Virginia
Osteoarthritis, Knee, Osteoarthritis, Hip
Helping Osteoarthritis Patients to Walk With NSAID
There is a lack of effective analgesic treatments to help walking patients with painful hip/knee osteoarthritis. Our team therefore imagined a new strategy lying on a multimodal rehabilitation walking program with the help of a…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain
- Trial name
- PERIPATEI (NCT05761015)
- Testing
- therapeutic program including intermittent drug intake and multimodal rehabilitation program
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis, Knee
Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Background: Progressive strength training is a training modality used in rehabilitation after total knee arthroplasty (TKA). Strength deficits up to 80% in the quadriceps muscle is shown to be present in the operated leg after…
- Trial name
- NCT01713140
- Testing
- 1 strength training set performed until contraction failure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Osteoarthritis of the Knee
Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to provide replicated evidence of safety and efficacy of 100 mg ketoprofen in Diractin®.
- Trial name
- NCT00722852
- Testing
- ketoprofen in Diractin®
- Where
- 37 sites in United States
- Volunteers
- 555 people
- Sponsor
- IDEA AG
Osteoarthritis of the Knee
Evaluation of Amniotic Fluid Product in Knee Osteoarthritis
A study evaluating Amniotic Fluid compared to a Saline Placebo Injection in the treatment of subjects with osteoarthritic (OA) knee pain
- Trial name
- NCT02768155
- Testing
- Amniotic Fluid 4.0ml dose, Amniotic Fluid 2.0ml dose
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- MiMedx Group, Inc.
Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease
PMCF Study on the Safety, Performance and Clinical Benefits Data of the NexGen TM Augmentation Patella
The study is a single-center, retrospective and prospective, non-randomized, non-controlled and consecutive series post-market study.
- Conditions
- Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease, Functional Deformity, Revision Total Knee Arthroplasty
- Trial name
- NCT05253976
- Where
- Switzerland
- Sponsor
- Zimmer Biomet
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Knee Osteoarthritis
Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study
The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al.
- Trial name
- NCT05202847
- Testing
- pulsed radiofrequency ablation to modifined points group, pulsed radiofrequency ablation to conventional points group
- Sponsor
- Gangnam Severance Hospital
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Knee Osteoarthritis
Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis
In recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to…
- Trial name
- NCT06463847
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Arthritis of the Knee Joint
Should my New Knee Rotate?
Total Knee Arthroplasty (TKA) is the surgical reconstruction of the knee joint in order to relieve pain, restore function and correct deformity.
- Trial name
- NCT02892838
- Testing
- mobile bearing knee system for total knee arthroplasty, fixed bearing total knee prosthesis
- Volunteers
- 106 people
- Sponsor
- Maastricht University Medical Center
Osteoarthritis, Knee
Influence of Osteoarthritis Information on Treatment Beliefs
The aim of this study is to evaluate the effect of educational information, with and without a general practitioner recommendation to exercise, on willingness to undertake exercise/physical activity for knee osteoarthritis.
- Trial name
- NCT04698655
- Testing
- Information on treatment options, Recommendation from general practitioner, Information on osteoarthritis
- Where
- Australia
- Volunteers
- 735 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Osteoarthritis, Knee
Simple Home-Based Exercise for Knee Osteoarthritis
1. Simple home-based standing balance training and isometric knee extension exercise for 4 weeks would improve functional ability and knee muscle strength of patients with knee osteoarthritis. 2.
- Trial name
- NCT00687726
- Testing
- Standing balance exercise, Isometric knee extension exercise
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Srinakharinwirot University
Knee Osteoarthritis, Osteoarthritis
Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease of the Knee
- Trial name
- HYDRO-KNEE (NCT07193368)
- Testing
- Polyacrylamide hydrogel 2.5% intra-articular injection
- Where
- Turkey (Türkiye)
- Volunteers
- 387 people
- Sponsor
- Feza Korkusuz MD
Knee Osteoarthritis
Effects of Gait Retraining on Lower Extremity Biomechanics
The purpose of this proposed study is to investigate both the acute and chronic response of frontal plane knee moment after gait retraining and to assess the effects on the biomechanics of the contralateral side.
- Trial name
- NCT03663790
- Testing
- Foot Progression, Trunk Lean
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- George Mason University
Osteoarthritis, Knee
An Effectiveness and Safety Study of IDEA-033 in Comparison to Oral Naproxen and Placebo for the Treatment of Osteoarthritis of the Knee
The purpose of this study is to identify the dose(s) of IDEA-033 that will provide a meaningful effect for treating osteoarthritis of the knee.
- Trial name
- NCT00211549
- Testing
- IDEA-033
- Where
- 100 sites in United States
- Volunteers
- 875 people
- Sponsor
- IDEA AG
Knee Osteoarthritis
Porous Baseplate in Total Knee Replacement
This is a multi-centre single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Advance Porous fixed bearing tibial baseplate and compatible femoral, patellar, and bearing components.
- Trial name
- NCT05226689
- Testing
- POROUS TIBIA BASEPLATE W/ JRNY LOCK
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
Knee Osteoarthritis, Persistent Postsurgical Pain
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
Chronic knee pain remains a disabling disease despite current treatment strategies. There is an increase in the prevalence of osteoarthritis (OA) of the knee in the general population, presently affecting approximately 450,000…
- Conditions
- Knee Osteoarthritis, Persistent Postsurgical Pain, Chronic Knee Pain
- Trial name
- COGENIUS (NCT05407610)
- Testing
- Conventional Radiofrequency ablation of the genicular nerves, Cooled Radiofrequency ablation of the genicular nerves
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Oost-Limburg
Knee Osteoarthritis
ESCAPE-pain Programme in Malaysia
The overall aim of this study is to develop an evidence based exercise programme for the management of knee osteoarthritis which is feasible and acceptable to patients and healthcare professionals in Malaysia.
- Trial name
- NCT03379623
- Testing
- ESCAPE-pain Programme
- Where
- 2 sites in Malaysia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Muhammad Kamil Che Hasan